A simple and efficient Cu-catalyzed decarboxylative/click reaction for the preparation of 1,4-disubstituted 5-arylselanyl-1,2,3-triazoles from propiolic acids, diselenides, azides has been developed. The mechanistic study revealed that intermolecular AAC an alkynyl selenium intermediate occurred. resulting multisubstituted 5-seleno-1,2,3-triazoles were tested in vitro anticancer activity by MTT assay, compounds 4f, 4h, 4p showed potent cancer cell-growth inhibition activities.

The functionalised RhB-EtOH-I dye was identified as an efficient and reusable organocatalyst for the conversion of CO 2 epoxides into cyclic carbonates under mild conditions.

Herein we report an effective and simple preparation method of substituted azoxybenzenes by reductive dimerization nitrosobenzenes. This procedure requires no additional catalyst/reagent can be applied to substrates with a wide range substitution patterns.

Abstract α,β‐Unsaturated carbonyl compounds are among the most fundamentally important functional and widely applied in synthetic chemistry, medical chemistry material chemistry. Thus, their synthesis has attracted much attention of chemists. The dehydrogenation two adjacent sp 3 C−H bonds can directly construct carbon‐carbon double with high atom efficiency, been used for preparing unsaturated as a powerful strategy. Herein, we highlight recent advances preparation valuable α,β‐unsaturated...

A series of novel dye-based organocatalysts was designed, synthesised and tested in the cycloaddition CO2 to styrene oxide yielding carbonate under mild reaction conditions (45 °C, 10 bar CO2). Tuning acid strength geometry -OH functional group modified dyes allowed generation a tailored bifunctional catalyst (RhB-Ethyl-PhOH-I) with enhanced catalytic activity.

Abstract A general and convenient palladium‐catalyzed oxidative Heck arylation of both N ‐protected , ‐diprotected allylic amines with arylboronic acids under mild conditions has been developed. The catalyst system, consisting Pd(OAc) 2 (palladium acetate), AgOAc (silver acetate) KHF (potassium hydrogen fluoride), could efficiently catalyze the coupling reaction in acetone without aid any ligand, leading exclusively to γ‐arylated amine products good excellent yields. This method is...

Abstract A highly efficient copper‐catalyzed protocol for the synthesis of bis‐ and tris‐selenide alkenes from alkynyl carboxylic acids diselenides has been developed. The reaction in presence CuI/Cs 2 CO 3 /toluene under white light LEDs only gave bis‐selenide alkenes, whereas were obtained a /NMP system. This method provides rapid access to derivatives.

Abstract An efficient and selective approach to the synthesis of selenide ethers containing one or two geminal C–Se bonds from readily available diselenides phenylacetic acids was developed. Compounds bond were prepared by employing air as oxidant under metal‐free conditions, whereas compounds having formed via iron(III) chloride/oxygen/cesium carbonate (FeCl 3 /O 2 /Cs CO ) system. Moreover, 1,2‐diphenyldisulfane also could be smoothly converted into corresponding sulfur ether product...

Electrophilic cyclization reactions are one of the most useful strategies for construction various cyclic compounds and significant progress has been made in electrophilic cyclizations triggered by diaryliodonium salts.In these new types reactions, salts can not only act as arylation reagents to initiate arylation-cyclization giving aryl-substituted compounds, but also be involved benzocyclization give benzocycles.

The first application of a RuHCl(CO)(PPh3)3-OAc catalytic system on the selective intermolecular mono C-H silylation 2-aryl N-heterocycles using HSiEt3 as silylating reagent has been described. This protocol features good functional group tolerance and high regioselectivity, potential for gram scale-up, which provides convenient practical pathway synthesis versatile organosilane compounds. can also be applied to challenging sp3 bonds.

Abstract Multifunctional 3‐amino‐4‐dialkylphosphono‐2‐quinolinones have been prepared by “one‐pot” nucleophilic addition and regioselective ring enlargement of imino isatins. The reaction between isatins dialkyl (diazomethyl)phosphonate proceeds smoothly using potassium carbonate as a catalyst, subsequent expansion promotes salicylic acid to afford the desired products in high yields. magnified image

The first total synthesis of asperphenins A and B has been accomplished in a concise, highly stereoselective fashion from commercially available materials (15 steps, 9.7% 14.2% overall yields, respectively). convergent route featured the judicious choice protecting groups, fragment assembly strategy late-stage iron-catalyzed Wacker-type selective oxidation an internal alkene to corresponding ketone.

Owing to the separation of field-effect transistor (FET) devices from sensing environments, extended-gate FET (EGFET) biosensor features high stability and low cost. Herein, a highly sensitive EGFET based on GaN micropillar array polycrystalline layer (GMP) was fabricated, which prepared by using simple one-step low-temperature MOCVD growth. In order improve sensitivity detection limit biosensor, surface area electrical conductivity electrode can be increased layer, respectively. The...

Silatranes are organosilicon compounds with outstanding biological activities.Eleven substituted benzoyl aminopropyl silatranes(a-k) have been synthesized by the reaction of silatrane various chlorides.IR, 'HNMR, MS and elemental analysis confirmed their structures.The antibacterial test showed that they were efficient against Fusarium Rhizataonia.

Abstract Methyl methoxyacetate (MMAc), a precursor to ethylene glycol (EG), was synthesized successfully via the liquid-phase carbonylation of dimethoxymethane (DMM) catalyzed by heteropolyacids (HPAs). The experiment results showed that H3PW12O40 (PW12) exhibited best catalytic performance for DMM, and its high activity attributed synergistic effect between superior acidic strength polarity solvent.

Compound Arnebiae radix oil has been clinically applied to treat burns and scalds for a long time. However, it is unstable inconvenient use. The aim of this study was prepare compound microemulsion gel transdermal delivery system evaluate its characteristics.Based on the solubility Shikonin, active component results phase studies, adequate ratio each in determined. optimized prepared using Carbomer 940. gels were characterized terms appearance, preliminary stability test content Shikonin...

Abstract In this article a palladium‐catalyzed Kumada reaction was reported. The procedure mild and tolerated series of aryl bromides, affording the biaryls in good to excellent yield.

Abstract A highly efficient and eco‐friendly esterification is achieved by a series of novel dicationic ionic liquids (the most shown in the scheme).

Abstract The title compounds are prepared by one‐pot nucleophilic addition and regioselective ring enlargement of imino isatins.