A5089157487- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Cardiac pacing and defibrillation studies
- Cardiac electrophysiology and arrhythmias
- Cardiac Valve Diseases and Treatments
- Cardiac Imaging and Diagnostics
- Cardiomyopathy and Myosin Studies
- Venous Thromboembolism Diagnosis and Management
- Cardiovascular Syncope and Autonomic Disorders
- Healthcare Technology and Patient Monitoring
- Cardiac Structural Anomalies and Repair
- Pericarditis and Cardiac Tamponade
- Health Systems, Economic Evaluations, Quality of Life
- Respiratory Support and Mechanisms
- Infective Endocarditis Diagnosis and Management
- Quality and Safety in Healthcare
- Cardiovascular Function and Risk Factors
- Mechanical Circulatory Support Devices
- Cardiac Arrest and Resuscitation
- Sarcoidosis and Beryllium Toxicity Research
- Trauma Management and Diagnosis
- Aerodynamics and Fluid Dynamics Research
- Thermal Regulation in Medicine
- Tissue Engineering and Regenerative Medicine
- Mitochondrial Function and Pathology
NorthShore University HealthSystem
2016-2025
University of Chicago Medical Center
2025
University of Chicago
2011-2024
Evanston Hospital
2020-2024
North Shore University Hospital
2024
Endeavor Charter School
2024
Swedish Covenant Hospital
2024
Clinical Research Solutions
2024
University of Illinois Chicago
2024
The University of Texas Southwestern Medical Center
2022-2023
Active esophageal cooling reduces the incidence of endoscopically identified severe lesions during radiofrequency (RF) catheter ablation left atrium for treatment atrial fibrillation. A formal analysis atrioesophageal fistula (AEF) rate with active has not previously been performed.
Abstract Background Active esophageal cooling during pulmonary vein isolation (PVI) with radiofrequency (RF) ablation for the treatment of atrial fibrillation (AF) is increasingly being utilized to reduce injury and atrioesophageal fistula formation. Randomized controlled data also show trends towards increased freedom from AF when using active cooling. This study aimed compare 1-year arrhythmia recurrence rates between patients treated luminal temperature (LET) monitoring versus left...
Inactivation of the transcription factor p53 is central to carcinogenesis. Yet only approximately one-half cancers have loss-of-function mutations. Here, we demonstrate a mechanism for inactivation by apoptosis repressor with caspase recruitment domain (ARC), protein induced in multiple cancer cells. The direct binding nucleus ARC tetramerization inhibits tetramerization. This exposes nuclear export signal p53, triggering Crm1-dependent relocation cytoplasm. Knockdown endogenous breast cells...
During atrial fibrillation ablation (AFA), achievement of first pass isolation (FPI) reflects effective lesion formation and predicts long-term freedom from arrhythmia recurrence. We aim to determine the clinical procedural predictors pulmonary vein FPI.
Radiofrequency (RF) ablation to perform pulmonary vein isolation (PVI) for the treatment of atrial fibrillation involves some risk collateral structures, including esophagus. Proactive esophageal cooling using a dedicated device has been granted marketing authorization by Food and Drug Administration (FDA) reduce ablation-related injury due RF cardiac procedures, more recent data also suggest that may contribute improved long-term efficacy treatment. A mechanistic underpinning explaining...
ABSTRACT Severe tricuspid regurgitation (TR) is associated with significant morbidity and mortality. Management of severe TR includes treatment the underlying cause(s), medical therapy less commonly surgical valve repair. Newer transcatheter repair devices show promise for those patients who remain symptomatic despite such efforts. The presence a Cardiac Implantable Electronic Device (CIED) leads across poses challenge from both diagnostic therapeutic standpoints. In this paper, we propose...
For evaluation of the pulmonary arteries in patients suspected embolism, CT angiography (CTA) is first-line imaging test with contrast-enhanced MR (CEMRA) a potential alternative. Disadvantages CTA include exposure to ionizing radiation and an iodinated contrast agent, while CEMRA sensitive respiratory motion requires gadolinium-based agent. The primary goal our technical feasibility study was evaluate arterial conspicuity using breath-hold free-breathing implementations recently-developed...
Active esophageal cooling is increasingly utilized as an alternative to luminal temperature (LET) monitoring for protection against thermal injury during pulmonary vein isolation (PVI) when treating atrial fibrillation (AF). Published data demonstrate the efficacy of active in reducing injury, but impacts on procedural efficiency are not well characterized. LET compels pauses ablation due heat stacking and overheating alarms that turn delay progress PVI procedure, whereas allows avoidance...