A5086104310- Blood Coagulation and Thrombosis Mechanisms
- Hemophilia Treatment and Research
- Venous Thromboembolism Diagnosis and Management
- Neonatal and fetal brain pathology
- Platelet Disorders and Treatments
- Central Venous Catheters and Hemodialysis
- Respiratory and Cough-Related Research
- Case Reports on Hematomas
- Cardiovascular Issues in Pregnancy
- Vascular anomalies and interventions
- Pregnancy and preeclampsia studies
- Sepsis Diagnosis and Treatment
- Healthcare cost, quality, practices
- Antibiotic Use and Resistance
- Traumatic Brain Injury and Neurovascular Disturbances
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Ectopic Pregnancy Diagnosis and Management
- Hematological disorders and diagnostics
- Hemoglobinopathies and Related Disorders
- Preterm Birth and Chorioamnionitis
- Streptococcal Infections and Treatments
- Maternal and fetal healthcare
- Endometriosis Research and Treatment
- Cancer-related gene regulation
- Patient Satisfaction in Healthcare
University of Colorado Anschutz Medical Campus
2017-2024
University of Colorado Denver
2018-2022
Children's Hospital Colorado
2017-2021
Thornhill Medical (Canada)
2019
<h3>Abstract</h3> <b>Objective:</b> To assess whether sharing the uncertainty of value antibiotics for acute bronchitis in form written and verbal advice affects likelihood patients taking antibiotics. <b>Design:</b> Nested, single blind, randomised controlled trial. <b>Setting:</b> Three suburban general practices Nottingham. <b>Participants:</b> 259 previously well adults presenting with bronchitis. <b>Intervention:</b> In group A, 212 were judged by their practitioner not to need that day...
Abstract The Joint Outcome Study (JOS), a randomized controlled trial, demonstrated that children with severe hemophilia A (HA) initiating prophylactic factor VIII (FVIII) prior to age 2.5 years had reduced joint damage at 6 compared those treated episodic FVIII for bleeding. Continuation (JOS-C) evaluated early vs delayed prophylaxis effects on long-term health, following JOS participants 18 in an observational, partially retrospective study. Index magnetic resonance imaging (MRI) scores of...
Emicizumab, a bispecific antibody factor VIII mimetic, is approved for prophylaxis in hemophilia, and has different risks side effects compared to products.
Preeclampsia is both a vascular and inflammatory disorder. Since the placenta conduit for fetal development, preeclampsia should be presumed cause of adverse infant outcomes. Yet, relationship placental pathology, inflammation neurological outcomes after are understudied. We prospectively examined cohort maternal-infant dyads with maternal cytokines at time diagnosis delivery, cord blood (IL-1β, IL-6, IL-8, TNF-α). Placentas were analyzed pathologies. Neurodevelopmental assessment infants...
Venous thromboembolism (VTE) is a highly morbid condition with several available oral anticoagulant treatment options. Numerous studies have been published comparing warfarin to direct anticoagulants; however, populations remain underrepresented in these reports. We surveyed members of The ThromboEmbolism Network U.S. working group regarding their preferences for the VTE different and challenging populations. In individuals no other medical comorbidities, respondents preferred either...
The Colorado Adult Joint Assessment Scale (CAJAS) is designed to assess joint health in adults with hemophilia. CAJAS comprises nine items (swelling, muscle atrophy, axial deformity, crepitus, range of motion, contracture, instability, strength, gait) and assesses six joints.To content validity psychometric properties.Data were obtained from the Trial Evaluate Effect Secondary Prophylaxis With rFVIII Therapy Severe Hemophilia A and/or Adolescent Subjects Compared That Episodic Treatment...
Background and Objectives: Venous thromboembolic events (VTE) complicate acute hematogenous musculoskeletal infections (MSKIs) among hospitalized children. However, there is limited guidance for which specific MSKI patients are at the greatest VTE risk. This study aimed to identify risk factors children with MSKIs. Methods: A retrospective chart review was performed of MSKIs a single quaternary care pediatric hospital during 9-year period. Patients chronic MSKIs, non-hematogenous infections,...
Abstract Background There is need for validated outcome measures postthrombotic syndrome (PTS) following pediatric venous thromboembolism (VTE), with a focus on quality of life (QoL). Aims This article assesses reliability and validity two PTS QoL scales children lower extremity VTE. Methods Pediatric patients VTE were recruited from three thrombosis clinics. The Manco–Johnson (MJ) the modified Villalta (MV) compared each other generic health-related QoL, PedsQL, newly developed...
Introduction: Impaired psychosocial health after stroke in adults is well established, with high prevalence of post-stroke anxiety and depression. Behavioral following pediatric less described. Early data suggest that patients may experience higher rates anxiety, depression, ADHD PTSD. detection treatment behavioral concerns can lead to improved outcomes. However, screening measures assess functioning have not yet been explored. Methods: This single-center retrospective cohort study (COMIRB...