A5001101927- Wound Healing and Treatments
- Surgical site infection prevention
- Immune cells in cancer
- Reconstructive Surgery and Microvascular Techniques
- Hernia repair and management
- Colorectal Cancer Treatments and Studies
- Cancer Risks and Factors
- Click Chemistry and Applications
- Birth, Development, and Health
- Cancer Immunotherapy and Biomarkers
- Trauma Management and Diagnosis
- Nanoplatforms for cancer theranostics
- Chemokine receptors and signaling
- Extracellular vesicles in disease
- Monoclonal and Polyclonal Antibodies Research
- Lung Cancer Research Studies
- Body Contouring and Surgery
- Polymer composites and self-healing
- Cancer Research and Treatments
- Esophageal and GI Pathology
- Brain Metastases and Treatment
- Diagnosis and Treatment of Venous Diseases
- Abdominal Surgery and Complications
- Cutaneous Melanoma Detection and Management
- Lymphoma Diagnosis and Treatment
Allegheny Health Network
2016-2021
Allegheny General Hospital
2016
University of Pittsburgh Medical Center
2004-2007
Magee-Womens Hospital
2000-2007
University of Pittsburgh
1983-2004
UPMC Presbyterian
1983
Reconstruction of massive abdominal wall defects has long been a vexing clinical problem. A landmark development for the autogenous tissue reconstruction these difficult wounds was introduction "components anatomic separation" technique by Ramirez et al. This method uses bilateral, innervated, bipedicle, rectus abdominis-transversus abdominis-internal oblique muscle flap complexes transposed medially to reconstruct central wall. Enamored with this concept, institution sought define...
Minimally invasive surgery has gained popularity in the last decade and its applications to plastic are expanding. Pedicled omental flaps used for reconstruction of chest wall defects following debridement sternal infections mediastinitis. The main advantages using an flap large size bulk fill 3-dimensional dead spaces, long pedicle, rich vascular lymphatic networks. Recently, laparoscopic techniques have been described harvesting flaps. Over 5 years our institution, 9 harvests were...
Treating burn-related injuries remains challenging, because of donor site morbidity, bacterial infection, and major scarring. Recent advances have led to the development promising natural synthetic polymer scaffolds, objective which is regenerate skin using a "top-down" approach, in top layers populated by fibroblasts keratinocytes are regenerated first. An often-overlooked component integumentary system subcutaneous adipose tissue, has been implicated variety activities, including wound...
Surgical meshes have become the standard procedure for a variety of surgical applications with 20 million being implanted each year. The popularity mesh usage among surgeons is backed by multiple studies that support its functionality as tool improving outcomes. However, their use has also been associated infectious complications and many turned to biologic meshes. While there several investigating synthetic meshes, limited data comparing in vitro an infection model. This study evaluates...
Needle catheter jejeunostomy is a useful method for providing fluid and nutritional support in selected patients after laparotomy. The technique widely used, complications are infrequent. We report herein new complication of this procedure. A cirrhotic patient with portal hypertension underwent needle subsequent to esophageal transection hemorrhage. functioned satisfactorily the postoperative period was removed before discharge. Approximately 1 yr later, gastrointestinal hemorrhage recurred...
854
3027 Background: The appropriate subgroup of melanoma patients to select for high-dose IFNa2b (HDI) adjuvant therapy has been undefined since approval this modality in 1996. A biomarker clinical practice and relevant the biological effects agent would be great importance. IFNAR2 is required type I IFN-dependent signaling. Therefore, response during HDI was evaluated a prospective neoadjuvant trial HDI. Methods: Following diagnostic biopsy before definitive surgery, administered as with stage...
854 Background: Pregnancy-associated breast carcinoma is defined as cancer diagnosed either during pregnancy or one year post partum. Pregnancy may delay diagnosis and/or therapy and potentially worsen outcomes. Methods: We evaluated the presentation survival outcomes of 47 consecutive patients presenting with <1 after at our institution between 1990 2001 compared them to age- stage-matched women drawn from a national data base. One woman cystocsarcoma phylloides another desmoid tumor are...
Abstract Even the most therapy responsive melanomas eventually evade immune checkpoint inhibition. Interestingly, initial responses seem to benefit from localized inflammation, but this can become prohibitive when treating advanced disease. Subsequently, there is an urgent need elucidate how inflammation impacts tumor microenvironment (TME). Here, inhibition of EGFR and Ras/Raf/MEK shown drive release a pro-inflammatory secretome that activates TME promote progression. This was enriched with...
Abstract How microenvironmental inflammation impacts melanoma progression remains controversial. Inflammation appears beneficial during interferon stimulated expression of checkpoint targets. However, when tipped too far, therapy-driven has been linked to debilitating autoimmune disease in cancer patients. One unanswered question is whether this also promotes dissemination. Here, drug-stressed melanomas are shown promote via a pro-inflammatory secretome that activates the tumor...