A5064544179- Computational Drug Discovery Methods
- Protein Structure and Dynamics
- Cytokine Signaling Pathways and Interactions
- HER2/EGFR in Cancer Research
- Synthesis and Characterization of Heterocyclic Compounds
- Malaria Research and Control
- Immune Response and Inflammation
- Bacteriophages and microbial interactions
- interferon and immune responses
- Monoclonal and Polyclonal Antibodies Research
- SARS-CoV-2 and COVID-19 Research
- Viral Infections and Immunology Research
- Chemical synthesis and alkaloids
- Chemical Synthesis and Analysis
- Organic Chemistry Cycloaddition Reactions
- Autism Spectrum Disorder Research
- Click Chemistry and Applications
- Cholinesterase and Neurodegenerative Diseases
- Tuberculosis Research and Epidemiology
- Glycosylation and Glycoproteins Research
- Metal complexes synthesis and properties
- Multicomponent Synthesis of Heterocycles
- RNA and protein synthesis mechanisms
- Analytical Chemistry and Chromatography
- Synthesis and biological activity
Amity University
2025
University of Petroleum and Energy Studies
2020-2024
Amity University
2024
The angiogenesis phenomenon is crucial for the formation of new blood vessels in cancer cells. cancerous cells' progress hampers other healthy main objective this study to explore and decipher multimodal natural compounds against VEGFR2, EphB4, FGFR-1, TIE-2 drug targets arrest progression. receptor-based pharmacophore modeling was developed validated through enrichment parameters. Further, hypothesis allowed screening druglike product databases such as SuperNatural 3.0, COCONUT, LOTUS....
As acetylcholinesterase (AChE) plays a crucial role in advancing Alzheimer’s disease (AD), its inhibition is promising approach for treating AD. Sulindac an NSAID of the aryl alkanoic acid class, consisting indene moiety, which showed neuroprotective behavior recent studies. In this study, newer Indene analogs were synthesized and evaluated their vitro AChE inhibition. Additionally, compared with donepezil as standard drug, these accessed cell line-based toxicity study on SH-SY5Y line. The...
Dual falcipain-2 (FP-2) and falcipain-3 (FP-3) inhibitors,
Extensive exploration of N-substituted carbazole derivatives is underway as these compounds possess the therapeutic potential to address neurological problems. The main aim this study synthesize a series and investigate it’s in vitro silico ability act AChE inhibitors. two-step synthesis was carried out that resulted development novel carbazoles then were subsequently subjected evaluation for acetylcholinesterase (AChE) inhibitory activity. Further comprehend binding interactions establish...
CONSPECTUS The SARS-CoV-2 viruses had made a great impact on humankind and the world economy. Phylogenetic analysis revealed newly identified B.1.617.1 B.1.617.2 lineages possessed with few key mutations predominantly circulating. signature by these are situated in RBD motif of S protein. Reports variants L452R, T478K, E484Q harbours enhancement hACE2 binding while P681R furin cleavage site resulting better transmissibility. To gain deeper understanding (L452R, T478K E484Q) hACE2, structural...
CONSPECTUS Aims The ribosomal protein (r-protein) of bacteria is composed 2.6 MDa ribonucleoproteins the 30S and 50S subunits, which are essential elements for translation. translational initiation step an intensive regulated multi-step reaction in biosynthesis. During bacterial synthesis, correct reading frame mRNA defines when initiator fMet-tRNAiMet binds to start codon AUG at P-site subunit. formation subunit complex (30S-IC) governed by three ubiquitous factors (IFs) such as IF1, IF2,...