A5069810828- Synthesis and biological activity
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis and Biological Evaluation
- Dyeing and Modifying Textile Fibers
- Click Chemistry and Applications
- Synthesis of heterocyclic compounds
- Crystal structures of chemical compounds
- Multicomponent Synthesis of Heterocycles
- Cancer therapeutics and mechanisms
- Crystallography and molecular interactions
- Synthesis and Reactions of Organic Compounds
- Photochromic and Fluorescence Chemistry
- 2D Materials and Applications
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Dye analysis and toxicity
- Free Radicals and Antioxidants
- Fungal Plant Pathogen Control
- DNA and Nucleic Acid Chemistry
- Synthesis and Reactivity of Heterocycles
- Synthesis of Tetrazole Derivatives
- Mechatronics Education and Applications
- Chemical Synthesis and Analysis
- Structural and Chemical Analysis of Organic and Inorganic Compounds
University of Zagreb
2012-2024
Pliva (Croatia)
2011-2024
A series of new diamidino-, diisopropylamidino-, and diimidazolinyl-substituted derivatives phenyl benzothiazolyl dibenzothiazolyl furans thiophenes were successfully prepared evaluated for their antiproliferative activity on tumor cell lines in vitro, DNA binding propensity, sequence selectivity as well cellular distribution. strong effect the tested compounds was observed all a concentration-dependent response pattern. In general, imidazolinyl-substituted and/or thiophene core correlation...
In the multistep syntheses of title compounds we obtained some new cyano-substituted heterocycles (1a, 1b, 2a, and 2b) as intermediates.Starting from dinitriles (2a well two formerly prepared dinitriles, substituted bisamidines (3a, 3b, 5a, 5b, 7a, 7b) amidino dihydrochlorides (4a, 4b, 6a, 6b, 8a, 8b, 9a, 9b) have been synthesized.2][3] The amidine group at termini molecules seemed to contribute significantly dications DNA 4,5 complex stability.A number aromatic shown bind in minor groove on...
Newly designed and synthesized cyano, amidino acrylonitrile 2,5-disubstituted furane derivatives with either benzimidazole/benzothiazole nuclei have been evaluated for antitumor antimicrobial activity. For potential activity, the compounds were tested in 2D 3D cell culture methods on three human lung cancer lines, A549, HCC827 NCI-H358, MTS cytotoxicity BrdU proliferation assays vitro. Compounds 5, 6, 8, 9 15 proven to be activity high stop of cells. In general, benzothiazole more active...
Novel derivatives of 6-amino-2-phenylbenzothiazole bearing differentsubstituents (amino, dimethylamino or fluoro) on the phenyl ring were prepared as thecorresponding hydrochloride salts. 6-Nitro-2-(substituted-phenyl)benzothiazoles (1-6) weresynthesized by condensation reactions substituted benzaldehydes with 2-amino-5-nitrothiophenol. Nitro reduced to amino SnCl2/HCl.Water soluble salts 6-amino-2-(substituted-phenyl)benzothiazole (13-19)were using concentrated gaseous HCl. Compounds 13-19...
Newly synthesised benzimidazole/benzotiazole derivatives bearing amidino, namely 3,4,5,6-tetrahydropyrimidin-1-ium chloride, substituents have been evaluated for their potential antitumor activity in vitro. Compounds and standard drugs (doxorubicin, staurosporine vandetanib) were tested on three human lung cancer cell lines A549, HCC827 NCI-H358. We compounds MTS citotoxicity assay BrdU proliferative performed 2 D 3 format. Because benzmidazole scaffold is similar to natural purines, we the...
A new synthetic strategy involving the Pinner reaction offers various amidino-functionalized 2-substituted benzoxazoles<italic>via</italic>amidino-substituted 2-aminophenols with sub-micromolar antiproliferative activities.
Herein we present the design and synthesis of novel substituted coumarin–benzimidazole/benzothiazole hybrids bearing a cyclic amidino group on benzazole core as biologically active agents.
The new compounds 2-[4-(6-cyanobenzothiazol-2-yl)phenyl]-5-(6-cyano-benzothiazol-2-yl)furan (6a) and 2-[4-(6-Cyanobenzothiazol-2-yl)phenyl]-5-(6-cyano-benzothiazol-2-yl)thiophene (6b) were synthesized by multi-step reactions from the corresponding 2-furan 2-thiophene carboxaldehydes (route A), as well 2- thiophene carboxylic acids B). Route B involves one less step than route A, but overall yields of are considerably lower.
Chemical composition, antioxidant activity and in vitro antibacterial of propolis from the central, continental part Croatia were studied.Propolis hydro-ethanolic extracts (PHEE), prepared using three different methods two solvent mixtures contained high amounts flavonoids (20.95-28.11% TIC), aromatic acids (8.17-15.91 % TIC) their esters (9.27-11.91 TIC).The PHEE obtained this study showed (DPPH IC50 values 9.96-19.95µg/ml FRAP 38.0-41.9mM Fe 2+ /mg PHEE).Despite differences samples...
Herein we present the synthesis of versatile amidino substituted benzothiazole 3-10 and benzimidazole 12-19 derivatives with variable number hydroxy methoxy groups.Furthermore, synthesized compounds were explored for their antioxidative activity in vitro by using three biological assays, namely DPPH, ABTS FRAP.The obtained results indicated that groups together type substituent strongly influenced reducing power tested compounds.The most promising showed trihydroxy 6, 10, 15 19.In general,...
Background: Differently substituted thiophenes are largely studied due to their diverse pharmacological properties, especially anticancer activity. Recent studies have reported on interesting benzothiophene compounds antitumor properties and we also recently the synthesis, strong activities DNA binding features of thieno[3&#039;,2&#039;:4,5]thieno- benzo[b]thieno[2,3-c]quinolones, containing different substituents, mostly amidino- or groups. </p> <p> Objective: The...
A series of 6-amidinobenzothiazoles, linked via phenoxymethylene or directly to the 1,2,3-triazole ring with a p-substituted phenyl benzyl moiety, were synthesised and evaluated in vitro against four human tumour cell lines protozoan parasite Trypanosoma brucei. The influence type amidino substituent linker on antiproliferative antitrypanosomal activities was observed, showing that imidazoline moiety had major impact both activities. Benzothiazole 14a, which connected...
We present a simple method for modification of 2D materials by drop-casting the organic molecule in solution on material under ambient conditions. Specifically, we investigated adsorption 6-(4,5-Dihydro-1H-imidazol-3-ium-2-yl)-2-(naphthalene-2-yl)benzothiazole methanesulfonate (L63MS) MoS2. To better understand effect material, also impact solvents alone materials’ properties. The MoS2 samples were synthesized using pressure chemical vapor deposition. Atomic force microscopy, Raman...