A5100706234- Plant tissue culture and regeneration
- Animal Genetics and Reproduction
- Chromosomal and Genetic Variations
- Endoplasmic Reticulum Stress and Disease
- Genetic and phenotypic traits in livestock
- CRISPR and Genetic Engineering
- Genomics and Phylogenetic Studies
- Plant Virus Research Studies
- Osteoarthritis Treatment and Mechanisms
- Agricultural Systems and Practices
- Hippo pathway signaling and YAP/TAZ
- Signaling Pathways in Disease
- Bacteriophages and microbial interactions
- Xenotransplantation and immune response
- Bacterial biofilms and quorum sensing
- Genetic diversity and population structure
- Cancer Research and Treatments
- Calcium signaling and nucleotide metabolism
- Plant Pathogens and Fungal Diseases
- Plant nutrient uptake and metabolism
- Viral Infectious Diseases and Gene Expression in Insects
- Ion Channels and Receptors
- Pancreatic function and diabetes
- Muscle Physiology and Disorders
- Rangeland Management and Livestock Ecology
Shenyang Pharmaceutical University
2022-2023
Leiden University
2014-2022
Fujian Medical University
2016
First Affiliated Hospital of Fujian Medical University
2016
Binzhou University
2012
Binzhou Medical University
2012
Army Medical University
2007
Southwest Hospital
2007
Auburn University
2003
Environmental problems require the development of biodegradable plastics benign production that can be synthesized from renewable resources without use toxic and hazardous chemicals will help in solving increasing global disposal burden. Protein-based polymers offer a wide range materials similar to petroleum-based such as elastomers plastics. prepared varied design composition through genetic engineering noxious solvents made with chemical clocks set then half-lives they environmentally...
We have sequenced the complete genome of plant pathogen Agrobacterium tumefaciens strain LBA4213, a derivative wild-type A. Ach5 and ancestor LBA4404 used in genetic engineering. The consists circular chromosome linear chromosome, as well megaplasmid tumor-inducing plasmid.
Significance The soil bacterium Agrobacterium tumefaciens transforms plant cells into tumor by transferring a segment of oncogenic DNA (T-DNA). During transformation set virulence proteins is translocated the to promote transformation. We show here that one these proteins, VirD5, has capacity interfere with conserved process mitosis. By binding host protein Spt4, VirD5 accumulates in nucleus at centromeres/kinetochores. There it can cause chromosome missegregation generating aneuploid both...
The soil bacterium Agrobacterium tumefaciens is a preferred gene vector not only for plants but also fungi. delivers small set of virulence proteins into host cells concomitantly with transferred DNA (T-DNA) to support the transformation process. Here, we find that expression one these proteins, called VirD5, in yeast causes replication stress and damage. This can result both genomic rearrangements local mutations, especially deletions. Delivery VirD5 during cocultivation led mutations...
Aided by translocated virulence proteins, Agrobacterium tumefaciens transforms plant cells with oncogenic T-DNA. In the host protein VirD5 moves to nucleus, where it becomes localized at kinetochores, and disturbs faithful chromosome segregation, but molecular mechanism underlying this remains unknown. To gain more insight, we screened amongst kinetochore proteins for interactors using bimolecular fluorescence complementation assays, tested segregation in yeast cells. We found that interacts...
Silibinin is a natural flavonoid with anti-diabetic activity. Glucagon-like peptide−1 (GLP−1), an intestinal hormone mainly secreted from L cells, which regulates insulin production and sensitivity, appears to be potential therapeutic strategy for T2DM. The current study aims determine the protective effect of silibinin against palmitic acid (PA)-induced damage in GLUTag cells. results revealed that PA triggered endoplasmic reticulum (ER) stress apoptosis while attenuated PA-induced...
Abstract Silibinin is a natural extract exhibiting anti-diabetic effects. Lipotoxicty induced by excessive accumulation of free fatty acids (FFAs) leads to both insulin resistance and β cell insufficiency, which can trigger the pathogenesis type 2 diabetes mellitus (T2DM). Glucagon-like peptide-1 (GLP-1), an intestinal hormone mainly secreted from L cells, regulates production sensitivity, protection functional GLP-1 producing cells appears be potential therapeutic strategy for T2DM...