A5100624804- TGF-β signaling in diseases
- Bone Metabolism and Diseases
- Gold and Silver Nanoparticles Synthesis and Applications
- Cancer-related Molecular Pathways
- Bone Tissue Engineering Materials
- Mesenchymal stem cell research
- Oral and Maxillofacial Pathology
- Microtubule and mitosis dynamics
- Protein Tyrosine Phosphatases
- Growth Hormone and Insulin-like Growth Factors
- Monoclonal and Polyclonal Antibodies Research
- Climate Change and Health Impacts
- Cancer Cells and Metastasis
- Bone and Joint Diseases
- Nuclear Structure and Function
- Axon Guidance and Neuronal Signaling
- Nanofabrication and Lithography Techniques
- Ubiquitin and proteasome pathways
- Orthodontics and Dentofacial Orthopedics
- dental development and anomalies
Fudan University
2022-2025
Peking University
2020-2024
Beijing Jishuitan Hospital
2022
Shanghai Stomatological Hospital
2022
National Clinical Research Center for Digestive Diseases
2020
King University
2020
The E3 ubiquitin ligase complex CDC20-activated anaphase-promoting complex/Cyclosome (APC/CCDC20 ) plays a critical role in governing mitotic progression by targeting key cell cycle regulators for degradation. Cell division protein 20 homolog (CDC20), the co-activator of APC/C, is required full activity. In addition to its well-known cycle-related functions, we demonstrate that CDC20 an essential osteogenic commitment bone marrow mesenchymal stromal/stem cells (BMSCs). Cdc20 conditional...
Abstract Dual-specificity phosphatases (DUSPs) are defined by their capability to dephosphorylate both phosphoserine/phosphothreonine (pSer/pThr) and phosphotyrosine (pTyr). DUSP5, a member of DUSPs superfamily, is located in the nucleus plays crucially regulatory roles signaling pathway transduction. In our present study, we discover that DUSP5 significantly promotes osteogenic differentiation mesenchymal stromal cells (MSCs) activating SMAD1 pathway. Mechanistically, physically interacts...
Bone defects and fractures heal slowly compared with injuries to other tissues, creating a heavy burden for patients, their families, society. Alongside conventional treatment methods bone defects, adjuvant therapies play an important but underappreciated role. In previous study, we found that systemic administration of flufenamic acid promoted osteogenesis in vivo, its side effects limited the application our findings. present assess external butyl flufenamate ointment on healing cranial...
ABSTRACT Managing orthodontic treatment for adults with missing permanent teeth can be intricate, especially when dealing a posterior scissor bite and an impacted tooth. This case report presents successful of female patient dental skeletal Class II malocclusion, high mandibular plane angle, maxillary left lateral incisor right first molar, as well bite, deeply second premolar. In the maxilla, molar were strategically extracted to eliminate enhance frontal esthetic balance. mandible,...
There is a balance between adipogenic differentiation and osteogenic of human adipose-derived stem cells (hASCs). It essential to explore the mechanism hASCs lineage commitment. In our previous study, UNC-5 netrin receptor B (UNC5B) was identified as positive regulator for osteogenesis.To further potential roles mechanisms UNC5B during provide new method regulate adipogenesis osteogenesis hASCs.Lentivirus containing shRNA used knockdown. Plasmids overexpressing gene were upregulation. To...
Abstract BackgroundMitochondrial phosphoenolpyruvate carboxykinase (PCK2) is a rate-limiting enzyme that plays critical roles in multiple physiological processes. We unveiled the important role of PCK2 on regulation osteogenesis by mesenchymal stromal/stem cells (MSCs) our previous work. Here we further investigated regulating adipogenesis MSCs and its therapeutic effect osteoporosis. MethodsWe function adipogenic differentiation vitro through loss-and-gain-of-function experiments. This was...
BackgroundStudies on the associations between temperature and osteoporotic fractures (OF) hospitalizations are limited. This study aims to assess short-term effect of apparent (AT) risk OF in Beijing, China.MethodsDaily hospitalizations, meteorological factors air pollutants Beijing from 2004 2021 were collected. A Poisson generalized linear regression model combined with a distributed lag non-linear was applied analyze lag-exposure-response relationship AT number hospitalizations. Subgroup...