A5019019047- Muscle Physiology and Disorders
- Genomics and Chromatin Dynamics
- RNA Research and Splicing
- Epigenetics and DNA Methylation
- Acute Myeloid Leukemia Research
- Muscle activation and electromyography studies
- Histone Deacetylase Inhibitors Research
- Exercise and Physiological Responses
- Atherosclerosis and Cardiovascular Diseases
- Prosthetics and Rehabilitation Robotics
- Muscle metabolism and nutrition
- Cytokine Signaling Pathways and Interactions
- DNA Repair Mechanisms
- Systemic Lupus Erythematosus Research
- Chromosomal and Genetic Variations
- Neuroscience and Neural Engineering
- Ubiquitin and proteasome pathways
Inserm
2018-2025
Centre National de la Recherche Scientifique
2022-2025
Université Claude Bernard Lyon 1
2022-2025
Institut NeuroMyoGène
2021-2025
Hospices Civils de Lyon
2025
Hôpital Edouard Herriot
2025
Centre de Recherche en Cancérologie de Toulouse
2019-2021
Université de Toulouse
2019-2021
ideXlab (France)
2021
La Ligue Contre le Cancer
2021
Mutations in IDH induce epigenetic and transcriptional reprogramming, differentiation bias, susceptibility to mitochondrial inhibitors cancer cells. Here, we first show that cell lines, PDXs, patients with acute myeloid leukemia (AML) harboring an mutation displayed enhanced oxidative metabolism. Along increase TCA cycle intermediates, this AML-specific metabolic behavior mechanistically occurred through the electron transport chain complex I activity, respiration, methylation-driven...
Skeletal muscle is a plastic tissue that adapts to increased mechanical loading/contractile activity through fusion of stem cells (MuSCs) with myofibers, physiological process referred as myonuclear accretion. However, it still unclear whether accretion driven by loading per se, or occurs, at least in part, response injury/regeneration. Here, we developed non-damaging protocol evaluate contractile activity-induced accretion/hypertrophy conditions. Contractile was generated applying repeated...
Objective Inflammation drives cardiovascular disease in rheumatoid arthritis (RA). Treatment with tofacitinib, a JAK1/JAK3 inhibitor, is associated increased events patients RA. Here, we determined its effects on cytokine production during interactions between immune cells at the synovial and vascular levels impact endothelial activation coagulation inflammation. Methods Activated human peripheral blood mononuclear (PBMCs) were cocultured RA synoviocytes or (ECs) mimicking cellular synovium...
Abstract Skeletal muscle is a plastic tissue that adapts to exercise through fusion of stem cells (MuSCs) with myofibers, physiological process referred as myonuclear accretion. However, it still unclear whether accretion driven by increased mechanical loading per se , or occurs, at least in part, response exercise-induced injury. Here, we developed carefully monitored and individualized neuromuscular electrical stimulation (NMES) training protocol the mouse plantar flexor muscles. Each NMES...
Abstract Chromatin organization is essential for appropriate interpretation of the genetic information. Here, we demonstrated that chromatin associated proteins HP1 are dispensable cell survival but within hepatocytes to prevent liver tumor development. Molecular characterization pre-malignant HP1-Triple KO livers revealed maintenance structural heterochromatin surprisingly, not several well known functions such as genome stability nor regulation major satellite repeat expression liver. We...
Isocitrate dehydrogenases (IDH) are involved in redox control and central metabolism. Mutations IDH induce epigenetic transcriptional reprogramming, differentiation bias, BCL-2 dependence susceptibility to mitochondrial inhibitors cancer cells. Here we show that high sensitivity oxidative phosphorylation (OxPHOS) is due an enhanced metabolism cell lines, PDX patients with acute myeloid leukemia (AML) harboring mutation. Along increase TCA cycle intermediates, this AML-specific metabolic...