A5075054108- Cancer Cells and Metastasis
- Cancer Genomics and Diagnostics
- Sarcoma Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Prostate Cancer Treatment and Research
- Chromatin Remodeling and Cancer
- Autoimmune and Inflammatory Disorders Research
- COVID-19 and healthcare impacts
- Neurofibromatosis and Schwannoma Cases
- Infectious Diseases and Tuberculosis
- Cancer Mechanisms and Therapy
- Neuroblastoma Research and Treatments
- Sexual function and dysfunction studies
- Lung Cancer Research Studies
- Fungal Infections and Studies
- Maternal Mental Health During Pregnancy and Postpartum
- PARP inhibition in cancer therapy
- Systemic Sclerosis and Related Diseases
- Mycobacterium research and diagnosis
- Cutaneous Melanoma Detection and Management
- Pharmacology and Obesity Treatment
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Glycosylation and Glycoproteins Research
- Animal Genetics and Reproduction
- Perfectionism, Procrastination, Anxiety Studies
Informa Healthcare
2024
British Columbia Children's Hospital
2015-2023
University of British Columbia
2003-2021
Digital Research Alliance of Canada
2021
Psoriasis Association
2021
Epic Sciences (United States)
2015-2020
Western Sydney University
2019
New South Wales Department of Health
2019
Princess Margaret Cancer Centre
2005
Vancouver General Hospital
2005
P. L. Hewitt and G. Flett's (1991b) model of perfectionism dimensions (i.e., self-oriented, other-oriented, socially prescribed perfectionism) was compared with A. T. Beck's (G. Brown & A.T. Beck, 2002) dysfunctional attitudes perfectionistic [PA] dependent [DA]) in predicting depression 70 psychiatric patients 280 university students. Socially uniquely predicted both PA DA. Dysfunctional failed to consistently predict additional variance beyond (and vice versa). Evidence for specific...
No AccessJournal of UrologyAdult Urology: Sexual Function/Infertility1 Aug 2005EVIDENCE FOR CONTAMINATION OF HERBAL ERECTILE DYSFUNCTION PRODUCTS WITH PHOSPHODIESTERASE TYPE 5 INHIBITORS NEIL FLESHNER, MELISSA HARVEY, HANS ADOMAT, CATHERINE WOOD, ANDY EBERDING, KAREN HERSEY, and EMMA GUNS FLESHNERNEIL FLESHNER , HARVEYMELISSA HARVEY ADOMATHANS ADOMAT WOODCATHERINE WOOD EBERDINGANDY EBERDING HERSEYKAREN HERSEY GUNSEMMA View All Author...
Abstract Poorly differentiated chordoma (PDC) is a recently recognized subtype of characterized by expression the embryonic transcription factor, brachyury, and loss INI1. PDC primarily affects children associated with poor prognosis limited treatment options. Here we describe molecular immune tumour microenvironment profiles two paediatric PDCs produced using whole-genome, transcriptome whole-genome bisulfite sequencing (WGBS) multiplex immunohistochemistry. Our analyses revealed presence...
Here we describe the development of a protein immunofluorescent assay for detection nuclear-localized androgen receptor variant 7 (AR-V7) within circulating tumor cells (CTCs) identified in patient blood samples. Used clinic, test result serves as validated biomarker futility patients with progressing metastatic castration-resistant prostate cancer (mCRPC) who are treated targeted therapies (AATT) whom AR-V7 CTCs and have received level 2A evidence 2019 National Cancer Center Network (NCCN)...
Mass lesions presenting at the craniocervical junction often present a unique challenge due to complex anatomic arrangement limiting access for tissue diagnosis. The transoral approach has predominantly been used percutaneous vertebroplasty of high cervical vertebrae with limited literature describing image guided biopsy bony in this region pediatric patient. We describe technique computed tomography poorly differentiated chordoma located C1-C2 level 5-year-old child, and review
Malignant rhabdoid tumors and atypical teratoid/rhabdoid of the central nervous system are primitive malignancies associated with a poor prognosis. These have previously been characterized by inactivation switch/sucrose nonfermenting (SWI/SNF) chromatin remodeling complex protein integrase interactor 1 (INI1), encoded SMARCB1 gene. In last decade, sporadic publications shown that different SWI/SNF protein, brahma-related gene (BRG1), SMARCA4 gene, is similar phenotype possible germline...
Retrospective analysis of patient tumour samples is a cornerstone clinical research. CTC biomarker characterization offers non-invasive method to analyse samples. However, current technologies require prospective blood collection, thereby reducing the ability utilize archived cohorts with long-term outcome data. We sought investigate recovery from frozen, PBMC pellets. Matched both mCRPC patients and mock samples, which were prepared by spiking healthy donor cultured prostate cancer cell...
We present the case of a 3-year-old boy who was diagnosed with cerebral abscesses due to Aspergillus nidulans infection on day 28 induction chemotherapy for acute lymphoblastic leukemia. He responded well treatment voriconazole and caspofungin, making full recovery. There are very few cases invasive aspergillosis reported in children during leukemia A. is rare absence chronic granulomatous disease.
Experts probably have to immerse themselves in their discipline for at least a decade before they the knowledge and insights needed produce world-class work. Medical practitioners with long experience specialist fields are particularly well placed know what type of devices might be make patients’ journeys back health more comfortable, secure cost-effective. school curriculae, however, devoid formal innovation business training UK. The strategies required convert an idea into reality remain...
You have accessJournal of UrologyPodium, Monday, May 10, 2004, 1:00 - 3:00 pm1 Apr 20041190: Evidence for Pharmacological Contamination Herbal Erectile Function Products with type 5 Phosphodiesterase (PDES)Inidbitors Neil E. Fleshner, Melissa Harvey, Hans Adomat, Catherine Wood, Karen Hersey, and Emma Guns FleshnerNeil Fleshner More articles by this author , HarveyMelissa Harvey AdomatHans Adomat WoodCatherine Wood HerseyKaren Hersey GunsEmma View All Author...
Abstract Introduction: Current CTC detection platforms require the processing of patient blood within 48 hrs after collection to preserve integrity and biomarker expression. Here we demonstrate recovery CTCs from banked samples that have been cryopreserved for up 7 years. Our results show equivalent morphology protein expression patterns as in freshly processed are suitable genomic analyses. This process enables retrospective studies inclusive enumeration, quantification, FISH analysis via...
Abstract Melanoma is rare in pediatric patients and even more so those with darker Fitzpatrick skin types. Although risk factors for conventional melanoma are similar both adult cases, the presentation of often distinct from adults. Here, we describe a case amelanotic ulcerated nodular regional lymph node metastases treated nivolumab patient type VI.
194 Background: Upregulation of GR protein expression in metastatic biopsies from pts with CRPC has previously been shown to correlate resistance enzalutamide and validated as a therapeutic target pre-clinical studies. We sought determine whether upregulated CTCs progressing mCRPC predicted clinical outcomes following treatment (E) or abiraterone (A). Methods: Pre-therapy blood samples 54 were subjected CTC analysis using the Epic Sciences platform. Samples examined identify CK+ (CK+, CD45-...
Mycoplasma orale is an obligate intracellular bacterium usually found as a commensal in the human oral cavity. Symptomatic infections with this organism are rare, but severe disease has been described setting of impaired humoral immunity. Here, we describe case which M. was identified from joint fluid patient septic arthritis, splenic lesions, and agammaglobulinemia. A 15-year-old boy admitted to hospital fever, progressive left knee swelling, pain. His medical history significant for...
Tumors of the central nervous system (CNS) in pediatric patients have undergone significant diagnostic refinement through use immunohistochemistry (IHC) and molecular techniques. The utility these novel IHC antibodies has been demonstrated with inactivation switch/sucrose nonfermenting (SWI/SNF) chromatin-remodeling complex diagnosis atypical teratoid/rhabdoid tumors, predominantly loss integrase interactor 1 (INI1; SMARCB1 ). Alternatively, tumors may brahma-related gene (BRG1; SMARCA4 ) a...
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