A5103214456- Bone health and osteoporosis research
- Inflammatory Bowel Disease
- Microscopic Colitis
- Nutrition and Health in Aging
- Bone Metabolism and Diseases
- Spine and Intervertebral Disc Pathology
- Birth, Development, and Health
- Bone and Joint Diseases
- Vitamin D Research Studies
- Radiomics and Machine Learning in Medical Imaging
- Glioma Diagnosis and Treatment
- Orthopaedic implants and arthroplasty
- Body Composition Measurement Techniques
- Hemoglobinopathies and Related Disorders
- Pancreatic and Hepatic Oncology Research
- Hip and Femur Fractures
- Medical Imaging Techniques and Applications
- Trace Elements in Health
- Hormonal and reproductive studies
- Brain Metastases and Treatment
- Liver Disease Diagnosis and Treatment
- Rheumatoid Arthritis Research and Therapies
- Radiation Dose and Imaging
- Advanced Radiotherapy Techniques
- Management of metastatic bone disease
Royal Adelaide Hospital
2006-2020
Eastern Health
2014
Monash University
2014
Monash Health
2014
Kantonsspital St. Gallen
2013
University of St. Gallen
2011
University of South Australia
2006
The University of Adelaide
2005
University Medical Center
2003
Thomas Jefferson University
2003
This phase III randomized trial evaluated survival as well neurologic and neurocognitive function in patients with brain metastases from solid tumors receiving whole-brain radiation therapy (WBRT) or without motexafin gadolinium (MGd).Patients were randomly assigned to 30 Gy of WBRT +/- 5 mg/kg/d MGd. Survival time progression determined by a blinded events review committee (ERC) coprimary end points. Standardized investigator assessment testing evaluated.Four hundred one (251 non-small-cell...
<h2>Abstract</h2> Purpose: To determine the maximum acutely tolerable dose of single fraction radiosurgery in patients with recurrent previously irradiated primary brain tumors or metastases. Methods and Materials: Between August 1990 September 1993, 102 analyzable were entered on Radiation Therapy Oncology Group (RTOG) protocol 90-05, 38 whom had (median prior 60 Gy), 64 metastases 30 Gy) ≤ 40 mm diameter. Unacceptable toxicity was defined as irreversible Grade 3, any 4, 5 central nervous...
Summary Background Body composition is poorly studied in inflammatory bowel disease ( IBD ). Sarcopenia describes a loss of muscle mass and strength. Aim To assess the prevalence low lean LM ), sarcopenia associated morbidity an adult cohort. Methods Cross‐sectional data were gathered on pre‐menopausal 18‐ to 50‐year‐old patients with . Whole‐body dual‐energy X ‐ray absorptiometry, anthropometric assessment grip strength performed. Low was defined as ≥1 s.d. below population mean for...
This study compared the traditional two-compartment (fat mass or FM; fat free FFM) hydrodensitometric method of body composition measurement, which is based on density, with three (FM, total water TBW, dry mass)- and four bone mineral BMM, residual)-compartment models in highly trained men ( n = 12), sedentary women 12). The means variances for relative (%BF) differences between two- three-compartment [2.2 ± 1.6 (SD) % BF; 48] were significantly greater P ≤ 0.02) than those three-...
Rising rates of obesity have been reported in patients with inflammatory bowel disease (IBD); however, prospective data is lacking. The aim this study to prospectively evaluate body composition adults IBD over 24 months.Whole dual energy X-ray absorptiometry (DXA) was performed at 0 months, 12 and months. Bone mineral density (BMD), fat mass index (FMI (kg)/height (m²)), appendicular skeletal muscle (ASMI visceral adipose tissue the height (VHI, VAT area (cm³)/height clinical anthropometric...
The tempo and change in bone growth during puberty relation to physical is described a cohort of 56 boys 52 girls. Distal forearm width, mineral content volumetric density, anthropometry pubertal status were measured at ages 11, 13, 15 17 y, age y. Bone width increased independently with for each stage. Volumetric density fell early then rapidly. Maximal increase all variables occurred earlier girls than earliest content, density. In most the 12 mo before after menarche. degree tracking was...
Visceral adipose tissue (VAT) has been proposed to play a pathogenic role in Crohn's disease (CD); however, prospective clinical data are lacking. The aim was evaluate whether VAT, beyond body mass index (BMI), is associated with CD behavior, activity, quality of life (QoL), or outcomes. Body composition and clinical, anthropometric, activity (fecal calprotectin [FC]), QoL scores were gathered prospectively on adults at 0, 12, 24 months. BMI and, VAT metrics (visceral volume [cm3]/height...
Intrauterine growth restriction (IUGR) increases the risk of adult type 2 diabetes (T2D) and obesity. Neonatal exendin-4 treatment can prevent in IUGR rat, but whether this will be effective a species where pancreas is more mature at birth unknown. Therefore, we evaluated effects neonatal administration after experimental placental fetal on metabolic outcomes sheep. Body composition, glucose tolerance, insulin secretion sensitivity were assessed singleton-born sheep from control (CON; n = 6...
We describe a prospective study in which bone mineral density (BMD) was measured total body and regions, proximal femur, lumbar spine, forearm 84 apparently normal postmenopausal women with spinal radiographs 47 1-10 wedged or compressed vertebrae. There history of peripheral fracture 35 the controls 30 osteoporotics (p < 0.02) but there no association between vertebral wrist fracture. At all sites differences BMD "normal"and "osteoporotic" highly significant "ribs" "arms" remained after...
The influences on bone growth of familial factors, nutrition and physical activity are described in a cohort 108 children (56M, 52F). Distal forearm width, mineral content volumetric density, anthropometry, pubertal status, nutritional intake were measured at ages 11, 13, 15 17 y. Parental status was also determined. Both mothers' fathers' variables significant predictors the respective children's variables, but heritability estimates greater between mothers their than fathers children. By...
The earliest radiological change in rheumatoid arthritis (RA) is periarticular osteopenia, which occurs prior to the appearance of erosions and clinically apparent deformities. aim study was measure bone mineral density (BMD) hands patients with early RA, using dual energy X-ray absorptiomentry (DEXA) correlate this markers disease activity progression.The population (n = 50) RA < 3 years duration underwent measurement BMD non-dominant hand, femoral neck lumbar spine clinical assessment at...
Despite better disease suppression with combination disease-modifying antirheumatic drugs (DMARDs), some patients rheumatoid arthritis (RA) have progressive erosive disease. The objective of this study was to determine whether hand bone mineral density (BMD) loss in the first 6 months treatment indicates increased risk erosions at 12 months.Patients DMARD-naive early RA receiving treat-to-target therapy were studied (n = 106). Hand BMD measured baseline and by dual x-ray absorptiometry. feet...
Anthropometric profiles together with a 4 compartment criterion model of body composition analysis (total water, bone mineral, fat and residual masses via combination deuterium dilution, dual-energy x-ray absorptiometry hydrodensitometry) were conducted on 3 elite male bodybuilders 10 wk then 5 d before competition. A mean mass reduction from 99.70 (Quetelet's Index = 31.6 kg/m2) to 92.79 kg 29.2 was accompanied by decline in the sum 8 skinfold thicknesses (triceps, subscapular, biceps,...
The failure of orthopedic implants in osteoporotic patients is attributed to the lack sufficient bone stock and regenerative capacity but most treatments for osteoporosis fail address this issue. rhBMP-2 known promote formation under normal conditions has not been used clinically condition. Osteoporosis was induced 19 ewes using ovariectomy, low calcium diet, steroid injection. After induction, withdrawn pellets containing inert carrier with either slow or fast-release formulation were...