A5060455352- Blood groups and transfusion
- Erythrocyte Function and Pathophysiology
- Hemoglobinopathies and Related Disorders
- Neonatal Health and Biochemistry
- Blood disorders and treatments
- Immunodeficiency and Autoimmune Disorders
- Streptococcal Infections and Treatments
- Blood properties and coagulation
- Hemoglobin structure and function
- Microbial infections and disease research
- Cholinesterase and Neurodegenerative Diseases
- Glycosylation and Glycoproteins Research
- Monoclonal and Polyclonal Antibodies Research
- Cytomegalovirus and herpesvirus research
- RNA regulation and disease
- Genetic Neurodegenerative Diseases
- Computational Drug Discovery Methods
- Amyloidosis: Diagnosis, Treatment, Outcomes
- RNA modifications and cancer
- Blood transfusion and management
- Immune Cell Function and Interaction
- Blood donation and transfusion practices
- Peroxisome Proliferator-Activated Receptors
- Complement system in diseases
- RNA Research and Splicing
University of Manitoba
2006-2018
New York Blood Center
1995-2013
Research Manitoba
1992-2013
Japanese Red Cross Society, Japan
2013
Emory University
2005-2010
Children's Hospital Research Institute of Manitoba
2004-2009
Duke Medical Center
2000
Massachusetts General Hospital
2000
American Red Cross
2000
Washington University in St. Louis
2000
Severe combined immunodeficiency (SCID) comprises a heterogeneous group of heritable deficiencies humoral and cell-mediated immunity. Many patients with SCID have lymphocyte-activation defects that remain uncharacterized.We performed genetic studies in four patients, from families Northern Cree ancestry, who had clinical characteristics SCID, including early onset severe viral, bacterial, fungal infections despite normal B-cell T-cell counts. Genomewide homozygosity mapping was used to...
The International Society of Blood Transfusion Working Party on red cell immunogenetics and blood group terminology convened during the congress in Cancun, July 2012. This report details newly identified antigens existing systems presents three new systems.
The Committee met in Cape Town during the 2006 International Society of Blood Transfusion (ISBT) Congress (see Appendix 1 for members). Some changes to classification documented Group Terminology 2004 [1] were agreed and are described below. full updated can be found on website at http://www.blood.co.uk/ibgrl. New antigens added MNS, Kell, Scianna, Cromer, Indian, Knops, JMH systems (Table 1). In line with convention, amino acid positions numbered translation-initiating methionine as 1,...
The committee met in Macao Special Administrative Region, China, during the 2008 International Society of Blood Transfusion (ISBT) Congress. Some changes to classification documented Group Terminology 2004 [1] and updated 2007 [2] were agreed are described below. full can be found on blood group terminology website at http://www.blood.co.uk/ibgrl. A new system, RHAG was established antigens added Rh, Kell, Dombrock systems (Table 1). total 308 now recognized, 270 which clustered 30 systems....
Ritscher-Schinzel syndrome (RSS) is a clinically heterogeneous disorder characterised by distinctive craniofacial features in addition to cerebellar and cardiac anomalies. It has been described different populations presumed follow autosomal recessive inheritance. In an effort identify the underlying genetic cause of RSS, affected individuals from First Nations (FN) community northern Manitoba, Canada, were enrolled this study.Homozygosity mapping SNP array Sanger sequencing candidate genes...
In 1901, Landsteiner named the first two blood group antigens A and B, using letters of al- phabet.1 RBCs not reacting with anti-A anti-B were called type C.1 1902, von Decastello Sturli2 described both but did give this a name; they continued calling that react C. publication in 1910,3 showed serologic results all four ABO types use terms O AB. 1911, Dungern Hirszfeld4 appear to be term describe AB for anti-B. The lack B was indicated by letter "O", it is controversial whether should have...
The pathways leading to the formation of phosphatidylethanolamine in isolated hamster hearts were investigated. contributions CDP-ethanolamine and base exchange studied by perfusion with [ 3 H]ethanolamine. radioactivity ethanolamine heart reached a maximum at 5 min remained constant throughout period. Maximum labeling phosphoethanolamine occurred 25 did not reach over 30-min-perfusion Incorporation into was marked lag during first 15 perfusion, after which linear increase observed. This...