A5089056539- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- IL-33, ST2, and ILC Pathways
- Immunodeficiency and Autoimmune Disorders
- CAR-T cell therapy research
- Peptidase Inhibition and Analysis
- Immune cells in cancer
- Eosinophilic Esophagitis
- Immune Response and Inflammation
- NF-κB Signaling Pathways
- Signaling Pathways in Disease
- Antimicrobial Peptides and Activities
- Psoriasis: Treatment and Pathogenesis
- Immunotherapy and Immune Responses
- Galectins and Cancer Biology
Duke University Hospital
2017-2020
Duke Medical Center
2017-2020
Duke University
2017-2020
Amgen (United States)
2020
Abstract T helper 17 (Th17) cell plasticity contributes to both immunity and autoimmunity; however, the factors that control lineage flexibility are mostly unknown. Here we show activator protein-1 (AP-1) factor JunB is an essential regulator of Th17 identity. activates expression lineage-specifying genes coordinately represses controlling Th1 regulatory T-cell fate. supports identity by regulating key AP-1 complex constituents. In particular, limits subset repressor IRF8, impedes access...
Abstract Calcineurin is important for fungal virulence and a potential antifungal target, but compounds targeting calcineurin, such as FK506, are immunosuppressive. Here we report the crystal structures of calcineurin catalytic (CnA) regulatory (CnB) subunits complexed with FK506 FK506-binding protein (FKBP12) from human pathogens ( Aspergillus fumigatus , Candida albicans Cryptococcus neoformans Coccidioides immitis ). Fungal complexes similar to mammalian complex, comparison FKBP12...
CCR6- group 3 innate lymphoid cells (ILC3s) are mediators of intestinal immunity and barrier function that possess the capacity to acquire type 1 effector features fully convert into ILC1s. The molecular mechanisms governing such plasticity undefined. Here, we identified c-Maf as an essential regulator ILC3 homeostasis limits physiological ILC1 conversion. Phenotypic analysis status in Maf-deficient ILC3s, coupled with evaluation global changes transcriptome, chromatin accessibility,...
Pulmonary fungal infections generate heterogenous alveolar macrophage subpopulations.
Abstract Regulatory T cells (Tregs) adopt specialized phenotypes defined by coexpression of lineage-defining transcription factors, such as RORγt, Bcl-6, or PPARγ, alongside Foxp3. These Treg subsets have unique tissue distributions and diverse roles in maintaining organismal homeostasis. However, despite extensive functional characterization, the factors driving specialization are largely unknown. In this article, we show that c-Maf is a critical factor regulating process mice, essential...
Foxp3-expressing regulatory T (Treg) cells are critical mediators of immunological tolerance to both self and microbial antigens. Tregs activate context-dependent transcriptional programs adapt effector function specific tissues; however, the factors controlling tissue-specific gene expression in remain unclear. Here, we find that AP-1 transcription factor JunB regulates intestinal adaptation by select multiple Treg subsets. Treg-specific ablation results immune dysregulation characterized...
Abstract Foxp3-expressing regulatory T (Treg) cells are critical mediators of immunological tolerance to both self and microbial antigens. Tregs activate context-dependent transcriptional programs adapt effector function specific tissues; however, the factors controlling tissue-specific gene expression in remain unclear. Here, we find that AP-1 transcription factor JunB regulates intestinal adaptation by select multiple Treg subsets. Treg-specific ablation results immune dysregulation...
Abstract During an immune response, naïve CD4+ T cells encounter their cognate antigen and are induced to differentiate into one of several distinct helper (Th) subsets. Although previously regarded as lineage-committed, these differentiated subsets now appreciated exhibit a degree plasticity, whereby certain environmental stimuli permit inter-subset conversion. In particular, Th17 have been demonstrated high intrinsic plasticity capable “reprogramming” towards phenotypes typical both pro-...
Abstract Foxp3+ regulatory T cells (Tregs) must adapt to function within a wide range of tissue environments and types immune response. This flexibility is achieved through specialization, whereby context-dependent transcriptional changes integrate unique functionality into general Treg programming. In the most well-studied examples, this involves co-expression Foxp3 another “lineage-defining” transcription factor (TF) which confers expression specific functional genes. Two such specialized...