A5009723064- Asthma and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Tracheal and airway disorders
- Allergic Rhinitis and Sensitization
- Lung Cancer Diagnosis and Treatment
- Cystic Fibrosis Research Advances
- Food Allergy and Anaphylaxis Research
- Medical Imaging and Pathology Studies
- Studies on Chitinases and Chitosanases
- Respiratory and Cough-Related Research
- Health and Well-being Studies
- Infection Control and Ventilation
- Health disparities and outcomes
- Pericarditis and Cardiac Tamponade
- Nosocomial Infections in ICU
- Innovations in Medical Education
- Nematode management and characterization studies
- Radiology practices and education
- Hemophilia Treatment and Research
- Respiratory Support and Mechanisms
- Airway Management and Intubation Techniques
- Infective Endocarditis Diagnosis and Management
- Health, psychology, and well-being
- Clinical Reasoning and Diagnostic Skills
- Takotsubo Cardiomyopathy and Associated Phenomena
Singapore General Hospital
2012-2023
Duke-NUS Medical School
2017-2023
Mount Elizabeth Novena Hospital
2021-2022
University of Colorado Anschutz Medical Campus
2021
University of Southampton
2021
SingHealth
2017
Applied Radar (United States)
2013
St. Paul's Hospital
2007
Severe asthma is a largely heterogeneous disease with varying phenotypic profiles. The relationship between specific allergen sensitization and severity, particularly in Asia, remains unclear. We aim to study the prevalence of patterns investigate their association outcomes severe cohort an Asian setting.We conducted cross-sectional patients receiving step 4 or 5 Global Initiative for Asthma treatment. Univariate multivariate analyses were performed assess identifiable by skin prick test...
Emicizumab, a bispecific antibody factor VIII mimetic, is approved for prophylaxis in hemophilia, and has different risks side effects compared to products.
Asthma is a chronic inflammatory airway disease, for which the cornerstone of asthma therapy inhaled corticosteroids.however, long term clinical outcomes are variable, and not all patients respond optimally to corticosteroids.Underpinning this observation that heterogeneous disease consisting phenotypes driven by different pathways.In article, we will discuss mechanisms better define patient characteristics help improve with newer specific-targeted therapies.
Current data for the utility of radial endobronchial ultrasound (EBUS) in investigating peripheral lung lesions (PLLs) has been restricted to populations with low pulmonary tuberculosis (TB) incidence. The aim this study was assess diagnostic EBUS guide sheath diagnosis Singapore, a high TB incidence setting.A post-hoc database analysis performed. 123 consecutive patients computed tomographic evidence PLLs who underwent guided bronchoscopy were included.The final malignancy 76 cases and...
Filaggrin loss-of-function (FLG-LOF) mutations are an established genetic cause of eczema. These have subsequently been reported to increase the risk aeroallergen sensitization and allergic airway disease. However, it is unclear whether FLG variants require both eczema influence disease development long-term outcomes.To examine effects FLG-LOF on outcomes, with as intermediate variables, using Isle Wight birth cohort.Study participants were evaluated at ages 1, 2, 4, 10 18 years ascertain...
As part of ongoing quality improvement initiatives, the Canadian Standards for Psychiatric‐Mental Health Nursing were recently revised. For first time since standards published in 1995, input consumers mental health services was sought. Thirty‐one from across Canada participated focus groups, and answered questions related to domains practice as identified document. Through this input, able inform committee regarding areas satisfaction dissatisfaction their unique perspective. article,...
Abstract Background Childhood food allergy (FA) and allergen sensitization (FAS) are associated with allergic airway disease(s) [AAD] (asthma rhinitis) in childhood. However, the associations between childhood FA/FAS AAD adulthood not well described. Methods We investigated longitudinal relationship to common allergens at 18 26 years, Isle of Wight birth cohort. Study subjects ( N = 1456) were followed up fixed time points from ages 1–26 years for status. evaluated 4 onwards. The assessed...
Psychological impairment, such as anxiety and depression, is common in severe asthma. However, the impact of psychological impairment on asthma-specific quality life (ASQOL) work has not been assessed within Southeast-Asia. Furthermore, previous ASQOL questionnaires contained items overlapping with asthma control, making it challenging to isolate relationship between respectively.To evaluate asthma.This a cross-sectional study at Singapore General Hospital. We ASQOL, control using validated...
Hypersensitivity to nonsteroidal anti-inflammatory drugs (NSAIDs) may limit the use of aspirin in patients with cardiovascular diseases. Aspirin desensitization, which is a resource-intensive process, can offer such access through induction temporary tolerance aspirin. However, there limited information on desensitization response undergoing for cardiac indications Asia.To characterize who have undergone evaluate their responses procedure, and identify risk factor(s) associated failure...
<b>Background:</b> Previous studies psychological comorbidity in asthma using cross-sectional/retrospective methods. We prospectively evaluated the effects of on asthma-related health outcomes. <b>Methods:</b> 354 patients with severe were followed-up longitudinally. Outcomes interest were: emergency visits, hospital admissions, life-threatening attacks and symptoms. 72 also underwent evaluation Hospital Anxiety Depression Scale (HADS) Nijmegen questionnaire. <b>Results:</b> The prevalence...
We report a 68-year-old female who presented with chronic cough and progressive dyspnoea. Computed tomography of the thorax subsequent bronchoscopy confirmed diagnosis pulmonary alveolar proteinosis (PAP), which was treated whole lung lavage. This case is reported in view low incidence PAP.
<b>Introduction:</b> The diagnostic yield of bronchoscopic lung biopsy for peripheral lesions is approximately 60%. Virtual navigation (VBN) aims to improve diagnosis by using 3D CT-reconstruction plan a route the lesion. <b>Objective:</b> To assess VBN compared conventional bronchoscopy lesions. <b>Methods:</b> Prospective non-randomized single-institution, case series consecutive cases (n=200) from July 2013 December 2016 <b>Results:</b> Patient/procedure characteristics are shown in Table...
This abstract is funded by: Observational & Pragmatic Research Institute Pte Ltd, and Circassia Presented at thematic poster session: A34 ASTHMA CLINICAL STUDIES I Sunday 20th May
Previous studies examining successful aging often incorporated arbitrary measures and thresholds to define agers, resulted in the prevalence of agers ranging from 0.4% 95%. Longitudinal that would enable testing indexes against mortality are also lacking. We aim operationalize construct by using empirical approach. First, we a list indicators after reviewing proposed models. ran principal component analysis (PCA) on these data nationally representative sample older Singaporean adults (≥ 60...