A5075498676- Diabetes Management and Research
- Adipokines, Inflammation, and Metabolic Diseases
- Lysosomal Storage Disorders Research
- Pancreatic function and diabetes
- Botulinum Toxin and Related Neurological Disorders
- Sphingolipid Metabolism and Signaling
- SARS-CoV-2 and COVID-19 Research
- Blood Pressure and Hypertension Studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Adipose Tissue and Metabolism
- Immune cells in cancer
- Cultural Heritage Materials Analysis
- Neurological and metabolic disorders
- Long-Term Effects of COVID-19
- Autophagy in Disease and Therapy
- Calcium signaling and nucleotide metabolism
- Building materials and conservation
- Lipid metabolism and biosynthesis
- Muscle Physiology and Disorders
- Calpain Protease Function and Regulation
- COVID-19 and healthcare impacts
- Drug Solubulity and Delivery Systems
- Vaccine Coverage and Hesitancy
- Cellular transport and secretion
- Erythrocyte Function and Pathophysiology
Medical University of Graz
2023-2024
University of Parma
2024
University of Turin
2012-2023
Ospedale San Luigi Gonzaga
2023
Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
2021-2022
Advanced Micro Devices (Canada)
2022
IRCCS Ospedale San Raffaele
2021-2022
University of Campania "Luigi Vanvitelli"
2021-2022
Uppsala University
2021
The metabolic contribution of the small intestine (SI) is still unclear despite recent studies investigating involvement single cells in regional differences. Using untargeted proteomics, we identified characteristics three intestinal tracts C57BL/6J mice and found that proteins abundant mouse ileum correlated with high ileal expression corresponding genes humans. In SI mice, also detected an increasing abundance lysosomal acid lipase (LAL), which responsible for degrading triacylglycerols...
To date, the only enzyme known to be responsible for hydrolysis of cholesteryl esters and triacylglycerols in lysosome at acidic pH is lysosomal acid lipase (LAL). Lipid malabsorption small intestine (SI), accompanied by macrophage infiltration, one most common pathological features LAL deficiency. However, exact role intestinal lipid metabolism still unknown. We collected three parts SI (duodenum, jejunum, ileum) from mice with a global (LAL KO) or intestine-specific deletion (iLAL...
Abstract Background Matrix metalloproteinase 12 (MMP12) is a macrophage-secreted protein that massively upregulated as pro-inflammatory factor in metabolic and vascular tissues of mice humans suffering from cardiometabolic diseases (CMDs). However, the molecular mechanisms explaining contributions MMP12 to CMDs are still unclear. Methods We investigated impact deficiency on mouse model mimics human disease by simultaneously developing adipose tissue inflammation, insulin resistance,...
Abstract Background Activation of brown adipose tissue (BAT) has gained attention due to its ability dissipate energy and counteract cardiometabolic diseases (CMDs). Methods This study investigated the consequences cold exposure on BAT liver proteomes an established CMD mouse model based LDL receptor-deficient (LdlrKO) mice fed a high-fat, high-sucrose, high-cholesterol diet for 16 weeks. We analyzed metabolism in vivo performed untargeted proteomics LdlrKO maintained at 22 °C or 5 7 days....
Permeation across Caco-2 cells in lipolysis-permeation setups can predict the rank order of vivo drug exposure obtained with lipid-based formulations (LBFs). However, require a long differentiation period and do not capture all characteristics human small intestine. We therefore evaluated two vitro assays artificial lecithin-in-dodecane (LiDo) membranes MDCK as absorptive setup. Fenofibrate-loaded LBFs were used results from compared to literature plasma concentrations landrace pigs...
Abstract It is partially unknown whether the immune response to severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection persists with time. To address this issue, we detected presence of SARS-CoV-2 antibodies in different groups individuals previously diagnosed COVID-19 disease (group 1 and 2), or potentially exposed 3 4), a representative group limited environmental exposure virus due lockdown restrictions 5). The primary outcome was specific anti-SARS-CoV-2 assessed by...
Lysosomal acid lipase (LAL) is the only enzyme known to hydrolyze cholesteryl esters (CE) and triacylglycerols in lysosomes at an acidic pH. Despite importance of lysosomal hydrolysis skeletal muscle (SM), research this area limited. We hypothesized that LAL may play important role SM development, function, metabolism as a result lipid and/or carbohydrate disruptions. Mice with systemic deficiency (Lal-/-) had markedly lower mass, cross-sectional area, Feret diameter despite unchanged...
Lysosomal acid lipase (LAL) is the only known enzyme that degrades cholesteryl esters and triglycerides at an acidic pH. In LAL deficiency (LAL-D), dysregulated expression of matrix metalloproteinase 12 (MMP-12) has been described. The overexpression MMP-12 in myeloid lineage cells causes immune cell dysfunction resembling
Safety data regarding BNT162b2 in cancer patients (CPs) are scarce. Herein we report the side effects (SEs), adverse events (AEs), and patient-reported outcomes (PROs) following administration CPs treated at San Luigi Gonzaga University Hospital. All who agreed to participate our vaccination campaign received were included descriptive analysis. An anonymous questionnaire investigating occurrence of SEs/AEs PROs was administered study population 21 days after first dose. Pearson's chi-squared...