A5038587156- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Cardiac pacing and defibrillation studies
- Cardiac electrophysiology and arrhythmias
- Venous Thromboembolism Diagnosis and Management
- RNA modifications and cancer
- Cardiovascular Syncope and Autonomic Disorders
- COVID-19 Clinical Research Studies
- Cardiac Structural Anomalies and Repair
- Neurological disorders and treatments
- Non-Invasive Vital Sign Monitoring
- SARS-CoV-2 and COVID-19 Research
- Pericarditis and Cardiac Tamponade
- Esophageal and GI Pathology
- Gastroesophageal reflux and treatments
- Cardiac Arrest and Resuscitation
- Long-Term Effects of COVID-19
- Health Systems, Economic Evaluations, Quality of Life
- Vascular anomalies and interventions
- Esophageal Cancer Research and Treatment
- Hemodynamic Monitoring and Therapy
- Central Venous Catheters and Hemodialysis
- Cancer Mechanisms and Therapy
- ECG Monitoring and Analysis
- Cardiac Imaging and Diagnostics
Toronto Metropolitan University
2025
St George’s University Hospitals NHS Foundation Trust
2017-2024
St George's Hospital
2020-2024
Guy's and St Thomas' NHS Foundation Trust
2024
The University of Texas Southwestern Medical Center
2024
Cardiovascular Research Associates
2024
St George's Hospital
2018-2023
St George's, University of London
2017-2021
Royal Surrey County Hospital
2021
Université Paris-Saclay
2021
Thermal injury to the oesophagus is an important cause of life-threatening complication after ablation for atrial fibrillation (AF). protection oesophageal lumen by infusing cold liquid reduces thermal a limited extent. We tested ability more powerful method temperature control reduce incidence injury.A single-centre, prospective, double-blinded randomized trial was used investigate ensoETM device protect from injury. This compared in 1:1 randomization with group standard practice utilizing...
The Coherent Hemodynamic Spectroscopy (CHS) model provides a quantitative framework for modeling cerebral hemodynamics and metabolism, particularly in response to small physiological perturbations. However, its original approximate formulation it was limited conditions where parameter changes were constrained 10–20%, making unsuitable extreme disruptions such as cardiac arrest. In this study, we present detailed discussion of the algorithm using complete CHS model, which extends by solving...
The Coherent Hemodynamic Spectroscopy (CHS) model provides a quantitative framework for modeling cerebral hemodynamics and metabolism, particularly in response to small physiological perturbations. However, its original approximate formulation it was limited conditions where parameter changes were constrained 10–20%, making unsuitable extreme disruptions such as cardiac arrest. In this study, we present detailed discussion of the algorithm using complete CHS model, which extends by solving...
Abstract Introduction Research evidence has shown that catheter ablation is a safe and superior treatment for atrial fibrillation (AF) compared to medical therapy, but real‐world practice been slow adopt an early interventional approach. This study aims determine the cost effectiveness of therapy from perspective United Kingdom. Methods A patient‐level Markov health‐state transition model was used conduct cost‐utility analysis. The population included patients previously treated AF with...
Abstract Introduction The IMPACT study established the role of controlled esophageal cooling in preventing thermal injury during radiofrequency (RF) ablation for atrial fibrillation (AF). effect on lesion delivery and procedural patient outcomes had not been previously studied. objective was to determine formation RF lesions, ability achieve endpoints, clinical outcomes. Methods Participants trial underwent AF guided by Ablation Index (30 W at 350–400 AI posteriorly, 40 ≥450 anteriorly). A...
Abstract Aims Transvenous lead extraction (TLE) is important in the management of cardiac implantable electronic devices but carries risk. It most commonly completed from superior access, often with ‘bail-out’ support via femoral approach. Superior and inferior access may be used tandem, which has been proposed as an advance safety efficacy. The aim this study to evaluate efficacy Tandem Method ‘Tandem’ procedure entailed grasping targeted right atrium provide countertraction a rotational...
Readmissions are common following acute exacerbations of chronic obstructive pulmonary disease (AECOPD) and partially responsible for increased morbidity mortality in COPD. Numerous factors have been shown to predict readmission patients previously admitted hospital AECOPD; however, related who triaged emergency departments (EDs) sent directly home poorly understood. We postulate that seen the ED AECOPD a high rate, we suspect inadequate management follow-up contribute this rate.We conducted...
To chart the effect of COVID-19 pandemic on activity interventional electrophysiology services in affected regions.We reviewed laboratory records three cities: Wenzhou China, Milan Italy, and London UK. We inspected catheter lab interviewed electrophysiologists each centre to gather information impact working patterns health staff members patients. There was a striking decline centres. The occurred within week recognition widespread community transmission virus region shows correlation with...
Abstract Background Esophageal thermal injury can occur after radiofrequency (RF) ablation in the left atrium to treat atrial fibrillation. Existing methods prevent esophageal have various limitations deployment and uncertainty efficacy. A new heat transfer device currently available for whole-body cooling or warming may offer an additional option injury. We sought develop a mathematical model of this process guide further studies clinical investigations compare results real-world data....
Protamine sulfate is commonly used to reverse the action of heparin after catheter ablation procedures. Serious protamine-related adverse effect rare, but its recognition and appropriate management by electrophysiologists intensivists important. Direct ventricular fibrillation (VF) soon a slow infusion protamine has not been clearly described. We examined records all patients who suffered apparent events administration in our electrophysiology lab from 2013 2018. describe series three...
The Sars-Cov-2 infection is a multisystem illness that can affect the cardiovascular system. Tachyarrhythmias have been reported but prevalence of bradyarrhythmia unclear. Cases described transient high-degree atrioventricular (AV) block in COVID-19 were managed conservatively.A database all patients requiring temporary or permanent pacing two linked cardiac centers was used to compare number procedures required during first year pandemic compared corresponding period earlier....
Abstract Aims Restoring sinus rhythm (SR) by ablation alone is an endpoint used in radiofrequency (RF) for long-standing persistent atrial fibrillation (AF) but not with cryotherapy. The simultaneous use of two cryotherapy catheters can improve efficiency; we compared this RF chronic AF aiming termination to SR alone. Methods and results Consecutive patients undergoing their first >6 months duration were screened. A total 100 participants randomized 1:1 multi-catheter or RF. For...
A patient with shocks from his ICD related to AF underwent redo ablation. The only identifiable target was the superior vena cava. This isolated using ultra-low cryotherapy, eliminating episodes of AF. 53-year-old man non-ischemic dilated cardiomyopathy (ejection fraction 35%), received recurrent dual-chamber implantable cardioverter-defibrillator (ICD) because atrial fibrillation (AF), 7 years after an extensive radiofrequency ablation including pulmonary veins (PVs) isolation, left roof,...
Atrial fibrillation, the most prevalent cardiac arrhythmia, is treated by catheter ablation to isolate electrical triggers. Clinical trials on robotic systems hold promise for improving safety and efficacy of procedure. However, expense proprietary designs hinder accessibility such systems. This paper details an open-source, modular, three-degree-of-freedom platform teleoperating commercial catheters through joystick navigation. We also demonstrate a catheter-agnostic handle interface...
Abstract Background Proactive esophageal cooling is increasingly being utilized, and now FDA cleared, to reduce the likelihood of ablation-related injury resulting from radiofrequency (RF) cardiac ablation atrial fibrillation (AF). One-year follow-up largest randomized controlled study, IMPACT trial, showed a trend towards improvement in long-term efficacy versus luminal temperature (LET) monitoring. With larger data sets available for analysis, we sought determine 1-year freedom arrhythmia...