A5047429701- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis and Reactivity of Heterocycles
- Molecular Sensors and Ion Detection
- Synthesis and Biological Evaluation
- Luminescence and Fluorescent Materials
- Ginkgo biloba and Cashew Applications
- Advanced biosensing and bioanalysis techniques
- Photochemistry and Electron Transfer Studies
- Synthesis and Reactions of Organic Compounds
- Metal complexes synthesis and properties
- Magnetism in coordination complexes
- Chemical Reaction Mechanisms
- Lanthanide and Transition Metal Complexes
- Porphyrin and Phthalocyanine Chemistry
- Multicomponent Synthesis of Heterocycles
- Selenium in Biological Systems
- Folate and B Vitamins Research
- Click Chemistry and Applications
- Cyclopropane Reaction Mechanisms
- Nanoplatforms for cancer theranostics
- Pharmacological Effects of Natural Compounds
- Free Radicals and Antioxidants
- Cyclization and Aryne Chemistry
- Photodynamic Therapy Research Studies
- Silymarin and Mushroom Poisoning
Ural State Medical University
2014-2024
Ural Federal University
2014-2024
Institute of Organic Synthesis
2022-2023
Ural Branch of the Russian Academy of Sciences
2023
Russian Academy of Sciences
2022
Pyrene-containing water-soluble probes for the fluorescent detection of nitroaromatic compounds (NACs), such as explosive components (2,4-DNT and 2,4,6-TNT) herbicides (2,4-dinitrocresol, 2,4-DNOC), in aqueous media are reported. In probes, introduction surface-active hydrophilic "heads" at periphery lipophilic (i.e., hydrophobic) pyrene "tails" resulted formation highly micelle-like aggregates/pre-associates solutions concentrations ≤10(-5) m. The enhanced fluorescence quenching herein...
Two new azaheterocycle-based bolas, such as (1-(4-(5-phenyl-1,3,4-oxadiazol-2-yl)phenyl)-1H-1,2,3-triazol-4-yl)-methylenyls α,ω-bisfunctionalized PEGs, were prepared via Cu-catalyzed click reaction between 2-(4-azidophenyl)-5-(aryl)-oxadiazole-1,3,4 and terminal ethynyls derived from PEG-3 PEG-4. Due to the presence of two heteroaromatic cores a PEG linker, these bola molecules are considered promising fluorescent chemosensors for electron-deficient species. As result well-pronounced...
Ginseng holds high medicinal and cosmetic value, with stem leaf extracts garnering attention for their abundant bioactive ingredients. Meanwhile, fermentation can enhance the effectiveness of cosmetics. The aim this study was to optimize ginseng produce functional were fermented five different strains lactic acid bacteria. Using 2,2-diphenyl-1-picrylhydrazyl (DPPH), hydroxyl radical (·OH), superoxide anion (O
A series of new indolyl- and pyrrolyl-substituted 2,2′-bipyridines were reported as push–pull fluorophores/probes by using a sequence the nucleophilic substitution reaction hydrogen (S N H) inverse-demand Diels–Alder reaction.
6-Fluoro-3-hydroxypyrazine-2-carboxamide (favipiravir) was one of the drugs recommended for treatment COVID-19. As with other drugs, issue disposal expired medicinal substances is relevant favipiravir. In present study we investigated a method possible chemical utiliza-tion favipiravir by its reaction arynes (1,2-dehydrobenzenes) to form isoquinolines, usable in practice.
1,4-Bis(5-phenyl-2-oxazolyl)benzene (POPOP) is a common scintillation fluorescent laser dye. In this manuscript, the synthesis of 2-Ar-5-(4-(4-Ar'-1H-1,2,3-triazol-1-yl)phenyl)-1,3,4-oxadiazoles (Ar, Ar' = Ph, naphtalenyl-2, pyrenyl-1, triphenilenyl-2), as PAH-based aza-analogues POPOP, by means Cu-catalyzed click reaction between 2-(4-azidophenyl)-5-Ar-1,3,4-oxadiazole and terminal ethynyl-substituted PAHs reported. An investigation photophysical properties obtained products was carried...
As the moistures were used phenyl-, 4'-aminophenil- and 4'-pyrydil radicals. Photophysical properties of 1,3,4-oxadiazoles are considered. Such recorded using three different solvent (acetonitrile, ethanol, water). Then titration by trifluoroacetic acid is carried out. The bigger change in UV-visible spectrum was observed for 4-aminophenyl-5-(pyridin-4-yl)-1,3,4-oxadiazole.
Linked to Alzheimer’s disease (AD), amyloids and tau-protein are known contain a large number of cysteine (Cys) residues. In addition, certain levels some common biogenic thiols (cysteine (Cys), homocysteine (Hcy), glutathione (GSH), etc.) in biological fluids closely related AD as well other diseases. Therefore, probes with selective interaction the above-mentioned can be used for monitoring visualizing changes (bio)thiols brain animal models disease. this study, new Eu(III), Tb(III),...
Abstract A convenient synthetic approach to 2-(2,2'-bipyridin-6-yl)-1,3,4-oxadiazole derivatives is proposed, which involves the preparation of 5-aryl-2,2'-bipyridine-6-carboxylic acid esters by “1,2,4-triazine” methodology and subsequent construction 1,3,4-oxadiazole ring via modification ester group.
The release rate of active pharmaceutical ingredients (APIs) from tablet dosage forms is significantly influenced by the composition formulation, in particular filler composition. In this work, we analyzed impact ratio excipients on vinpocetine a containing Ginkgo biloba L. extract as second API. Microcrystalline cellulose (MCC), hydroxypropylcellulose (L-HPC) mixed with MCC (up to 16% HPC), and partially pregelatinized starch were used different ratios excipients. Moreover, tween-80 was...
An effective approach to the synthesis of hybrid compounds, including fragments 5-aryl-2,2′-bipyridines and pyrene, which are potential interest from point view practical application, has been developed.
The article presents the results of a quantitative determination number flavonoids by spectrophotometry analysis in leaves Silybum marianum depending on level mineral nutrition. Also using HPLC-UV method, 2 flavones-apigenin and luteolin-were identified. As result, patterns accumulation from regime nutrition were revealed. maximum occurs when phosphorus potassium fertilizers are introduced into soil.
A POPOP analogue was synthesized using a progressive atom-economical click reaction with high yield. The resulting compound has similar photophysical properties compared to POPOP. emission bathochromic shift.