A5081674835- Computational Drug Discovery Methods
- Nanoparticle-Based Drug Delivery
- Cholinesterase and Neurodegenerative Diseases
- Graphene and Nanomaterials Applications
- Phytochemicals and Antioxidant Activities
- Chemical synthesis and alkaloids
- Medicinal Plants and Neuroprotection
- Gastrointestinal motility and disorders
- Tryptophan and brain disorders
- Antibiotics Pharmacokinetics and Efficacy
- Alzheimer's disease research and treatments
- Diverse Scientific Research Studies
- Advanced Chemical Sensor Technologies
- Enzyme function and inhibition
- Bacteriophages and microbial interactions
- Bee Products Chemical Analysis
- Psoriasis: Treatment and Pathogenesis
- Synthesis and biological activity
- Seed and Plant Biochemistry
- Transgenic Plants and Applications
- Advancements in Transdermal Drug Delivery
- Antibiotic Use and Resistance
- Consumer Attitudes and Food Labeling
- Microscopic Colitis
- Food Quality and Safety Studies
University of Petroleum and Energy Studies
2022-2024
Amity University
2024
Devi Ahilya Vishwavidyalaya
2022-2023
Monash University Malaysia
2017
As acetylcholinesterase (AChE) plays a crucial role in advancing Alzheimer’s disease (AD), its inhibition is promising approach for treating AD. Sulindac an NSAID of the aryl alkanoic acid class, consisting indene moiety, which showed neuroprotective behavior recent studies. In this study, newer Indene analogs were synthesized and evaluated their vitro AChE inhibition. Additionally, compared with donepezil as standard drug, these accessed cell line-based toxicity study on SH-SY5Y line. The...
The development of highly nutritious bakery products with optimum utilization food waste is a major challenge for the industry. sustainable goal country important growth nation. aim present work to prepare value-added composite flour-mixed bread from fruit and vegetables. flour was prepared in four formulations peel pomace wheat (PPWF), as PPWF1, PPWF2, PPWF3, PPWF4. Composite blended mix vegetable powders whole flour. Indian gooseberry powder, apple bottle gourd potato powder were used make...
Development of high nutritious bakery products with optimum utilization food waste is a major challenge for industries. Food in an each country. The sustainable development goal country important ant growth the nation. aim present work to prepare value-added composite flour mixed bread from wastes fruit and vegetables. was prepared four formulations Peel Pomace Wheat Flour (PPWF), as PPWF1, PPWF2, PPWF3 PPWF4. Compositing blended by mix vegetable fruits pomace powders whole wheat flour....
Leading pathological markers of Alzheimer's disease (AD) include Acetylcholinesterase (AChE), Butyrylcholinesterase (BuChE), Amyloid beta (Aβ) and reactive oxygen species (ROS). Indole derivatives were identified optimized to improve the potency against AChE, BuChE, Aβ ROS. The lead molecule IND-30 was found be selective for AChE (selectivity ratio: 22.92) in comparison BuChE showed maximum inhibition potential human (IC
Introduction: The use of alcohol as an excipient in pharmaceutical preparations raises safety concerns, especially when used high concentration. This study aims to scrutinize the ethanol concentration traditional herbal cough syrups available over-the-counter (OTC) Malaysia. Method: Enzymatic analysis was adopted estimate contents five selected syrups. principle reaction involved oxidation by nicotinamide-adenine dinucleotide (NAD) presence enzyme dehydrogenase (ADH), forming acetaldehyde,...
Proteins and peptides possess considerable potential in treating solid tumors because of their unique properties. At present, there are over 100 peptide-based formulations on the market. Today, proteins more demand due to selective nature high target-binding efficiency. Targeting with compounds molecular weight less than 10 kDa much desirable they undergo excessive penetration view fact that small sized. The have thick tissues interstitial fluid pressure, which cannot enter. properties...
Background: Torpedo californica acetylcholinesterase (TcAChE) is an important drug development target for Alzheimer's disease (AD) therapeutics. The current in silico study aims to recognise indene methylene-derived compounds acting against TcAChE gain insight into the molecular interactions. Objective: focused on identifying novel inhibitors by virtual screening, docking, drug-likeness, simulation, and DFT profile anti-Alzheimer's activity. Methods: Molecular ADMET were performed having...