Laurent Fernando
A5054023660- Acute Myeloid Leukemia Research
- Histone Deacetylase Inhibitors Research
- Epigenetics and DNA Methylation
- Microbial Natural Products and Biosynthesis
- Chemical Synthesis and Analysis
- Computational Drug Discovery Methods
École Nationale Vétérinaire de Toulouse
2019-2021
Université de Toulouse
2019-2021
Université Toulouse III - Paul Sabatier
2019-2021
Toxalim Research Centre in Food Toxicology
2017-2019
European Bioinformatics Institute
2018
Mutations in IDH induce epigenetic and transcriptional reprogramming, differentiation bias, susceptibility to mitochondrial inhibitors cancer cells. Here, we first show that cell lines, PDXs, patients with acute myeloid leukemia (AML) harboring an mutation displayed enhanced oxidative metabolism. Along increase TCA cycle intermediates, this AML-specific metabolic behavior mechanistically occurred through the electron transport chain complex I activity, respiration, methylation-driven...
There are numerous applications that use the structures of protein-ligand complexes from PDB, such as 3D pharmacophore identification, virtual screening, and fragment-based drug design. The underlying these potentially much more informative if they contain biologically relevant bound ligands, with high similarity to cognate ligands. We present a study ligand-enzyme compares enabling best matches be identified. calculate molecular scores using method called PARITY (proportion atoms residing...
Isocitrate dehydrogenases (IDH) are involved in redox control and central metabolism. We hypothesized that key metabolic fluxes selectively reprogrammed to maintain biosynthetic homeostasis lower drug responses IDH mutant acute myeloid leukemia cells. Here we show reprogramming initiated by IDH1 mutation leads marked increases glucose, glutamine fatty acid catabolism along with enhancement of wild-type enzyme activity contribute provision α-KG required for 2-HG synthesis replenish Krebs...
Isocitrate dehydrogenases (IDH) are involved in redox control and central metabolism. Mutations IDH induce epigenetic transcriptional reprogramming, differentiation bias, BCL-2 dependence susceptibility to mitochondrial inhibitors cancer cells. Here we show that high sensitivity oxidative phosphorylation (OxPHOS) is due an enhanced metabolism cell lines, PDX patients with acute myeloid leukemia (AML) harboring mutation. Along increase TCA cycle intermediates, this AML-specific metabolic...