A5060518779- Natural Compound Pharmacology Studies
- Insect Pest Control Strategies
- Insect and Pesticide Research
- Vector-borne infectious diseases
- Phytochemistry and biological activity of medicinal plants
- Multiple Myeloma Research and Treatments
- Biological Activity of Diterpenoids and Biflavonoids
- Synthesis of Organic Compounds
- Beetle Biology and Toxicology Studies
- Phytochemical compounds biological activities
- Essential Oils and Antimicrobial Activity
- Phytochemicals and Medicinal Plants
- Pesticide Exposure and Toxicity
- Psidium guajava Extracts and Applications
- Genomics, phytochemicals, and oxidative stress
- Natural product bioactivities and synthesis
- Traditional Chinese Medicine Analysis
- Reproductive Biology and Fertility
- Cancer therapeutics and mechanisms
- Drug-Induced Hepatotoxicity and Protection
- Immunotoxicology and immune responses
- Poisoning and overdose treatments
- Systemic Lupus Erythematosus Research
- Paraquat toxicity studies and treatments
- Phytochemistry and Biological Activities
University of Illinois Chicago
2018-2023
Guru Angad Dev Veterinary and Animal Sciences University
2013-2017
Tamil Nadu Veterinary and Animal Sciences University
2015
Rosemary extract (RE) is an approved food preservative in the European Union and contains dietary phytochemicals that are beneficial for gastrointestinal health. This study investigated effects of RE on dextran sodium sulfate (DSS)-induced colitis also determined pharmacokinetics administered to mice via oral gavage. Individual components rosemary were separated identified by LC–MS/MS. The two major diterpenes from RE, carnosic acid (CA) carnosol (CL), gavage determined. Then, effect...
The mangosteen fruit is a popular Southeast Asian consumed for centuries. There have been variety of xanthones isolated from the fruit, bark, roots and leaves with each having unique chemical physical properties. Previously, most abundant xanthone α-mangostin has shown to inhibit CDK4. Herein we describe role selected inhibiting evidence provide here that key functional groups are required CDK4 protein prevent phosphorylation downstream targets critical uncontrolled cell cycle progression....
Rosemary is abundant with phytochemicals and has recently been approved as an antioxidant food preservative in the European Union. The safety of rosemary well established, however, benefits on gastrointestinal health are less known. Our overall hypothesis that including carnosol have potential to promote by activation sestrin-2 when consumed our diet.Colon cells HCT116 SW480 were treated evaluated MTT, immunofluorescence, ELISA, Western blot analysis understand modulation PERK/Nrf2/Sestrin-2...
A major limitation of current prostate cancer pharmacotherapy approaches is the inability these compounds to target androgen receptor variants or mutants that develop during progression. The demand for novel therapeutics prevent, slow, and treat significant because FDA approved anti-androgens are associated with adverse events can eventually drive drug-resistant cancer. This study evaluated α-mangostin its ability degrade variants. α-Mangostin one more than 70 isoprenylated xanthones...
Background: Emu oil is a product of animal origin used for the treatment inflammation, burns etc. as part aboriginal medicine in Australia.Crohn's disease common inflammatory manifestation humans and other species relating to ulceration digestive disturbances upper gastro-intestinal tract.Aloe vera commonly substance from plant sources wound healing various properties.Given difference source substances all while playing similar therapeutic role different parts world, present investigation...
Uncontrolled regulation of cyclin dependent kinases (CDKs) has negative implications in many cancers and malignancies recently led to the approval select CDK inhibitors. Herein we present data reporting that xanthones, a class compounds isolated from purple mangosteen (Garcinia mangostana) fruit, can inhibit CDK2/CyclinE1. We evaluated nine different including α-mangostin, β-mangostin, γ-mangostin, gartanin, 8-desoxygartanin, garcinone C, D, 9-hydroxycalabaxanthone, 3-isomangostin for...
High dose melphalan (HDM) and autologous stem cell transplant (ASCT) is standard of care for multiple myeloma (MM), but there significant variability in exposure (area under the plasma drug concentration-time curve, AUC) when using body surface area-based dosing. Our aim was to establish a method pharmacokinetic (PK) testing real-time adjustments.
Abstract The present study was planned with an objective to test the pharmacokinetics of a new formulation enrofloxacin (Flobac ® SA ) in buffalo calves. drug administered at dose rate 7.5 mg kg −1 body weight through intravenous (i.v.) and intramuscular (i.m.) route followed by plasma collection analysis different time intervals. After analysis, using High Performance Liquid Chromatography – Ultraviolet, various pharmacokinetic parameters were calculated visual fit for compartmental...
Pesticide poisoning is a common occurrence around the world. Pesticides can act on various body systems resulting in toxicity. Flubendiamide new generation pesticide, reported to have better activity against Lepidopteran insects. The present study was carried out with an objective analyze effects of flubendiamide sub-acute exposure hematology rats.Male and female Sprague Dawley (SD) rats (9-11 weeks) were divided into five groups six animals each group. First group served as control, while...
The purple mangosteen fruit (Garcinia mangostana), native to Southeast Asia, has long been used in traditional medicine, however recent data shown that xanthones, a class of chemical compounds isolated from the mangosteen, display anti-cancer activity [1]. α-Mangostin is most abundant xanthone with more than 80 have and identified fruit, roots, bark, leaves mangosteen. Androgen receptor (AR) degradation novel strategy would help overcome rising drug resistance FDA approved anti-androgens are...
The present study was carried out to evaluate the aldrin-induced oxidative stress and apoptosis in murine macrophage (J774A.1) cells. Acute exposure of aldrin for 2 hrs given J774A.1 cells cultured DMEM with 10% FBS at 37oC 5% CO2 air 95% relative humidity under vitro system. Lethal concentration-50 (LC50) calculated after period as 7.24 μg/ml. Further, were exposed three different concentration (1.81, 3.65 μg/ml) 0.1% DMSO used negative control. antioxidant enzymes non-enzymes determined...
The fruit of Emblica officinalis (commonly known Amla) contain potent antioxidants and is most commonly used in the Ayurveda for treatment various diseases. Quinalphos- a organophorus insecticide to alter antioxidant defense system mammals. With this premise, experiment was planned with objective study effect amla extract supplementation on quinalphos induced oxidative stress. Twenty-four Sprague-Dawley rats were homogenously divided into six groups four animals each. Group I kept as...
High dose melphalan (HDM) and autologous stem cell transplantation (ASCT) is standard of care for multiple myeloma (MM). However, ∼40% patients fail to achieve complete remission, in part due variability exposure (AUC) when using body-surface-area (BSA)-based dosing, which results suboptimal response. HDM, 100mg/m2 on day -2 -1, allows potential -1 modification if pharmacokinetic (PK) testing with rapid turnaround performed. Here we describe a clinically reproducible method PK that real-time...