A5085382165- Synthesis and biological activity
- Multiple and Secondary Primary Cancers
- Lung Cancer Treatments and Mutations
- Natural Antidiabetic Agents Studies
- Lipid metabolism and biosynthesis
- Autophagy in Disease and Therapy
- Synthesis and Characterization of Heterocyclic Compounds
- Natural product bioactivities and synthesis
- Sirtuins and Resveratrol in Medicine
- Phytochemicals and Antioxidant Activities
- Synthesis and Biological Evaluation
- Quinazolinone synthesis and applications
- Ginseng Biological Effects and Applications
- Oral Health Pathology and Treatment
- Chemical Reactions and Isotopes
- Bioactive Compounds in Plants
- Bladder and Urothelial Cancer Treatments
- Synthesis and Reactivity of Heterocycles
- Essential Oils and Antimicrobial Activity
- Bioactive Compounds and Antitumor Agents
- NF-κB Signaling Pathways
- Synthesis of Organic Compounds
- Lung Cancer Diagnosis and Treatment
- Tannin, Tannase and Anticancer Activities
- Antioxidant Activity and Oxidative Stress
Harokopio University of Athens
2015-2024
University of West Attica
2021-2023
Evangelismos Hospital
2019
National and Kapodistrian University of Athens
2008
Levosimendan (LEVO) a clinically-used inodilator, exerts multifaceted cardioprotective effects. Case-studies indicate protection against doxorubicin (DXR)-induced cardiotoxicity, but this effect remains obscure. We investigated the and mechanism of different regimens levosimendan on sub-chronic chronic cardiotoxicity.Based preliminary in vivo experiments, rats serving as model doxorubicin-cardiotoxicity were divided into: Control (N/S-0.9%), DXR (18 mg/kg-cumulative), DXR+LEVO (LEVO, 24...
Beta-glucan rich mushrooms may exert beneficial<italic>in vitro</italic>effects on bone physiology by alterations in the gut microbiota and/or SCFAs.
Resveratrol, a naturally occurring stilbene, exhibits numerous beneficial health effects. Various studies have demonstrated its diverse biological actions, including anti-oxidant, anti-inflammatory, and anti-platelet properties, thereby supporting potential for cardio protection, neuroprotection, anti-cancer activity. However, significant limitation of resveratrol is weak bioavailability. To overcome this challenge, multiple research groups investigated the synthesis new derivatives to...
Prostate cancer is the second most commonly diagnosed in men worldwide, which almost incurable, once it progresses into metastatic stage. Adriamycin (ADR) a known chemotherapeutic agent that causes severe side effects. In recent years, studies natural plant products have revealed their anticancer activities. particular, Glycyrrhiza glabra enhanced extract (GGE), as licorice, has been reported to exert antiproliferative properties against cells. this study, cytotoxic potential of GGE was...
Silymarin-enriched extract (SEE) is obtained from Silybum marianum (Asteraceae). Doxorubicin (DXR) a widely used chemotherapeutical yet with severe side effects. The goal of the present study was to assess pharmacologic effect SEE and its bioactive components silibinin silychristine when administrated alone or in combination DXR human prostate cancer cells (PC-3). PC-3 were treated SEE, (silybins A B), silychristine, alone, DXR, cell proliferation assessed by MTT assay. Cell cycle,...
Purine analogues are important therapeutic tools due to their affinity enzymes or receptors that involved in critical biological processes. In this study, new 1,4,6-trisubstituted pyrazolo[3,4-b]pyridines were designed and synthesized, cytotoxic potential was been studied. The derivatives prepared through suitable arylhydrazines, upon successive conversion first aminopyrazoles, they converted then 1,6-disubstituted pyrazolo[3,4-b]pyridine-4-ones; served as the starting point for synthesis of...
Abstract Sixteen novel hydroxytyrosol (HT) analogs with substitutions at the C‐1 position of HT aliphatic side chain were synthesized and evaluated for their cytostatic activity against MG‐63 human osteoblast‐like cells antioxidant properties. The results revealed that these exhibited significantly higher inhibitory compared HT, which served as positive control. Among these, cyclo‐substituted compounds stood out particularly potent, demonstrating strong radical scavenging abilities notable...
The phenolic component Oleuropein (OLEU), a bioactive natural product, has recently shown antiproliferative properties. Doxorubicin (DXR) is an anthracycline present in many chemotherapeutic schemes, although limited due to its cardio-toxic effects. Important research effort been devoted therefore, reducing DXR toxicity without compromising antitumor efficacy. anticancer actions of and OLEU were assessed, on PC-3 prostate cancer cells, while cell cycle distribution rate apoptosis assessed by...
Pumpkin seed is a rich source of polyphenols and other bioactive compounds that may act as chemopreventive agents against cancer. In this study, five different extracts pumpkin seeds were evaluated for their ability to affect proliferation autophagy on PC-3 prostate cancer cells. All (water [W], methanolic, acetone, ethylacetate, polar lipid [PL]) inhibited cell in dose-dependent manner. Treatment cells with the PL extract increased distribution S phase, whereas W induced significantly....
Oleuropein (OLEU) is the most distinguished phenolic compound found in olive fruit and leaves of Olea europaea L., with several pharmacological properties, including anti-cancer actions. Adriamycin (ADR) an anthracycline widely used as a chemotherapeutic agent, although it presents significant side effects. The aim present study was to investigate effect oleuropein alone (20 μg/mL) co-treatment ADR (50 nM), MG-63 human osteosarcoma cells. Therefore, cellular molecular techniques, such MTT...
Purine isosteres are often endowed with interesting pharmacological properties, due to their involvement in cellular processes replacing the natural purines. Among these compounds, pyrazolopyridines under active investigation for potential anticancer properties.Based on previously discovered substituted promising antiproliferative activity, we designed and synthesized new, suitably analogues aiming investigate activity contribute SAR studies of this class bioactive compounds.The new...
Several pyrazolopyridines possess promising pharmacological activities, mainly attributed to their antagonistic nature towards the natural purines in many biological processes. Cytotoxicity and anticancer potential of this class compounds is related induction apoptotic cell death inhibition protein kinases.
Recent trends have shown a dramatic rise in the incidence of oropharyngeal squamous cell carcinoma strongly associated with high-risk human papillomavirus (HPV) type 16. The genetic variability HPV16 has been extensively studied cervical cancer but there are very limited published data concerning variations this HPV cancer. In present study, E6 gene sequences originated from small cohort Greek patients diagnosed were assessed. vast majority clustered within European variant branch. T350G...
Several new amino-substituted acridone and xanthone derivatives have been designed synthesized, using an efficient methodology from suitable acridone- or xanthone-carboxylic acid intermediates. The antiproliferative activity of the target compounds has evaluated against four cancer cell lines, namely breast adenocarcinoma MCF-7, acute lymphocytic leukemia CCRF-CEM, its doxorubicin-resistant variant CEM/ADR5000 prostate PC-3 lines. Selected also tested urinary bladder T24 metastatic melanoma...
A number of pyrrolo[2,3-c]pyridines, pyrrolo[3,2-d]pyrimidines and pyrazolo[4,3-d]pyrimidines were designed synthesized as antiproliferative agents. The target compounds possessed selected substituents in analogous positions on the central scaffold that allowed extraction interesting SARs. cytotoxic activity new derivatives was evaluated against prostatic (PC-3) colon (HCT116) cell lines, most potent analogues showed IC50 values nM to low µM range, while they found be non-toxic normal human...