A5070606271- Gut microbiota and health
- Probiotics and Fermented Foods
- Clostridium difficile and Clostridium perfringens research
- Hydrology and Watershed Management Studies
- Genomics and Phylogenetic Studies
- Microbial Metabolites in Food Biotechnology
- Climate variability and models
- Ruminant Nutrition and Digestive Physiology
- Tree-ring climate responses
- Flood Risk Assessment and Management
- Viral gastroenteritis research and epidemiology
- Water resources management and optimization
- Hydrology and Drought Analysis
- Burkholderia infections and melioidosis
- Underwater Acoustics Research
- Social Issues and Policies
- Biochemical and Structural Characterization
- Macrophage Migration Inhibitory Factor
- Meteorological Phenomena and Simulations
- Infant Nutrition and Health
- Vietnamese History and Culture Studies
- Health disparities and outcomes
- Water-Energy-Food Nexus Studies
- Asian American and Pacific Histories
- 14-3-3 protein interactions
NOAA National Marine Fisheries Service Northeast Fisheries Science Center
2024
Northeastern University
2023-2024
University College Cork
2011-2024
APC Microbiome Institute
2016-2024
Universidad del Noreste
2020
Teagasc - The Irish Agriculture and Food Development Authority
2011-2018
National University of Ireland
2018
Woods Hole Oceanographic Institution
2018
Acxiom (United States)
1992
Lactobacilli are gram-positive bacteria that a subdominant element in the human gastrointestinal microbiota, and which commonly used food industry. Some lactobacilli considered probiotic, have been associated with health benefits. However, there is very little culture-independent information on how consumed probiotic microorganisms might affect entire intestinal microbiota. We therefore studied impact of administration Lactobacillus salivarius UCC118, microorganism well characterized for its...
In this study, we characterized the gut microbiota in six healthy Irish thoroughbred racehorses and showed it to be dominated by phyla Firmicutes, Bacteroidetes, Proteobacteria, Verrucomicrobia, Actinobacteria, Euryarchaeota, Fibrobacteres Spirochaetes. Moreover, all horses harboured Clostridium, Fibrobacter, Faecalibacterium, Ruminococcus, Eubacterium, Oscillospira, Blautia Anaerotruncus, Coprococcus, Treponema Lactobacillus spp. Notwithstanding sample size, was noteworthy that core species...
Abstract In this pilot study, we determined the core fecal microbiota composition and overall diversity of domesticated herbivorous animals three digestion types: hindgut fermenters, ruminants, monogastrics. The 42 representing 10 animal species were housed on a single farm in Ireland all large herbivores consumed similar feed, harmonizing two environmental factors that influence microbiota. Similar to other mammals, these was dominated by Firmicutes Bacteroidetes phyla. spanning types...
Abstract Background The genus Lactobacillus is characterized by an extraordinary degree of phenotypic and genotypic diversity, which recent genomic analyses have further highlighted. However, the choice species for sequencing has been non-random unequal in distribution, with only a single representative genome from L. salivarius clade available to date. Furthermore, there no data facilitate functional analysis motility lactobacilli, trait that restricted clade. Results 2.06 Mb bovine isolate...
Ex vivo colon fermentation systems are highly versatile as models for analyzing gastrointestinal tract microbiota composition and functionality. range in size functionality from bench-top micro fermenters to large units housed individualized cabinets. The length of set-up time (including stabilization periods) each system can hours weeks months. aim this study was investigate a single-use cassette mini-fermentation reproducible batch model the colon. online data log cassettes (triplicate...
Lactobacillus ruminis is a poorly characterized member of the salivarius clade that part intestinal microbiota pigs, humans and other mammals. Its variable abundance in human animals may be linked to historical changes over time geographical differences dietary intake complex carbohydrates.In this study, we investigated ability nine L. strains bovine origin utilize fifty carbohydrates including simple sugars, oligosaccharides, prebiotic polysaccharides. The growth patterns were compared with...
Abstract Clostridioides difficile infection (CDI) remains a significant health threat worldwide. C. is an opportunistic, toxigenic pathogen that takes advantage of disrupted gut microbiome to grow and produce signs symptoms ranging from diarrhea pseudomembranous colitis. Antibiotics used treat are usually broad spectrum can further disrupt the commensal microbiota, leaving patients susceptible recurrent infection. There growing need for therapeutic options continue inhibit outgrowth after...
Lactobacillus ruminis is a motile that autochthonous to the human gut, and which may also be isolated from other mammals. Detailed characterization of L. has previously been restricted strains bovine origin. We therefore sought expand our bio-bank identify characterise isolates porcine equine origin by comparative genomics. five faeces horses two pigs, compared their motility, biochemistry genetic relatedness six three including type strain 27780T. Multilocus sequence typing analysis based...
Abstract The Mississippi River represents a major commercial waterway, and periods of anomalously low river levels disrupt riverine transport. These low-flow events occur periodically, with recent event in the fall 2022 slowing barge traffic generating sharp increases transportation costs. Here we combine instrumental gage observations from lower output Community Earth System Model v2 Large Ensemble (LENS2) to evaluate historical trends future projections streamflow extremes, place broader...
In the wet-dry tropics of Northern Australia, drinking water in remote communities is mostly sourced from bores accessing groundwater. Many aquifers contain naturally high levels iron and some are shallow with surface intrusion wet season. Therefore, environmental bacteria such as iron-cycling promoting biofilm formation pipes or opportunistic pathogens can occur these waters. An pathogen endemic to northern Australia Southeast Asia emerging worldwide Burkholderia pseudomallei. It causes...
The Centers for Disease Control and Prevention estimate that Clostridioides difficile (C. difficile) causes half a million infections (CDI) annually is major cause of total infectious disease death in the United States, causing inflammation colon potentially deadly diarrhea. We recently reported isolation ADS024, Bacillus velezensis (B. velezensis) strain, which demonstrated direct vitro bactericidal activity against C. difficile, with minimal collateral impact on other members gut...
Abstract. The Mississippi River is a critical waterway in the United States, and hydrologic variability along its course represents perennial threat to trade, agriculture, industry, economy, communities. Community Earth System Model version 1 (CESM1) complements observational records of river discharge by providing fully coupled output from state-of-the-art earth system model that includes transport model. These simulations past, historic, projected have been widely used assess dynamics...
Abstract The Mississippi River is a vital economic corridor used for generating hydroelectric power, transporting agricultural products, and municipal industrial water use. Communities, industries, infrastructure along the face an uncertain future as it grows more susceptible to climate extremes. A key challenge determining whether river discharge will increase or decrease during 21st century. Because 20th century record limited in time, paleoclimate data model simulations provide enhanced...
Neuroinflammation is a common component of neurological disorders. In the gut-brain-immune axis, bacteria and their metabolites are now thought to play role in modulation nervous immune systems which may impact neuroinflammation. this respect, commensal humans have recently been shown produce that mimic endogenous G-protein coupled receptor (GPCR) ligands. To date, it has not established whether plant bacteria, be ingested by animals including humans, can axis via GPCR agonism. We screened...
We report the draft genome sequence of Lactobacillus equi strain DPC6820, isolated from equine feces. L. is a predominant species in horse hindgut microbiota. An examination identified genes and enzymes highlighting adaptations to herbivorous gastrointestinal tract horse, including fructan hydrolases. This may help us further understand microbial ecology influence lactobacilli have on it.
Introduction: Recurrence of C. difficile infection (CDI) is due to the failure antibiotics eradicate spores that can germinate post-treatment. ADS024, an orally delivered single-strain live biotherapeutic product (Bacillus velezensis), kills and degrades its toxins. This study (NCT04891965) evaluated safety efficacy ADS024 for prevention CDI recurrence (rCDI). Methods: The phase 1b, randomized, placebo-controlled, double-blind, multicenter enrolled patients cured after a course...