A5003112939- Occupational and environmental lung diseases
- Kidney Stones and Urolithiasis Treatments
- Climate Change and Health Impacts
- Chronic Kidney Disease and Diabetes
- Health, Environment, Cognitive Aging
- Air Quality and Health Impacts
- Therapeutic Uses of Natural Elements
- Heme Oxygenase-1 and Carbon Monoxide
- Heavy Metal Exposure and Toxicity
- Animal testing and alternatives
- Liver Disease Diagnosis and Treatment
- Spaceflight effects on biology
- Traumatic Brain Injury and Neurovascular Disturbances
- Alcohol Consumption and Health Effects
- Biomedical Research and Pathophysiology
- Energy and Environment Impacts
- Endoplasmic Reticulum Stress and Disease
- Pesticide Exposure and Toxicity
- Advanced Glycation End Products research
- Occupational exposure and asthma
- Carcinogens and Genotoxicity Assessment
- Barrier Structure and Function Studies
- Sugarcane Cultivation and Processing
- Biological Research and Disease Studies
University of Colorado Anschutz Medical Campus
2022-2025
University of Colorado Denver
2023
University of Montana
2022
Silica nanoparticles (SiNPs) released during the burning of sugarcane have been postulated to a role in chronic kidney disease unknown etiology. We tested hypothesis that pristine SiNPs size present might cause injury when administered through lung rats. 200- or 300-nm amorphous twice weekly (4 mg/dose), vehicle by oropharyngeal aspiration for 13 wk rats followed euthanasia after an additional (26 total). Tissues were evaluated presence and evidence histological injury. Both sizes caused...
IntroductionSugarcane workers are exposed to potentially hazardous agrochemicals, including pesticides, heavy metals, and silica. Such occupational exposures present health risks have been implicated in a high rate of kidney disease seen these workers.MethodsTo investigate potential biomarkers mechanisms that could explain chronic (CKD) among this worker population, paired urine samples were collected from sugarcane cutters at the beginning end harvest season Guatemala. Workers then...
Silica nanoparticles found in sugarcane ash have been postulated to be a toxicant contributing chronic kidney disease (CKD) of unknown etiology. However, although the administration manufactured silica is known cause tubulointerstitial rats, effect administering on pathology remains unknown. Here, we investigated whether can induce CKD rats. Sugarcane was administered for 13 wk into nares rats (5 mg/day 5 days/wk), and blood, urine, tissues were collected at (at end administration) separate...
Chronic kidney disease of unknown etiology (CKDu) is an epidemic which increasingly prevalent among agricultural workers and nearby communities, particularly those involved in the harvest sugarcane. While CKDu likely multifactorial, occupational exposure to silica nanoparticles (SiNPs), a major constituent within sugarcane ash, has gained increased attention as potential contributor. SiNPs have high for generation reactive oxygen species (ROS), their accumulation could result oxidative...
Article cKit Ligand (Stem Cell Factor)-Induced Immune Response via an Alternative Receptor in Human Cells Jihyung Hwang 1,†, Angela Reinert 2,†, Arthur Stem 2, Saerok Shim 1, Sinae Kim HeeJoon 3, Myungdal Yoon Seungheon Lee Donghwan Song Hyun Yoo Sunyoung Han 4, Mijeong Choi 5, Jared M. Brown 2,*, and Soohyun 1,3,* 1 Laboratory of Cytokine Immunology, Department Biomedical Science Technology, Konkuk University, Seoul 05029, Republic Korea 2 Pharmaceutical Sciences, Colorado Center for...
Blood Brain Barrier (BBB) breakdown is a secondary form of brain injury which has yet to be fully elucidated mechanistically. Existing research suggests that tight junction proteins between endothelial cells primary driver increased BBB permeability following injury, and intercellular signaling the neurovascular unit: cells, astrocytes, pericytes; contribute restoration. To expound upon this body research, we analyzed effects severely injured patient plasma on each cell types in monoculture...
Abstract We have hypothesized that sugarcane burning in developing countries contributes to an endemic kidney pathology agricultural workers called chronic disease of unknown etiology (CKDu). Elemental analysis shows stalks contain a high percentage amorphous silica (SiO2). Therefore, we generates nanoparticles (SiNPs) present inhalation hazard these workers. To determine if SiNPs are ash and biopsies from workers, utilized single particle inductively coupled plasma mass spectrometry found...
Abstract Multiple epidemics of chronic kidney disease an unknown etiology (CKDu), primarily in young healthy agricultural workers, have emerged communities around the world. We hypothesized that harvest and burning sugarcane leading to inhalation ash may contribute development CKDu. Sugarcane stalks consist ~80% amorphous silica we demonstrated following sugarcane, nano-sized particles (~200nm) are generated. To determine what effect such exposures on cells, a human proximal convoluted...