A5073365586- Radiopharmaceutical Chemistry and Applications
- Computational Drug Discovery Methods
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Neuroendocrine Tumor Research Advances
- Mobile Health and mHealth Applications
- Chemical synthesis and alkaloids
- Cholinesterase and Neurodegenerative Diseases
- Medical Imaging Techniques and Applications
- Mosquito-borne diseases and control
- Essential Oils and Antimicrobial Activity
- Sex work and related issues
- Synthesis and Catalytic Reactions
- Malaria Research and Control
- Nanoparticle-Based Drug Delivery
- Phytochemistry and Biological Activities
- Phytochemicals and Antioxidant Activities
- Ethnobotanical and Medicinal Plants Studies
- Tuberculosis Research and Epidemiology
- Phenothiazines and Benzothiazines Synthesis and Activities
- Pharmacological Effects of Natural Compounds
- Lung Cancer Research Studies
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Skin Diseases and Diabetes
- Animal Ecology and Behavior Studies
- Diverse Scientific Research Studies
Dehradun Institute of Technology University
2022-2024
Weatherford College
2024
The Graduate Center, CUNY
2022
Manipal Academy of Higher Education
2022
Augusta University
2022
Berhampur University
2021
Sriram Chandra Bhanja Medical College Hospital
2021
Indian Institute of Chemical Biology
2011-2019
Veer Surendra Sai Medical College and Hospital
2015-2016
Institute of Medical Sciences
2014-2016
A practical copper-catalyzed, 2-picolinamide-directed ortho C-H amination of anilines with benzoyl-protected hydroxylamines has been disclosed that proceeds smoothly without any external stoichiometric oxidant or additives. Remarkably, besides anilines, bicyclic naphthyl heterocyclic amines furnished products five- and six-membered cyclic acyclic at the position selectively. This electrophilic also in water under slightly modified reaction conditions.
As acetylcholinesterase (AChE) plays a crucial role in advancing Alzheimer’s disease (AD), its inhibition is promising approach for treating AD. Sulindac an NSAID of the aryl alkanoic acid class, consisting indene moiety, which showed neuroprotective behavior recent studies. In this study, newer Indene analogs were synthesized and evaluated their vitro AChE inhibition. Additionally, compared with donepezil as standard drug, these accessed cell line-based toxicity study on SH-SY5Y line. The...
Severe cholestatic jaundice may complicate with bile cast nephropathy (BCN) causing severe acute kidney injury (AKI). In this study, we investigate BCN in falciparum malaria complicated and AKI. This prospective study was conducted a tertiary health care institution high prevalence of malaria. A cohort 110 patients cerebral malaria, AKI were enrolled. Species diagnosis made from peripheral blood smear or rapid diagnostic test. diagnosed WHO criteria. the detection casts urine biopsy. The...
Radiolabeled somatostatin analogs have become powerful tools in the diagnosis and staging of neuroendocrine tumors, which express receptors. The aim this study was to evaluate a new analog, 6-hydrazinopyridine-3-carboxylic acid-Ser3-octreotate (HYNIC-SATE) radiolabeled with 99mTc, using ethylenediamine-N,N'-diacetic acid tricine as coligands, be used radiopharmaceutical for vivo imaging receptor subtype 2 (SSTR2)-positive tumor. Synthesis peptide carried out on solid phase standard Fmoc...
AIM: Finding the prevalence of hypothyroidism in PCOS and to determine association between various clinical laboratory parameters PCOS. SETTING:The study was conducted as a prospective observational on 196 USG diagnosed cases who attended outpatient wing MKCG Medical College Hospital, Berhampur, Odisha, India.METHODS: All proven were subjected investigations like FSH, LH, FBS, PPBS, Serum Insulin, TSH, Free T3, T4.After an overnight fasting, basal venous blood sample taken.TFT including T3...
Background: The burden of chronic obstructive pulmonary disease to patients, their caretakers, and health system is gradually increasing associated with the morbidity, mortality, disability adjusted life years higher costs. Self-management COPD a vital strategy for its management. This study aims develop, implement, evaluate an informatics platform home-based self-management Chronic Obstructive Pulmonary Disease. Method: A systematic review will be conducted synthesize appraise evidence on...
Leading pathological markers of Alzheimer's disease (AD) include Acetylcholinesterase (AChE), Butyrylcholinesterase (BuChE), Amyloid beta (Aβ) and reactive oxygen species (ROS). Indole derivatives were identified optimized to improve the potency against AChE, BuChE, Aβ ROS. The lead molecule IND-30 was found be selective for AChE (selectivity ratio: 22.92) in comparison BuChE showed maximum inhibition potential human (IC
We showed solvent- and concentration-triggered chiral tuning of the fibrous assemblies two novel glycoconjugates Z-P(Gly)-Glu Z-F(4-N)-Glu made by chemical attachment Cbz-protected [short as Z)] non-proteinogenic amino acids L-phenylglycine P(Gly)] 4-Nitro-L-phenylalanine F(4-N)] with D-glucosamine Glu]. Both biomimetic gelators can form self-healing shape-persistent gels a very low critical gelator concentration in water well various organic solvents, indicating they are ambidextrous...
Proteins and peptides possess considerable potential in treating solid tumors because of their unique properties. At present, there are over 100 peptide-based formulations on the market. Today, proteins more demand due to selective nature high target-binding efficiency. Targeting with compounds molecular weight less than 10 kDa much desirable they undergo excessive penetration view fact that small sized. The have thick tissues interstitial fluid pressure, which cannot enter. properties...
Background: Objective of current study was to evaluate cervical length by transabdominal and transvaginal ultrasonography at 14-24 weeks gestation in asymptomatic women for predicting risk preterm delivery find out the one method which is more accurate two. Methods: Fifty were enrolled this prospective study. Women with incompetence, multiple gestation, maternal medical diseases, previous surgery excluded. Each woman underwent a ultrasonographic measurement. The period these then correlated...
AbstractHedychium spicatum is a perennial shrub that commonly found in the Himalayan region. Thin layer chromatography fingerprint screening of various Hedychium species revealed only possesses hedychenone. Purification and isolation hedychenone was carried out from methanolic extract rhizomes powder using column chromatography. After crystallization enriched fraction, 2.19% crystalline yielded. The physiochemical, pharmacokinetic, pharmacodynamic evaluation active pharmaceutical components...
Hedychium spicatum rhizomes is widely used in ayurvedic medicine and traditional systems around the Himalayas. Standardization of rhizome SCFE extract by Identification, Isolation, characterization, screening pharmacological activity phytoconstituents. Supercritical fluid extraction, column chromatography, spectroscopic analysis, in-silico, in-vivo study compound 1 (3-((E) -2-((1S,8aR)-3,5,5,8a-tetramethyl-4-oxo-1,4,4a,5,6,7,8,8a-octahydro-naphthalen-1-yl) vinyl) furan-2(5H)-one). A...