A5036869812- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
- Lysosomal Storage Disorders Research
- Dietary Effects on Health
- Lipid metabolism and disorders
- Pancreatic function and diabetes
- Lipid metabolism and biosynthesis
- Protease and Inhibitor Mechanisms
- Muscle metabolism and nutrition
- Atherosclerosis and Cardiovascular Diseases
- Liver Disease Diagnosis and Treatment
- Calcium signaling and nucleotide metabolism
- Muscle Physiology and Disorders
- Sphingolipid Metabolism and Signaling
- Peroxisome Proliferator-Activated Receptors
- Metabolism, Diabetes, and Cancer
- Calpain Protease Function and Regulation
- Endoplasmic Reticulum Stress and Disease
- Mitochondrial Function and Pathology
- Cellular transport and secretion
- Diet and metabolism studies
Medical University of Graz
2023-2024
Graz University of Technology
2018
Medical University of Vienna
2016-2018
Institute of Biochemistry
2017
In obesity, sustained adipose tissue (AT) inflammation constitutes a cellular memory that limits the effectiveness of weight loss interventions. Yet, impact fasting regimens on regulation AT immune infiltration is still elusive. Here we show intermittent (IF) exacerbates lipid-associated macrophage (LAM) inflammatory phenotype visceral in obese mice. Importantly, this increase LAM abundance strongly p53 dependent and partly mediated by p53-driven adipocyte apoptosis. Adipocyte-specific...
Abstract Obesity and type 2 diabetes mellitus have reached an epidemic level, thus novel treatment concepts need to be identified. Myostatin, a myokine known for restraining skeletal muscle growth, has been associated with the development of insulin resistance mellitus. Yet, little is about regulation myostatin in human obesity resistance. We aimed investigate uncover potential associations between myostatin, metabolic markers resistance/sensitivity indices. Circulating active concentration...
The metabolic syndrome is becoming increasingly prevalent in the general population that at simultaneous risk for both type 2 diabetes and cardiovascular disease. critical pathogenic mechanisms underlying these diseases are obesity-driven insulin resistance atherosclerosis, respectively. To obtain a better understanding of molecular involved pathogenesis as basis future treatment strategies, studies considering inherent risks, namely cardiovascular, needed. Hence, aim this study was to...
Elevated circulating fatty acids (FAs) contribute to obesity-associated metabolic complications, but the mechanisms by which insulin suppresses lipolysis are poorly understood. We show that α/β-hydrolase domain-containing 15 (ABHD15) is required for anti-lipolytic action of in white adipose tissue (WAT). Neither nor glucose treatments can suppress FA mobilization global and conditional Abhd15-knockout (KO) mice. Accordingly, signaling impaired Abhd15-KO adipocytes, as indicated reduced AKT...
To date, the only enzyme known to be responsible for hydrolysis of cholesteryl esters and triacylglycerols in lysosome at acidic pH is lysosomal acid lipase (LAL). Lipid malabsorption small intestine (SI), accompanied by macrophage infiltration, one most common pathological features LAL deficiency. However, exact role intestinal lipid metabolism still unknown. We collected three parts SI (duodenum, jejunum, ileum) from mice with a global (LAL KO) or intestine-specific deletion (iLAL...
Abstract Background Matrix metalloproteinase 12 (MMP12) is a macrophage-secreted protein that massively upregulated as pro-inflammatory factor in metabolic and vascular tissues of mice humans suffering from cardiometabolic diseases (CMDs). However, the molecular mechanisms explaining contributions MMP12 to CMDs are still unclear. Methods We investigated impact deficiency on mouse model mimics human disease by simultaneously developing adipose tissue inflammation, insulin resistance,...
Obesity is strongly associated with metabolic syndrome, a combination of risk factors that predisposes to development the cardiometabolic diseases: atherosclerotic cardiovascular disease and type 2 diabetes mellitus. Prevention syndrome requires novel interventions address this health challenge. The objective study was identify candidate molecules for prevention treatment insulin resistance atherosclerosis, conditions underlie mellitus disease, respectively. We used an unbiased...
Abstract Background Activation of brown adipose tissue (BAT) has gained attention due to its ability dissipate energy and counteract cardiometabolic diseases (CMDs). Methods This study investigated the consequences cold exposure on BAT liver proteomes an established CMD mouse model based LDL receptor-deficient (LdlrKO) mice fed a high-fat, high-sucrose, high-cholesterol diet for 16 weeks. We analyzed metabolism in vivo performed untargeted proteomics LdlrKO maintained at 22 °C or 5 7 days....
Lysosomal acid lipase (LAL) is the only known enzyme that degrades cholesteryl esters and triglycerides at an acidic pH. In LAL deficiency (LAL-D), dysregulated expression of matrix metalloproteinase 12 (MMP-12) has been described. The overexpression MMP-12 in myeloid lineage cells causes immune cell dysfunction resembling
Skeletal muscle (SM) is essential for movement, stability, and overall body function, it readily adapts to changes in energy demand. Myogenesis energy-intensive involves complex molecular cellular events. We recently demonstrated that the absence of lysosomal acid lipase (LAL) vivo significantly impacts SM phenotype, primarily by disrupting homeostasis reducing ATP production. As systemic LAL deficiency affects multiple organs, we hypothesized altered phenotype resulted from rather than...
In obesity, sustained adipose tissue (AT) inflammation constitutes a cellular memory that limits the effectiveness of weight loss interventions. Yet, its fasting regimen-dependent regulation is unknown. Here, we show cyclic intermittent (IF) exacerbates lipid-associated macrophage (LAM) inflammatory phenotype visceral AT in obese mice. Importantly, provide evidence this increase LAM abundance almost entirely dependent on p53-driven adipocyte apoptosis. Adipocyte-specific deletion p53...
Abstract In obesity, sustained adipose tissue (AT) inflammation constitutes a cellular memory that limits the effectiveness of weight loss interventions. Yet, impact fasting regimens on regulation AT immune infiltration is still elusive. Here, we show cyclic intermittent (IF) exacerbates lipid-associated macrophage (LAM) inflammatory phenotype visceral in obese mice. Importantly, this increase LAM abundance strongly p53 dependent and, at least part, mediated by p53-driven adipocyte...