A5070527751- Chronic Kidney Disease and Diabetes
- Renal Diseases and Glomerulopathies
- COVID-19 Clinical Research Studies
- Dialysis and Renal Disease Management
- COVID-19 and healthcare impacts
- SARS-CoV-2 and COVID-19 Research
- Nephrotoxicity and Medicinal Plants
- Kidney Stones and Urolithiasis Treatments
- Renal and Vascular Pathologies
- Autopsy Techniques and Outcomes
- Renal Transplantation Outcomes and Treatments
- Climate Change and Health Impacts
- Thermoregulation and physiological responses
- Biomedical Research and Pathophysiology
- Healthcare cost, quality, practices
- Neurological and metabolic disorders
- Pancreatitis Pathology and Treatment
- Acute Kidney Injury Research
- Occupational and environmental lung diseases
- Systemic Sclerosis and Related Diseases
- Hemoglobinopathies and Related Disorders
- Renal and related cancers
- Vasculitis and related conditions
- Air Quality and Health Impacts
- Platelet Disorders and Treatments
Karolinska Institutet
2013-2025
Karolinska University Hospital
2021-2025
Integrated Cardio Metabolic Centre
2024
Canadian Society of Nephrology
2013
Mesoamerican nephropathy (MeN) is a chronic kidney disease affecting rural inhabitants in Central America. We have previously described the renal morphology 8 patients from El Salvador. To confirm pathology, we studied biopsies with MeN Nicaragua. Follow-up urine and blood samples both biopsy studies were collected to investigate natural history.Case series.In study, 19 male sugarcane workers Nicaragua suspected investigated questionnaires, biopsies, analysis. Inclusion criteria age 20 65...
Background: Chronic kidney disease of non-traditional origin (CKDnt) is common among Mesoamerican sugarcane workers. Recurrent heat stress and dehydration a leading hypothesis. Evidence indicate key role inflammation. Methods: Starting in sports pathophysiology literature, we develop theoretical framework how strenuous work could induce We describe the release pro-inflammatory substances from leaky gut and/or injured muscle, alone or combination with tubular fructose uric acid, aggravation...
ABSTRACT Background and hypothesis KDIGO recommends proteinuria <1 g/d as a treatment target in patients with immunoglobulin A nephropathy (IgAN) because of high risk progression to kidney failure. However, long-term outcomes low-grade remain insufficiently studied. Methods We enrolled biopsy-proven primary IgAN from the Swedish Renal Registry analyzed associations between urine albumin-to-creatinine ratio (uACR, categories <0.3, 0.3–0.5, 0.5–1.0, 1.0–1.5, 1.5–2.0, ≥2.0 g/g)...
In Sri Lanka, an endemic of chronic kidney disease unknown origin (CKDu) is affecting rural communities. The has similarities with Mesoamerican Nephropathy (MeN) in Central America, however it not yet been clarified if the endemics are related diagnostic entities. We designed this study biopsies from patients CKDu Lanka to compare MeN morphology. Eleven were recruited at General Hospital, Polonnaruwa, using similar inclusion and exclusion criteria as our previous studies. Inclusion 20–65...
Silica nanoparticles (SiNPs) released during the burning of sugarcane have been postulated to a role in chronic kidney disease unknown etiology. We tested hypothesis that pristine SiNPs size present might cause injury when administered through lung rats. 200- or 300-nm amorphous twice weekly (4 mg/dose), vehicle by oropharyngeal aspiration for 13 wk rats followed euthanasia after an additional (26 total). Tissues were evaluated presence and evidence histological injury. Both sizes caused...
Silica nanoparticles found in sugarcane ash have been postulated to be a toxicant contributing chronic kidney disease (CKD) of unknown etiology. However, although the administration manufactured silica is known cause tubulointerstitial rats, effect administering on pathology remains unknown. Here, we investigated whether can induce CKD rats. Sugarcane was administered for 13 wk into nares rats (5 mg/day 5 days/wk), and blood, urine, tissues were collected at (at end administration) separate...
Current knowledge about risk factors for severe COVID-19 among kidney transplant recipients stem from meta-analyses of small or regional studies. All in Sweden as 1 January 2020 (n = 5824) were followed during the first 2 years pandemic. Data Swedish Renal Registry and linked health care registries analyzed by multivariable adjusted logistic regression to identify COVID-19, defined hospitalization death due COVID-19. Male sex increased While many comorbidities associated with risk, their...
Abstract Background Although glomerular diseases are the third most frequent cause of end‐stage kidney disease worldwide, little is known about their long‐term outcomes. Methods In patients with chronic (CKD) stage 3–5 enrolled in Swedish Renal Registry, we compared risks hospitalization, replacement therapy (KRT), major cardiovascular events (MACE), and death four primary (IgA nephropathy [IgAN], focal segmental glomerulosclerosis [FSGS], minimal change [MCD], membranous [MN]), CKD due to...
ABSTRACT Background Patients on kidney replacement therapy (KRT) have been identified as a vulnerable group during the coronavirus disease 2019 (COVID-19) pandemic. This study reports outcomes of COVID-19 in KRT patients Sweden, country where were prioritized early vaccination campaign. Methods between January and December 2021 Swedish Renal Registry included. Data linked to national healthcare registries. The primary outcome was monthly all-cause mortality over 3 years follow-up. secondary...
ABSTRACT Background Several studies have demonstrated an increased risk of severe coronavirus disease 2019 (COVID-19) in chronic kidney (CKD) patients. However, few investigated the impact CKD stage and dialysis modality. The primary aim this study was to investigate association between stage, modality COVID-19. Secondly, we aimed comorbidities drugs on COVID-19 population. Methods This nationwide observational based data from Swedish Renal Registry three other national registries. Patients...
Serum creatinine (SCr) is a routine marker of kidney injury but also increases with dehydration and muscular work. This study was to elucidate whether increase in SCr associated more specific markers tubular interstitial function, during prolonged heat stress among workers at high risk chronic disease non-traditional origin (CKDnt).Urine monocyte chemoattractant protein-1 (MCP-1), molecule-1 (KIM-1), calbindin, glutathione S-transferase-π (GST-π), clusterin, interleukin 18 albumin,...
Abstract Background and Aims KDIGO recommends proteinuria <1 g/d as a treatment target in patients with immunoglobulin A nephropathy (IgAN) because of high-risk progression to kidney failure. However, long-term outcomes low-grade remain poorly studied. Method We enrolled biopsy-proven primary IgAN from the Swedish Renal Registry analyzed associations between first-recorded urinary albumin-to-creatinine ratio (uACR, categories <0.3, 0.3-0.5, 0.5-1.0, 1.0-1.5, 1.5-2.0 >2.0...
Chronic kidney disease of unknown cause (CKDu) is an emerging health problem in India and other countries worldwide. However, clinical descriptions, including pathology, are scarce.
Abstract Background and Aims Kidney transplant recipients (KTRs) are particularly susceptible to infections due their continuous immunosuppressive treatment, the presence of other comorbidities, and, in some cases, impaired kidney function. While previous research has identified certain risk factors for severe COVID-19 KTRs, comprehensive data at a national level—minimizing regional or center-specific influences—remains scarce. Our study aimed fill this gap by examining level. Thus, we...
Chronic kidney disease of unknown etiology (CKDu) is a progressive primary tubulointerstitial affecting persons in rural, agricultural communities worldwide. Some the other terms used to identify this include Mesoamerican nephropathy (MeN) Central America, Uddanam India, and chronic interstitial nephritis (CINAC). Well-described hotspots exist Sri Lanka, with investigations assess epidemiology cause(s) ongoing many regions world.1John O. Gummudi B. Jha A. et al.Chronic India: What do we know...
Mesoamerican nephropathy (MeN) is a chronic kidney disease affecting rural populations in Central America, especially sugarcane workers.1 Prospective studies and data regarding the natural history of are scarce. We have previously described morphology biochemical characteristics MeN 2 case series,2,3 including 1-to-2-year-long follow-up where mean estimated glomerular filtration rate (eGFR) decline was 4.4 mL/min/1.73 m2 per year.3 Another 2-year-long prospective study young men with...