A5033024658- Bone Metabolism and Diseases
- Single-cell and spatial transcriptomics
- TGF-β signaling in diseases
- Bone Tumor Diagnosis and Treatments
- Liver Disease Diagnosis and Treatment
- Diet and metabolism studies
- Pancreatic and Hepatic Oncology Research
- Rheumatoid Arthritis Research and Therapies
- Liver physiology and pathology
- Cytokine Signaling Pathways and Interactions
- Liver Disease and Transplantation
- Immune cells in cancer
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cell Adhesion Molecules Research
- Gut microbiota and health
- Immune responses and vaccinations
Osaka University
2023-2024
National Institute of Biomedical Innovation, Health and Nutrition
2024
Ube Frontier University
2024
Abstract Alveolar macrophages (AMs) are crucial for maintaining normal lung function. They abundant in cancer tissues, but their pathophysiological significance remains unknown. Here we show, using an orthotopic murine model and human carcinoma samples, that AMs support cell proliferation thus contribute to unfavourable outcome. Inhibin beta A (INHBA) expression is upregulated under tumor-bearing conditions, leading the secretion of activin A, a homodimer INHBA. Accordingly, follistatin,...
Cholesteatoma, which potentially results from tympanic membrane retraction, is characterized by intractable local bone erosion and subsequent hearing loss brain abscess formation. However, the pathophysiological mechanisms underlying destruction remain elusive. Here, we performed a single-cell RNA sequencing analysis on human cholesteatoma samples identify pathogenic fibroblast subset abundant expression of inhibin βA. We demonstrate that activin A, homodimer βA, promotes osteoclast...
Abstract Background Rheumatoid arthritis (RA) is characterized by chronic inflammation and resultant cartilage/bone destruction because of aberrantly activated osteoclasts. Recently, novel treatments with several Janus kinase (JAK) inhibitors have been shown to successfully ameliorate arthritis-related bone erosion, although their mechanisms action for limiting remain unclear. Here, we examined the effects a JAK inhibitor on mature osteoclasts precursors intravital multiphoton imaging....
Neuron-associated macrophages, shortly NAMs, are one of macrophage subsets which exists on peripheral neurons. NAMs have been identified in various organs including the intestine, skin, lung and adipose tissues. responsible for maintaining tissue integrity through protecting neurons regulating immune system. We also newly found out a NAM subset liver, especially portal vein. The vein is most pivotal feeding vessel transports food-derived nutrients from gastrointestinal tract to liver....