A5027986135- Cardiac Arrhythmias and Treatments
- Cancer-related molecular mechanisms research
- Atrial Fibrillation Management and Outcomes
- Cardiac electrophysiology and arrhythmias
- MicroRNA in disease regulation
- Cardiac pacing and defibrillation studies
- Cardiac Arrest and Resuscitation
- Adipose Tissue and Metabolism
- Pulmonary Hypertension Research and Treatments
- Congenital Heart Disease Studies
- Anesthesia and Neurotoxicity Research
- Blood Pressure and Hypertension Studies
- Tracheal and airway disorders
- Heart Rate Variability and Autonomic Control
- Cardiac Ischemia and Reperfusion
- Cardiomyopathy and Myosin Studies
- Cardiac Imaging and Diagnostics
- Viral Infections and Immunology Research
- Cardiovascular Syncope and Autonomic Disorders
- Lipid metabolism and disorders
- Thermal Regulation in Medicine
- Congenital Diaphragmatic Hernia Studies
- Kruppel-like factors research
- Venous Thromboembolism Diagnosis and Management
- Cholesterol and Lipid Metabolism
Loma Linda University Medical Center
2024
Orange Coast Memorial Medical Center
2024
Loma Linda University
2024
New York University
2011-2016
SUNY Downstate Health Sciences University
2011-2016
State University of New York
2011-2016
Cellular imbalances of cholesterol and fatty acid metabolism result in pathological processes, including atherosclerosis metabolic syndrome. Recent work from our group others has shown that the intronic microRNAs hsa-miR-33a hsa-miR-33b are located within sterol regulatory element-binding protein-2 -1 genes, respectively, regulate homeostasis concert with their host genes. Here, we show miR-33a -b also genes involved insulin signaling. target key enzymes regulation oxidation, carnitine O...
Objective— The ATP-binding cassette transporter A1 (ABCA1) is a major regulator of macrophage cholesterol efflux and protects cells from excess intracellular accumulation; however, the mechanism involved in posttranscriptional regulation ABCA1 poorly understood. We previously showed that microRNA-33 (miR-33) 1 regulator. Here, we investigated potential contribution other microRNAs (miRNAs) to efflux. Methods Results— performed bioinformatic analysis for identifying miRNA target prediction...
Lipid accumulation in macrophages has profound effects on macrophage gene expression and contributes to the development of atherosclerosis. Here, we report that angiopoietin-like protein 4 (ANGPTL4) is most highly upregulated foamy it's absence haematopoietic cells results larger atherosclerotic plaques, characterized by bigger necrotic core areas increased apoptosis. Furthermore, hyperlipidemic mice deficient ANGPTL4 have higher blood leukocyte counts, which associated with an increase...
<b><i>Background:</i></b> Head-up tilt table testing (HUTT) is time-consuming and associated with increased patient morbidity. Hemodynamic changes that occur during the early phase of HUTT may be predictive neurocardiogenic syncope. <b><i>Methods:</i></b> A retrospective chart review was performed in 119 consecutive African Americans ( 57 ± 19) who underwent for evaluation syncope unknown etiology. Positive responses were defined as development...
Background: Right ventricular (RV) dysfunction has been associated with adverse clinical outcomes in patients heart failure (HF). Cardiac resynchronization therapy (CRT) improves left (LV) size and function markedly abnormal ECG QRS duration. However, relationship of baseline RV response to CRT not well described. Objective: To investigate the as assessed by change LV ejection fraction (LVEF). Methods: A systematic search studies published between 1966 February 2015 was conducted using Pub...