A5074541800- Cutaneous Melanoma Detection and Management
- Immunotherapy and Immune Responses
- Ocular Oncology and Treatments
- Melanoma and MAPK Pathways
- Genetic factors in colorectal cancer
- Cancer Genomics and Diagnostics
- vaccines and immunoinformatics approaches
- Fungal Plant Pathogen Control
- IgG4-Related and Inflammatory Diseases
- Vaccine Coverage and Hesitancy
- Colorectal Cancer Screening and Detection
- Prenatal Screening and Diagnostics
- Influenza Virus Research Studies
- Genomics and Rare Diseases
- Colorectal Cancer Treatments and Studies
- Genomic variations and chromosomal abnormalities
- Cutaneous lymphoproliferative disorders research
- Autoimmune and Inflammatory Disorders
- Renal and related cancers
- Cancer Immunotherapy and Biomarkers
- Infectious Diseases and Mycology
- Multiple Myeloma Research and Treatments
- Vasculitis and related conditions
- Virology and Viral Diseases
- Urological Disorders and Treatments
Centre Hospitalier Universitaire de Reims
2015-2022
Université de Reims Champagne-Ardenne
2015-2022
Hôpital Robert-Debré
2020
Laboratoire d'Aérologie
2019
Institut Jean Godinot
2015-2016
Laboratoire Excell
2015
Centre Hospitalier Universitaire de Nantes
2011
As next-generation sequencing increases access to human genetic variation, the challenge of determining clinical significance variants becomes ever more acute. Germline in BRCA1 and BRCA2 genes can confer substantial lifetime risk breast ovarian cancer. Assessment variant pathogenicity is a vital part testing for these genes. A database observations BRCA critical resource that process. This article describes Share™, created by unique international alliance academic centers commercial...
Cutaneous melanocytic tumor with CRTC1::TRIM11 fusion (CMTCT) is a recently described dermally based neoplasm differentiation. It can easily be confused clear cell sarcoma and metastatic melanoma. Our understanding of this lesion, including its potential for aggressive disease, has been limited by the small number previously reported cases (13) clinical follow-up data. Here, we report series 41 CMTCT confirmed molecular studies. We find that lesion shows highly uniform reproducible...
The detection of BRAF mutation in colorectal cancer has several clinical applications: enabling the discrimination between sporadic and Lynch syndrome-related carcinoma, providing warning a poorer prognosis. Few immunohistochemical studies using whole-tissue tumor section staining have recently been performed on cancer. aim this study was to evaluate by immunohistochemistry (IHC) tissue microarray (TMA). IHC with BRAF-specific antibody TMA retrospective series 86 colonic adenocarcinomas...
Few population-based studies on the incidence and prognosis of primary mucosal melanoma (PMM) are available. The first objective was to evaluate disease-specific survival PMM, overall according specific locations, identify prognostic factors. second assess global PMM compared cutaneous specify relative frequency each affected location. A retrospective study incident diagnosed between 2004 2014 conducted, relying regional registry French Champagne-Ardenne region (1.34 million inhabitants)....
e23258 Background: Genetics of melanoma (MM) has greatly progressed in the last decades by discovery mutations BRAF, NRAS and KIT. However, there is a large genetic variability not only tumor to another but also depending on stage disease. In order deepen our knowledge about this for purpose referred therapeutic prognosis we studied 118 MM tumors 73 nevi target next generation sequencing. Methods: After extraction, DNA (44 metastatic tumors, 46 SSM, 11 ALM, 5 nodular, 2 Dubreuilh 3 spitzoid)...