A5002487199- Radiopharmaceutical Chemistry and Applications
- Medical Imaging Techniques and Applications
- RNA Interference and Gene Delivery
- Neuroendocrine Tumor Research Advances
- Nanoparticle-Based Drug Delivery
- Peptidase Inhibition and Analysis
- MicroRNA in disease regulation
- Nanoplatforms for cancer theranostics
- Cancer Treatment and Pharmacology
- Cancer Mechanisms and Therapy
- Glioma Diagnosis and Treatment
- Phagocytosis and Immune Regulation
- Immunotherapy and Immune Responses
- Cancer, Hypoxia, and Metabolism
- Circular RNAs in diseases
- Autophagy in Disease and Therapy
- TGF-β signaling in diseases
- Immune cells in cancer
- Wnt/β-catenin signaling in development and cancer
- Cancer Cells and Metastasis
- Cancer therapeutics and mechanisms
- Lung Cancer Research Studies
- Liver Disease Diagnosis and Treatment
- Advancements in Transdermal Drug Delivery
- Protein Degradation and Inhibitors
Indian Institute of Technology Kharagpur
2018-2023
Techno India Group (India)
2022-2023
Virginia Commonwealth University
2021-2022
Indian Institute of Chemical Biology
2012-2020
Council of Scientific and Industrial Research
2012-2019
There is a pressing need for ubiquitously expressed antigen or receptor on the tumor surface successful mitigation of deleterious side effects chemotherapy. Phosphatidylserine (PS), normally constrained to intracellular surface, exposed external tumors and most tumorigenic cell lines. Here we report that novel PS-targeting liposome, phosphatidylcholine-stearylamine (PC-SA), induced apoptosis showed potent anticancer as single agent against majority cancer We experimentally proved this was...
Somatostatin receptor (SSTR) analog modified nanoparticles of paclitaxel (PSM) showed a superior anti-melanoma effect by inducing favorable systemic immune response.
Significance No current therapies prevent recurrence in patients with glioblastoma multiforme (GBM). Extracellular matrix (ECM) remodeling and epithelial mesenchymal transition (EMT) are important processes regulating GBM progression acquisition of radiation temozolomide (radio/TMZ) resistance. Fli-1 choreographs ECM EMT via transcriptional regulation HSPB1. Lumefantrine, an antimalarial drug, inhibits the activities its downstream targets HSPB1, remodeling, EMT. Lumefantrine is selectively...
Microbial lipopeptide “Iturin A” is a versatile bio-active molecule with potent antitumor action. Pre-clinical study of this showed very minimum toxicity in rodent model.
Radiolabeled somatostatin analogs have become powerful tools in the diagnosis and staging of neuroendocrine tumors, which express receptors. The aim this study was to evaluate a new analog, 6-hydrazinopyridine-3-carboxylic acid-Ser3-octreotate (HYNIC-SATE) radiolabeled with 99mTc, using ethylenediamine-N,N'-diacetic acid tricine as coligands, be used radiopharmaceutical for vivo imaging receptor subtype 2 (SSTR2)-positive tumor. Synthesis peptide carried out on solid phase standard Fmoc...