A5076926043- Rheumatoid Arthritis Research and Therapies
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Autoimmune and Inflammatory Disorders Research
- Systemic Sclerosis and Related Diseases
- Adrenal Hormones and Disorders
- Systemic Lupus Erythematosus Research
- Lymphoma Diagnosis and Treatment
- Childhood Cancer Survivors' Quality of Life
- Microscopic Colitis
- Clinical Reasoning and Diagnostic Skills
- Dermatology and Skin Diseases
- Vascular Procedures and Complications
- Cardiac, Anesthesia and Surgical Outcomes
- Asthma and respiratory diseases
- Psoriasis: Treatment and Pathogenesis
- Diabetes Management and Education
- Aortic aneurysm repair treatments
- Celiac Disease Research and Management
University of the West of England
2021-2025
University Hospitals Bristol NHS Foundation Trust
2021-2025
University Hospitals Bristol and Weston NHS Foundation Trust
2021-2025
Center for Rheumatology
2023
Bristol Royal Infirmary
2021-2022
St Richard's Hospital
2002
Abstract Background Screening for abdominal aortic aneurysm (AAA) is commonly restricted to men. Recent studies have indicated a possible increase in deaths due ruptured AAA women, and higher rate of rupture women than The present report details results from randomized controlled trial that assessed the effects screening AAA. Methods Some 9342 aged 65–80 years were entered into age-matched screen control groups. A single ultrasonographic scan was offered arm study. Women with an received...
Objectives The Steroid PRO is a treatment-specific patient-reported outcome questionnaire which measures the impact of glucocorticoids on health-related quality life. It has 15 items grouped into 4 domains (Social impact, Impact Appearance, Psychological and Treatment Concerns). Initially developed validated in rheumatic diseases, demonstrates potential for broader application patients with other inflammatory conditions. objective this study was to assess face validity, content validity...
To explore patients' perspectives on the impact of appearance changes attributed to glucocorticoid treatment. We conducted a secondary inductive thematic analysis 'Steroid PRO' semi-structured interviews with patients rheumatic conditions receiving glucocorticoids in UK, USA, and Australia. Sixty patient were analysed. Age 26-84 years; 39 (65%) females, with: systemic vasculitis (n = 19), inflammatory arthritis 14), crystal arthropathy 2), connective tissue disorders 16), other/multiple 9)....
Abstract Objectives Glucocorticoids (GCs) (‘steroids’) are used to treat rheumatic diseases but adverse effects common. We aimed explore the impact of GC therapy on health-related quality life (HRQoL), inform development a treatment-specific patient-reported outcome measure (PROM) for use in clinical trials and practice. Methods Semi-structured qualitative interviews were conducted with patients from UK, USA Australia, treated condition GCs last 2 years. Purposive sampling was select...
Objectives Glucocorticoids used in the treatment of inflammatory rheumatic conditions can impact on health-related quality life. An underpinning qualitative study developed a long-list candidate items for treatment-specific patient-reported outcome (PRO) measure. The objective this paper is to determine scale structure and psychometric properties Steroid PRO. Methods A cross-sectional survey adults from UK, USA, Australia New Zealand, taking glucocorticoids disease. Initial collected...
The Outcome Measures in Rheumatology (OMERACT) Glucocorticoid (GC) Impact Working Group has been working to develop a core domain set measure the impact of GCs on patients living with rheumatic and musculoskeletal diseases. mandatory domains previously identified for inclusion all clinical trials measuring GC effects include infection, bone fragility, mood disturbance, hypertension, diabetes, weight, fatigue, mortality. Before progressing instrument selection, sought establish precise...
Abstract Background/Aims To explore patients’ perspectives on the impact of appearance changes attributed to glucocorticoid treatment. Methods We conducted a secondary analysis semi-structured interviews with patients rheumatic conditions receiving glucocorticoids in UK, USA, and Australia. Interview data were analysed inductively develop preliminary individual overarching themes. Results 60 patient analysed. Patients ranged from 26-84 years, 39 (65%) female. had diagnoses systemic...
Abstract Background/Aims Glucocorticoids (GCs) used in the treatment of inflammatory rheumatic conditions can impact on patients different ways. The objective this study was to identify socio-demographic and clinical factors associated with health-related quality life (HRQoL) undertaking GCs for a disease. Methods This cross-sectional using online survey methods. Participants taking disease from Australia, United Kingdom States America were included. HRQoL measured EQ-5D-5L converted into...
Background: Glucocorticoids (GCs) are a key treatment for the autoimmune rheumatic diseases; however, they produce numerous physical and psychological side effects. 1 The Outcome Measures in Rheumatology (OMERACT) Glucocorticoid Working Group have identified that there no Patient Reported (PROMs) assessing impact of systemic GC therapy across multiple diseases from patient’s perspective. 2,3 Objectives: aim is to explore GCs on symptoms health-related quality life adults with inflammatory...
Objectives Patients with inflammatory arthritis report that fatigue is challenging to manage. We developed a manualised, one-to-one, cognitive–behavioural intervention, delivered by rheumatology health professionals (RHPs). The Fatigue - Reducing its Effects through individualised support Episodes in Inflammatory Arthritis (FREE-IA) study tested the feasibility of RHP training, intervention delivery and outcome collection ahead potential trial clinical cost-effectiveness. Methods In this...
We developed a brief cognitive behavioural, one-to-one intervention to reduce fatigue impact for patients with inflammatory arthritis. This qualitative process evaluation explored acceptability and potential refinements from the perspective of who attended sessions rheumatology health professionals (RHPs) delivered intervention.Interviews were conducted RHPs five National Health Service (NHS) sites. Data analysed using inductive thematic analysis.Twenty-two 11 participated.Collaborative,...
Abstract Background/Aims Patients with inflammatory arthritis report that fatigue can be a challenging symptom to manage, little support available. In response, we developed brief one-to-one cognitive-behavioural manualised intervention, delivered by rheumatology health professionals (RHPs), help patients manage their fatigue. Methods We designed single-arm feasibility study called FREE-IA (Fatigue - Reducing its Effects through individualised Episodes in Inflammatory Arthritis). were...
Abstract Background/Aims Systemic glucocorticoids are key in the management of life- and organ-threatening rheumatic diseases, but have wide-ranging adverse effects concern to patients clinicians. We aimed validate a Patient Reported Outcome (PRO) measure (the Steroid PRO) for assessing impact on health-related quality life (HRQoL) receiving disease. Methods This was cross-sectional study adults from UK, USA, Australia New Zealand, taking An online survey conducted at two time points: Time...
Abstract Background/Aims Glucocorticoids (GCs) are widely used to treat inflammatory rheumatic diseases. GCs carry a range of adverse effects concern patients and clinicians. The objective this study was explore the impact GC therapy on health-related quality life (HRQoL) during treatment for diseases, as basis development patient-reported outcome measure (PROM) be in clinical trials practice. Methods Patients from UK, USA Australia who were treated with last two years condition invited take...
Abstract Background/Aims Patients with inflammatory arthritis report fatigue as a primary symptom that affects everyday life. FREE-IA (Fatigue - Reducing its Effects through individualised support Episodes in Inflammatory Arthritis) is feasibility study of brief intervention (2-4 sessions 20-30 minutes) designed to reduce impact. The patients and health professionals delivered by rheumatology practitioners one-to-one sessions, after training using manual. aim this process evaluation was...