A5058728641- Platelet Disorders and Treatments
- Immune Cell Function and Interaction
- Immune cells in cancer
- Blood properties and coagulation
- Immune responses and vaccinations
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Tryptophan and brain disorders
- Mast cells and histamine
- Public Health Policies and Education
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Erythrocyte Function and Pathophysiology
- Single-cell and spatial transcriptomics
- Immunodeficiency and Autoimmune Disorders
- Healthcare cost, quality, practices
- Climate Change and Health Impacts
- Neonatal Respiratory Health Research
- Phagocytosis and Immune Regulation
- Galectins and Cancer Biology
- Pulmonary Hypertension Research and Treatments
- Blood disorders and treatments
- IL-33, ST2, and ILC Pathways
- Inflammasome and immune disorders
- Immune Response and Inflammation
- Inflammatory Biomarkers in Disease Prognosis
University of Rochester
2020-2024
University of Rochester Medical Center
2022-2024
Cardiovascular Institute Hospital
2020-2023
Although platelets are the cellular mediators of thrombosis, they also immune cells. Platelets interact both directly and indirectly with cells, impacting their activation differentiation, as well all phases response. Megakaryocytes (Mks) cell source circulating platelets, until recently Mks were typically only considered bone marrow-resident (BM-resident) However, platelet-producing reside in lung, lung express greater levels molecules compared BM Mks. We therefore sought to define...
While platelets have well-studied hemostatic functions, are immune cells that circulate at the interface between vascular wall and white blood cells. The physiological implications of these constant transient interactions poorly understood. Activated induce amplify responses, but may also maintain homeostasis in healthy conditions, including maintaining integrity T helper cell differentiation, meaning central to both responses quiescence. Clinical data shown an association low platelet...
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Lung megakaryocytes (Mks) are largely extravascular with an immune phenotype (1). Because bone marrow (BM) Mks short-lived it has been assumed that lung constantly 'seeded' from the BM. To investigate Mk origins and how impacts their functions, we developed methods to specifically label using CFSE dye biotin delivered oropharyngeal. Labeled were present for up four months, while BM had a <1 week lifespan. In parabiosis model, partially replaced over 1-month circulating source. Unlike...
Abstract In addition to their well-studied hemostatic functions, platelets are immune cells. Platelets circulate at the interface between vascular wall and leukocytes, transient platelet-leukocyte complexes found in both healthy disease states, positioning provide physiologic cues of health injury. Roles for activated inducing amplifying responses have received an increasing amount research attention, but our past studies also showed that normal platelet counts needed conditions maintain...
<b>Introduction:</b> E-cigarette use remains a significant health risk with ≥3 million adolescents and young adults admitting to regular in the United States alone. One of previously identified risks combustible cigarettes is myelosuppression. The purpose current study was evaluate for similar myelosuppressive effects mice exposed e-cigarette aerosols. <b>Methods:</b> Adolescent C57/Bl6 male female were aerosols (PG/VG with/out nicotine) or purified air two weeks via whole body exposures....
Abstract We previously characterized lung megakaryocytes (Mks) as largely extravascular cells with an immune modulatory phenotype (Pariser et al., 2021). Because bone marrow (BM) Mks are relatively short lived, it is assumed that constantly ‘seeded’ from the BM, but there no experimental data to validate this concept. To investigate Mk origin and how their may impact functions, we developed novel models using CFSE dye delivered oropharyngeal (OP) biotin labeling specifically label identify...
In addition to their well-studied hemostatic functions, platelets are immune cells. Platelets circulate at the interface between vascular wall and leukocytes, transient platelet-leukocyte complexes found in both healthy disease states, positioning provide physiologic cues of health injury. Roles for activated inducing amplifying responses have received an increasing amount research attention, but our past studies also showed that normal platelet counts needed conditions maintain homeostasis....
Background: Thrombosis, precipitated by dysregulated platelet responses, contributes to adverse clinical outcomes, including organ failure and death during systemic inflammation (e.g., sepsis).Previously, our lab identified interferon-induced transmembrane protein 3 (IFITM3) as a mediator of antiviral responses in platelets MKs inflammation.Whether IFITM3 mediates functions subsequent pro-thrombotic has not been previously examined.Aims: To define the role inflammation.Methods:...
The malaria causing Plasmodium parasite is a major public health threat. vivax (P vivax) the cause of uncomplicated (UCM). Platelets are cellular mediators thrombosis and also most numerous immune cells in blood, first responder to infections. Thrombocytopenia frequent complication malaria, decrease platelet count negative predictor disease outcome. Malaria infection elicits strong interferon gamma (IFNγ) response. IFNγ potent inducer indoleamine 2,3-dioxygenase (IDO1) rate-limiting enzyme...