A5025190875- Cardiac, Anesthesia and Surgical Outcomes
- Pelvic floor disorders treatments
- Gastrointestinal motility and disorders
- Anorectal Disease Treatments and Outcomes
- Genetic factors in colorectal cancer
- Acute Kidney Injury Research
- Hernia repair and management
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Colorectal Cancer Screening and Detection
- COVID-19 and healthcare impacts
- Colorectal Cancer Treatments and Studies
- Delphi Technique in Research
- Eating Disorders and Behaviors
- Research in Social Sciences
- Congenital gastrointestinal and neural anomalies
- Enhanced Recovery After Surgery
- Pancreatic and Hepatic Oncology Research
- Cancer Genomics and Diagnostics
- Minimally Invasive Surgical Techniques
- Respiratory Support and Mechanisms
- Education, Psychology, and Social Research
- Complementary and Alternative Medicine Studies
- Respiratory and Cough-Related Research
- Cancer Cells and Metastasis
- Ultrasound in Clinical Applications
Royal Shrewsbury Hospital
2014-2023
Shrewsbury and Telford Hospital NHS Trust
2021-2023
Heart of England NHS Foundation Trust
2008
Background Chronic constipation affects 1–2% of adults and significantly quality life. Beyond the use laxatives other basic measures, there is uncertainty about management, including value specialist investigations, equipment-intensive therapies using biofeedback, transanal irrigation surgery. Objectives (1) To determine whether or not standardised specialist-led habit training plus pelvic floor retraining computer-assisted direct visual biofeedback more clinically effective than alone,...
Laparoscopic ventral mesh rectopexy (LVMR) is an established treatment for external full-thickness rectal prolapse. However, its clinical efficacy in patients with internal prolapse uncertain due to the lack of high-quality evidence.An individual level, stepped-wedge randomised trial has been designed allow observer-blinded data comparisons between awaiting LVMR those who have undergone surgery. Adults symptomatic prolapse, unresponsive prior conservative management, will be eligible...
Abstract Background The effectiveness of laparoscopic ventral mesh rectopexy (LVMR) in patients with defecatory disorders secondary to internal rectal prolapse is poorly evidenced. A UK-based multicenter randomized controlled trial was designed determine the clinical efficacy LVMR compared controls at medium-term follow-up. Methods conducted from March 1, 2015 TO January 31, 2019. stepped-wedge RCT design permitted observer-masked data comparisons between awaiting (controls) those who had...
The aim was to determine whether specialist-led habit training using Habit Training with Biofeedback (HTBF) is more effective than alone (HT) for chronic constipation and outcomes of interventions are improved by stratification HTBF or HT based on diagnosis (functional defaecation disorder vs. no functional disorder) radio-physiological investigations (INVEST).This a parallel three-arm randomized single-blinded controlled trial, permitting two comparisons: versus alone; INVEST-...
<h3>Introduction</h3> Earlier detection of colorectal and other gastrointestinal malignancies is an urgent objective. Currently much effort directed at the development <i><i>in vitro</i></i> diagnostic tests that evaluate informative protein or DNA biomarkers in stool blood samples. Stool samples are inconvenient to collect, require special handling facilities, suffer from contamination may interfere with molecular assays. Blood samples, while more convenient, not be as early disease...
<h3>Introduction</h3> Earlier detection of colorectal cancer is a clinical priority. Currently very high numbers patients are referred for colonoscopy under the 2 week rule system, with pick up rate 1:20 or less putting major strain on endoscopy units investigating large worried well. The aim this study was to assess correlation protein biomarkers captured from rectal mucosa presence absence cancer. <h3>Method</h3> We conducted case control 20 cancer, and controls. All had been outpatients...
Traditionally, the perineal dissection during an Anbdomeno‐perineal resection of rectum (APER) is conducted in conjunction with trans‐abdominal pelvic patient Lloyd‐Davis and then Lithotomy positions. There a higher local recurrence rate APER as compared to restorative anterior resection. The current practices often result ‘surgical waist’ specimen, which might threaten margin. are many advantages performing prone Jack‐Knife position. oncological benefit that it facilitates achievement more...