A5008863035- Advancements in Transdermal Drug Delivery
- Bee Products Chemical Analysis
- Dermatology and Skin Diseases
- Polymer-Based Agricultural Enhancements
- Polymer Surface Interaction Studies
- Advanced Drug Delivery Systems
- Immunotherapy and Immune Responses
- Photoreceptor and optogenetics research
- Polydiacetylene-based materials and applications
- Chemical and Physical Properties in Aqueous Solutions
- Synthesis and properties of polymers
- Characterization and Applications of Magnetic Nanoparticles
- Brain Metastases and Treatment
- Groundwater flow and contamination studies
- Crystallization and Solubility Studies
- Advanced oxidation water treatment
- Advanced Photocatalysis Techniques
- Photochromic and Fluorescence Chemistry
- Atomic and Subatomic Physics Research
- Pesticide and Herbicide Environmental Studies
- Rheumatoid Arthritis Research and Therapies
- Glioma Diagnosis and Treatment
- Nanoparticle-Based Drug Delivery
- Action Observation and Synchronization
- Toxin Mechanisms and Immunotoxins
Zhejiang University of Technology
2020-2024
Shandong Agricultural University
2023
University of Duisburg-Essen
2021
Ningbo Polytechnic
2021
Shaoxing City Women and Children Hospital
2018
Chang Gung University
2017
Taizhou University
2016
Increasingly attention has been paid to the transdermal drug delivery systems with microneedles owing their excellent compliance, high efficiency, and controllable release, therefore, become promising alternative tremendous advantages for delivering specific drugs such as huperzine A (Hup A) treatment of Alzheimer's disease (AD) yet low oral bioavailability. The purpose present study is design, prepare, evaluate a dissolving microneedle patch (DMNP) system Hup A, investigating its in vitro...
As for wound drug delivery, microneedles (MNs) have attracted wide attention. However, while effective at increasing the depth of traditional MNs often limited loads and difficulty penetrating scabs on wounds. Herein, we develop a delivery system combining MgO@polydopamine (MgO@PDA) nanoparticle-loaded photothermal MN patches chitosan (CS) gel to inhibit formation deliver sufficient drugs into deep tissue. When inserted wound, can keep bed moist weakly acidic accelerate closure. The released...
In this study, a micro-molding technology was used to prepare the microneedles (MNs), while texture analyzer measure its Young’s modulus, Poisson’s ratio and compression breaking force, evaluate whether MNs can penetrate skin. The effects of different materials were characterized by their ability withstand stresses using Structural Mechanics Module COMSOL Multiphysics. Carboxymethylcellulose (CMC) chosen as needle formulation material with varying quantities polyvinyl pyrrolidone (PVP),...
Conventional treatments for tumors were frequently accompanied by drawbacks and side effects. It might be useful to use the revolutionary microneedle technology which combines photothermal therapy with tumor immunotherapy. In this study, we created a drug delivery system mercapto-modified gold nanorods immune checkpoint blocker anti-PD-1 polypeptide. With good mechanical strength, can efficiently penetrate skin deliver drugs. When inserted into human skin, peptides released, boosting...
Chitosan nanoparticles (CS-NPs) are under increasing investigation for the delivery of therapeutic proteins, such as vaccines, interferons, and biologics. A large number studies have been taken on characteristics CS-NPs, very few these focused microstructure protein-loaded NPs. In this study, we prepared CS-NPs by an ionic gelation method, bovine serum albumin (BSA) was used a model protein. Dynamic high pressure microfluidization (DHPM) utilized to post-treat so improve uniformity,...
This work aims at developing a strategy to activate the antigen-presenting cells enhance effect of immunotherapy in triple-negative breast cancer (TNBC) through dissolving microneedle patch (DMNP). In present study, mannosylated chitosan (MCS) nanoparticles (NPs) were designed target dendritic (DCs), and was enhanced by adjuvant Bacillus Calmette-Guerin polysaccharide (BCG-PSN), achieving purpose transdermal for TNBC. Vaccination studies with mice demonstrated that MCS NPs effectively induce...
A novel drug monitoring method is experimentally demonstrated by optically pumped atomic magnetometer. An elliptically polarized single-beam spin-exchange-relaxation-free magnetometer (SERF AM) used to realize magnetorelaxometry (MRX) measurement and thereby quantify concentrations of superparamagnetic nanoparticles in solutions. Moreover, drug-conjugated magnetic are monitored mice for twelve hours study the sustained-release mechanism. Our results show great potential application...
A light-controlled biocatalytic one-pot system is developed, which enables precise regulation of gene expression and photocatalysis by illumination yields high conversion stereoselectivity.
Despite the non-biodegradable petrochemical polymers-coated controlled-release fertilizers have revolutionarily promoted agricultural production, more researches should be devoted to developing biodegradable starch films-packaged fertilizers. To inform development of fertilizers, water-repellent ability and characteristic films need enhanced. Here, densified starch/PBAT composite (DSCFs) with excellent water tolerance, superior performance low film materials content (1~2%) were fabricated...