A5079330958- Pregnancy and preeclampsia studies
- Gestational Diabetes Research and Management
- Meta-analysis and systematic reviews
- Statistical Methods in Clinical Trials
- Air Quality and Health Impacts
- Birth, Development, and Health
- Advanced Causal Inference Techniques
- Noise Effects and Management
- Climate Change and Health Impacts
- Health Systems, Economic Evaluations, Quality of Life
- Endometriosis Research and Treatment
- Statistical Methods in Epidemiology
- Epilepsy research and treatment
- HIV/AIDS Research and Interventions
- Bariatric Surgery and Outcomes
- Obesity, Physical Activity, Diet
- Maternal and fetal healthcare
- Pharmacological Effects and Toxicity Studies
- Statistical Methods and Bayesian Inference
- Musculoskeletal pain and rehabilitation
- Preterm Birth and Chorioamnionitis
- Diet, Metabolism, and Disease
- HIV, Drug Use, Sexual Risk
- Adolescent and Pediatric Healthcare
- Gynecological conditions and treatments
Queen Mary University of London
2013-2023
Asthma UK
2015-2018
Barts Health NHS Trust
2018
Precision medicine research often searches for treatment‐covariate interactions, which refers to when a treatment effect (eg, measured as mean difference, odds ratio, hazard ratio) changes across values of participant‐level covariate age, gender, biomarker). Single trials do not usually have sufficient power detect genuine motivate the sharing individual participant data (IPD) from multiple meta‐analysis. Here, we provide statistical recommendations conducting and planning an IPD...
Low emission zones (LEZ) are an increasingly common, but unevaluated, intervention aimed at improving urban air quality and public health. We investigated the impact of London's LEZ on children's respiratory health.We did a sequential annual cross-sectional study 2164 children aged 8-9 years attending primary schools between 2009-10 2013-14 in central London, UK, following introduction February, 2008. examined association modelled pollutant exposures nitrogen oxides (including dioxide [NO2])...
Unexpected clinical deterioration before 34 weeks gestation is an undesired course in early-onset pre-eclampsia. To safely prolong preterm gestation, accurate and timely prediction of complications required. Women with confirmed early onset pre-eclampsia were recruited from 53 maternity units the UK to a large prospective cohort study (PREP-946) for development prognostic models overall risk experiencing complication using logistic regression (PREP-L), predicting time adverse maternal...
Background Pregnant women with epilepsy on antiepileptic drugs (AEDs) may experience a reduction in serum AED levels. This has the potential to worsen seizure control. Objective To determine if, pregnant AEDs, additional therapeutic drug monitoring reduces deterioration compared clinical features after Design A double-blind, randomised trial nested within cohort study was conducted and qualitative of acceptability two strategies undertaken. Stratified block randomisation 1 : allocation...
<h3>ABSTRACT</h3> Homeless people have complex problems. GP enhanced care (Pathway) has shown benefits. We performed a randomised, parallel arm trial at two large inner city hospitals. Inpatient homeless adults were randomly allocated to either standard (all management by the hospital-based clinical team) or with input from team. The hospital data system provided healthcare usage information, and we used questionnaires assess quality of life. 206 patients 204 usual care. Length stay (up 90...
The adverse effects of traffic-related air pollution on children's respiratory health have been widely reported, but few studies evaluated the impact traffic-control policies designed to reduce urban pollution. We assessed associations between pollutants and respiratory/allergic symptoms amongst 8–9 year-old schoolchildren living within London Low Emission Zone (LEZ). Information was obtained using a parent-completed questionnaire linked modelled annual pollutant concentrations based...
Background The prognosis of early-onset pre-eclampsia (before 34 weeks’ gestation) is variable. Accurate prediction complications required to plan appropriate management in high-risk women. Objective To develop and validate models for outcomes pre-eclampsia. Design Prospective cohort model development, with validation two external data sets. Setting Model development: 53 obstetric units the UK. transportability: PIERS (Pre-eclampsia Integrated Estimate RiSk mothers) PETRA (Pre-Eclampsia...
Obstetrics focuses on the early identification of pregnancies at risk adverse outcomes to plan targeted intervention. Clinicians often use probabilistic reasoning, intuitively based clinical history and tests, assess complications in a mother or fetus; however, they need be aware false-positive false-negative test results their decision-making. Prediction models (also known as prognostic models) provide individualised estimates for clinically important patients with particular disease...
Meta-analysis based on individual participant data (IPD), often described as the 'gold standard' for effectiveness evidence synthesis, is increasingly being deployed despite more resource intensive than collating study-level results. Its professed virtues include ability to incorporate unreported and standardise variables their definitions across trials. In reality, data, although present in shared datasets, might still not be usable analysis. The characteristics of trial participants...
Laparoscopic ventral mesh rectopexy (LVMR) is an established treatment for external full-thickness rectal prolapse. However, its clinical efficacy in patients with internal prolapse uncertain due to the lack of high-quality evidence.An individual level, stepped-wedge randomised trial has been designed allow observer-blinded data comparisons between awaiting LVMR those who have undergone surgery. Adults symptomatic prolapse, unresponsive prior conservative management, will be eligible...
Early-onset pre-eclampsia with raised blood pressure and protein in the urine before 34 weeks' gestation is one of leading causes maternal deaths UK. The benefits to child from prolonging pregnancy need be balanced against risk deterioration. Accurate prediction models risks are needed plan management. We aim undertake a multicentre prospective cohort study (Prediction Risks Early onset Pre-eclampsia (PREP)) develop clinical women early-onset pre-eclampsia, for adverse outcomes by 48 h...
Background Endometriosis is a chronic inflammatory condition affecting 6%-10% of women reproductive age and defined by the presence endometrial-like tissue outside uterus (lesions), commonly pelvis ovaries. It associated with debilitating pelvic pain, infertility, fatigue often has devastating effects on quality life (QoL). Although it as common back poorly understood, treatment diagnosis are delayed, leading to unnecessary suffering. no cure. Surgery one several management options....