A5079703318- Nicotinic Acetylcholine Receptors Study
- Receptor Mechanisms and Signaling
- Hearing, Cochlea, Tinnitus, Genetics
- Ion channel regulation and function
- Neurobiology and Insect Physiology Research
- Photoreceptor and optogenetics research
- Cholinesterase and Neurodegenerative Diseases
- Circadian rhythm and melatonin
- Genetics, Aging, and Longevity in Model Organisms
- Genetics and Neurodevelopmental Disorders
- Marine animal studies overview
Consejo Nacional de Investigaciones Científicas y Técnicas
2019-2024
Instituto de Biomedicina y Genética Molecular de Valladolid
2024
Experimental Medicine and Biology Institute
2020
National University of Quilmes
2020
Abstract The expansion and pruning of ion channel families has played a crucial role in the evolution nervous systems. Nicotinic acetylcholine receptors (nAChRs) are ligand-gated channels with distinct roles synaptic transmission at neuromuscular junction, central peripheral system, inner ear. Remarkably, complement nAChR subunits been highly conserved along vertebrate phylogeny. To ask whether different subtypes underwent evolutionary trajectories, we performed comprehensive analysis nAChRs...
The lateral line (LL) is a sensory system that allows fish and amphibians to detect water currents. LL responsiveness modulated by efferent neurons aid in distinguishing between external self-generated stimuli, maintaining sensitivity relevant cues. One component of the cholinergic, activation which inhibits afferent activity. hair cells (HCs) share structural, functional, molecular similarities with those cochlea, making them popular model for studying human hearing balance disorders....
The α9α10 nicotinic acetylcholine receptor (nAChR) plays a fundamental role in inner ear physiology. It mediates synaptic transmission between efferent olivocochlear fibers that descend from the brainstem and hair cells of auditory sensory epithelium. α9 α10 subunits have undergone distinct evolutionary history within family nAChRs. Predominantly mammalian vertebrates, has accumulated changes at protein level may ultimately relate to hearing organ. In present work, we investigated responses...
<title>Abstract</title> The α9α10 nicotinic cholinergic receptor (nAChR) is a ligand-gated pentameric cation-permeable ion channel that mediates synaptic transmission between descending efferent neurons and mechanosensory inner ear hair cells. When expressed in heterologous systems, α9 α10 subunits can assemble into functional homomeric heteromeric receptors. One of the differential properties these nAChRs modulation their ACh-evoked responses by extracellular calcium (Ca<sup>2+</sup>)....
The α9α10 nicotinic cholinergic receptor (nAChR) is a ligand-gated pentameric cation-permeable ion channel that mediates synaptic transmission between descending efferent neurons and mechanosensory inner ear hair cells. When expressed in heterologous systems, α9 α10 subunits can assemble into functional homomeric heteromeric receptors. One of the differential properties these nAChRs modulation their ACh-evoked responses by extracellular calcium (Ca
ABSTRACT The expansion and pruning of ion channel families has played a crucial role in the evolution nervous systems. Remarkably, with highly conserved vertebrate complement, nicotinic acetylcholine receptors (nAChRs) are unique among ligand-gated channels that members family have distinct roles synaptic transmission non-overlapping domains, either system, inner ear hair cells or neuromuscular junction. Here, we performed comprehensive analysis nAChRs sequences, single cell expression...
Abstract The lateral line (LL) is a sensory system that allows fish and amphibians to detect water currents. LL responsiveness external stimuli modulated by descending efferent neurons. modulation aids the animal distinguish between self-generated stimuli, maintaining sensitivity relevant cues. One of main components cholinergic, activation which inhibits afferent activity. Since hair cells (HC) share structural, functional molecular similarities with those cochlea, one could propose...
Abstract The α9α10 nicotinic acetylcholine receptor (nAChR) plays a fundamental role in inner ear physiology. It mediates synaptic transmission between efferent olivocochlear fibers that descend from the brainstem and hair cells of auditory sensory epithelium. α9 α10 subunits have undergone distinct evolutionary history within family nAChRs. Predominantly mammalian vertebrates, has accumulated changes at protein level may ultimately relate to hearing organ. In present work we investigated...