A5010981769- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
- Adrenal Hormones and Disorders
- Vasculitis and related conditions
- Renaissance and Early Modern Studies
- Autoimmune and Inflammatory Disorders Research
- Renal Diseases and Glomerulopathies
- Hepatitis C virus research
- Historical and Cultural Archaeology Studies
- Patient Satisfaction in Healthcare
- Peripheral Neuropathies and Disorders
- Healthcare Systems and Technology
- Spondyloarthritis Studies and Treatments
- Reformation and Early Modern Christianity
- Ocular Diseases and Behçet’s Syndrome
- Renaissance Literature and Culture
- Monoclonal and Polyclonal Antibodies Research
- Biosimilars and Bioanalytical Methods
- Otitis Media and Relapsing Polychondritis
- Microscopic Colitis
- Delphi Technique in Research
- Patient-Provider Communication in Healthcare
- Atherosclerosis and Cardiovascular Diseases
- Vaccine Coverage and Hesitancy
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
Queen Elizabeth Hospital
2012-2025
The University of Adelaide
2015-2025
Royal Adelaide Hospital
2013-2025
Central Adelaide Local Health Network
2023-2025
Basil Hetzel Institute
2015-2025
The University of Sydney
2023
Rheumatology Consultants
2023
Royal North Shore Hospital
2023
Queen Elizabeth Hospital
2021-2023
Center for Rheumatology
2023
To determine long-term (20 year) survival in RA patients enrolled the Australian Rheumatology Association Database (ARAD).ARAD with and data linkage consent who were diagnosed from 1995 onwards included. Death obtained through to National Index. Results compared age-, gender- calendar year-matched population mortality rates. Analysis included both standardized ratio (SMR) relative models. Restricted mean time (RMST) at 20 years was calculated as a measure of life lost. Cause-specific SMRs...
Abstract Background/Aim To determine the epidemiology and clinical features of biopsy‐proven giant cell arteritis ( GCA ) in South A ustralia SA ). Methods Patients with were identified from pathology reports temporal artery biopsies at P athology laboratories, 1 J anuary 1992, to 31 uly 2011. Epidemiological data collected through patient questionnaires standardised case note reviews. Incidence was estimated using ustralian B ureau S tatistics population for . Seasonality analysed by...
Glucocorticoids (GCs) are used in ~ 60% of patients with rheumatoid arthritis (RA). Although disease-modifying, they also have significant adverse effects. Understanding factors associated GC use may help minimise exposure. The aims the present study were to describe oral RA; determine any change over time; and use, commencement or cessation.Adult RA identified Australian Rheumatology Association Database (ARAD), a national registry that collects long-term outcome data from inflammatory...
Objective. To inform development of a core domain set for outcome measures clinical trials in polymyalgia rheumatica (PMR), we conducted patient consultations, systematic review, Delphi study, and 2 qualitative studies. Methods. Domains identified by 70% or more physicians and/or patients the study were selected. The conceptual framework derived from research studies helped meaning each its relationship to others. draft was refined further discussion with who had participated study. At...
Background: Patients with rheumatoid arthritis (RA) have shared care between rheumatologists and general practitioners (GPs).Rheumatologists guide immunosuppressive therapy, whilst GPs rely on analgesia glucocorticoid (GC) therapy to manage active disease.The objective of this study was describe patterns GC prescribing for patients RA in primary determine the influence patient characteristics prescriber.Methods: Incident were identified within Clinical Practice Research Datalink, a United...
The aim of this study was to explore, from the patient's perspective, beneficial and adverse effects (AEs) glucocorticoids (GCs) in patients with rheumatic diseases, be used development a patient-reported outcome measure.A cross-sectional survey, capturing benefits AEs GC use, administered 2 groups patients: (1) those attending tertiary rheumatology clinic various diseases who had GCs within past year (2) Hospital for Special Surgery rheumatoid arthritis database.Cohort 1 55 users, cohort 95...
Abstract Aim The exact diagnostic role of temporal artery ultrasound ( TAU ) remains unclear. aim this study was to determine the sensitivity and specificity a positive halo sign in patients undergoing clinical setting, perform review existing evidence. Method Patients who had undergone at single centre Australia were included study. presence or absence whether it unilateral bilateral determined retrospectively from radiology reports. Pathology results used which underwent biopsy if...
The need for a standardized instrument to measure the effect of glucocorticoid (GC) therapy has been well documented in literature. aim first GC Special Interest Group was define research agenda around development patient-reported outcome (PROM) this area.The results background literature search and preliminary pilot survey 2 qualitative studies were presented facilitate agenda.It agreed that there data-driven PROM identified both positive negative effects be used across all inflammatory...
Objective Prednisolone is an effective oral glucocorticoid for managing symptoms of rheumatoid arthritis (RA) but has predictable and common adverse effects. We explored patient perspectives prednisolone use in RA. Methods Patients with RA registered the Australian Rheumatology Association Database (ARAD) who had completed ARAD questionnaire preceding 12 months were invited to participate online survey. Responses linked already collected respondent demographics, medication use,...
Abstract Objectives To evaluate the reliability and validity of an adapted Commissioning for Quality in Rheumatoid Arthritis-RA-Patient-Reported Experience Measure (CQRA-RA-PREM) assessing care experience Australian rheumatology outpatient cohort. Methods Individual patient interviews were performed to check language completion time CQRA-RA-PREM before modification. Rheumatology Association Database (ARAD) participants completed CQRA-PREM-Australian version (CQRA-PREM-AU) (22 items, 5...
In 1563 the Council of Trent ordered all dioceses to establish seminaries for training secular clergy, but this attempt improve education, competence and discipline priests was flawed: Council's failure provide or identify resources pay new institutions meant that many could not (or would not) support themselves. Moreover, were required attend seminaries, so alternative paths ordination (including traditional apprentice system placing aspirants under care direction a qualified priest)...
Despite better disease suppression with combination disease-modifying antirheumatic drugs (DMARDs), some patients rheumatoid arthritis (RA) have progressive erosive disease. The objective of this study was to determine whether hand bone mineral density (BMD) loss in the first 6 months treatment indicates increased risk erosions at 12 months.Patients DMARD-naive early RA receiving treat-to-target therapy were studied (n = 106). Hand BMD measured baseline and by dual x-ray absorptiometry. feet...
Abstract Objectives Glucocorticoids (GCs) (‘steroids’) are used to treat rheumatic diseases but adverse effects common. We aimed explore the impact of GC therapy on health-related quality life (HRQoL), inform development a treatment-specific patient-reported outcome measure (PROM) for use in clinical trials and practice. Methods Semi-structured qualitative interviews were conducted with patients from UK, USA Australia, treated condition GCs last 2 years. Purposive sampling was select...
To determine distinct trajectories of self-reported pain-related health status in rheumatoid arthritis (RA), their relationship with sociodemographic factors and medication use. 988 Australian Rheumatology Association Database participants RA (71% female, mean age 54 years, disease duration 2.3 years) were included. Distinct multi-trajectories over 15-year follow-up for five different outcome measures (Health Assessment Questionnaire Disability Index, visual analogue scores pain, arthritis,...
Giant cell arteritis (GCA) is one of the commonest forms vasculitis in elderly, and may result blindness stroke. The pathogenesis GCA not understood, although environmental, infectious genetic risk factors are implicated. One gene interest PTPN22 , encoding lymphoid protein tyrosine phosphatase (Lyp), expressed exclusively immune cells, which proposed to be an ‘archetypal non-HLA autoimmunity gene’. minor allele a functional single nucleotide polymorphism (rs2476601, R620W), disrupts...
To determine patient experiences of glucocorticoid (GC) therapy in polymyalgia rheumatica (PMR) and giant cell arteritis (GCA).Patients with a diagnosis PMR or GCA were invited to participate this qualitative study that used focus groups explore: symptoms onset, process diagnosis, treatment, adverse effects (AEs), ongoing condition/s management. Data transcribed verbatim "framework" approach was for analysis interpretation.Fourteen patients participated. Weight gain, changes face neck shape,...