A5039340051- Nerve injury and regeneration
- Endoplasmic Reticulum Stress and Disease
- Autophagy in Disease and Therapy
- Vestibular and auditory disorders
- Cell death mechanisms and regulation
- Sleep and Wakefulness Research
- Neurogenesis and neuroplasticity mechanisms
- Hedgehog Signaling Pathway Studies
- Hereditary Neurological Disorders
- Nuclear Structure and Function
- Genetics, Aging, and Longevity in Model Organisms
- Extracellular vesicles in disease
- CRISPR and Genetic Engineering
- Biochemical and biochemical processes
- Prion Diseases and Protein Misfolding
- Signaling Pathways in Disease
- Developmental Biology and Gene Regulation
- Trace Elements in Health
- Neuroscience of respiration and sleep
- Cellular transport and secretion
- Genetic Neurodegenerative Diseases
- PARP inhibition in cancer therapy
- Genomics and Chromatin Dynamics
- Parkinson's Disease Mechanisms and Treatments
- Epigenetics and DNA Methylation
Albert Einstein College of Medicine
2022-2024
Center for Climate and Resilience Research
2016-2021
Pontificia Universidad Católica de Chile
2015-2020
Universidad Mayor
2016-2020
University of Chile
2011-2016
Millennium Science Initiative
2016
Buck Institute for Research on Aging
2016
Harvard University
2016
Accurate methods to measure autophagic activity in vivo neurons are not available, and most of the studies based on correlative static measurements autophagy markers, leading conflicting interpretations. Autophagy is an essential homeostatic process involved degradation diverse cellular components including organelles protein aggregates. impairment emerging as a relevant factor driving neurodegeneration many diseases. Moreover, strategies modulate have been shown provide protection against...
Abstract Although protein-folding stress at the endoplasmic reticulum (ER) is emerging as a driver of neuronal dysfunction in models spinal cord injury and neurodegeneration, contribution this pathway to peripheral nerve damage remains poorly explored. Here we targeted unfolded protein response (UPR), an adaptive reaction against ER stress, mouse sciatic found that ablation transcription factor XBP1, but not ATF4, significantly delay locomotor recovery. XBP1 deficiency led decreased...
ERp57 (also known as grp58 and PDIA3) is a protein disulfide isomerase that catalyzes bonds formation of glycoproteins part the calnexin calreticulin cycle. markedly upregulated in most common neurodegenerative diseases downstream endoplasmic reticulum (ER) stress response. Despite accumulating correlative evidence supporting neuroprotective role ERp57, contribution this foldase to physiology nervous system remains unknown. Here we developed transgenic mouse model overexpresses under control...
Despite considerable progress, the mechanisms that control neural progenitor differentiation and behavior, as well their functional integration into adult circuitry, are far from being understood. Given complexity of mammalian brain, non-mammalian models provide an excellent model to study neurogenesis, including both cellular composition neurogenic microenvironment, factors required for precursor growth maintenance. In particular, we chose address question proliferation by Sonic hedgehog...
Abstract Background The increasing number of developmental events and molecular mechanisms associated with the Hedgehog (Hh) pathway from Drosophila to vertebrates, suggest that gene regulation is crucial for diverse cellular responses, including target genes not yet described. Although several high-throughput, genome-wide approaches have yielded information at genomic, transcriptional proteomic levels, specificity Gli binding sites related direct activation still remain elusive. This study...
Abstract Evidence of direct reciprocal connections between the cerebellum and basal ganglia has challenged long-held notion that these structures function independently. While anatomical studies have suggested presence cerebellar projections to substantia nigra pars compacta (SNc), nature (Cb-SNc) is unknown. Here we show Cb-SNc form monosynaptic glutamatergic synapses with both dopaminergic non-dopaminergic neurons in SNc. Optogenetic activation axons SNc rapidly increases activity,...
Abstract Parkinson’s disease (PD) is the second most common neurodegenerative condition, characterized by motor impairment due to progressive degeneration of dopaminergic neurons in substantia nigra and depletion dopamine release striatum. Accumulating evidence suggest that axons an early event disease, involving destruction programs are independent survival cell soma. Necroptosis, a programmed death process, emerging as mediator neuronal loss models diseases. Here, we demonstrate activation...
Peripheral neuropathies refer to a group of conditions in which the peripheral nervous system (PNS) is damaged. These pathological state are associated with weakness, pain, and loss motor sensory control. More than 100 types have been identified, distinct symptoms prognosis classified according type damage nerves. Injury nerves results disabling functions. Damaged axons undergo degeneration distal injury regeneration from proximal stump, fundamental process for reinnervation functional...