A5043450784- RNA modifications and cancer
- Phagocytosis and Immune Regulation
- RNA regulation and disease
- Calcium signaling and nucleotide metabolism
- RNA and protein synthesis mechanisms
- Tryptophan and brain disorders
- PARP inhibition in cancer therapy
- Cell Adhesion Molecules Research
- COVID-19 Clinical Research Studies
- Biochemical and Molecular Research
- Cancer-related Molecular Pathways
- Glycogen Storage Diseases and Myoclonus
- Ocular Disorders and Treatments
- Thermal Regulation in Medicine
- Sphingolipid Metabolism and Signaling
- Fibroblast Growth Factor Research
- Lysosomal Storage Disorders Research
- Intensive Care Unit Cognitive Disorders
- Liver physiology and pathology
- Long-Term Effects of COVID-19
- Silk-based biomaterials and applications
- Wnt/β-catenin signaling in development and cancer
- Connective tissue disorders research
- Lipid Membrane Structure and Behavior
- RNA Research and Splicing
University of Cologne
2015-2024
Royal Berkshire NHS Foundation Trust
2024
University Hospital Cologne
2023
Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases
2021
University of Manitoba
2009-2015
Children's Hospital Research Institute of Manitoba
2009-2015
Abstract The extracellular matrix architecture is composed of supramolecular fibrillar networks that define tissue specific cellular microenvironments. Hemicentins (Hmcn1 and Hmcn2) are ancient very large members (> 600 kDa) the fibulin family, whose short known to guide proper morphology functional behavior specialized cell types predominantly in elastic tissues. However, distribution function within microenvironment connective tissues has remained largely unknown. Performing situ...
Several studies have revealed a correlation between chronic inflammation and nicotinamide adenine dinucleotide (NAD + ) metabolism, but the precise mechanism involved is unknown. Here, we report that genetic pharmacological inhibition of phosphoribosyltransferase (Nampt), rate-limiting enzyme in salvage pathway NAD biosynthesis, reduced oxidative stress, inflammation, keratinocyte DNA damage, hyperproliferation, cell death zebrafish models skin while all these effects were reversed by...
Bowen-Conradi syndrome (BCS) is a lethal autosomal recessive disorder caused by D86G substitution in the protein, Essential for Mitotic Growth 1 (EMG1). EMG1 essential 18S rRNA maturation and 40S ribosome biogenesis yeast, but no studies of its role have been done mammals. To assess effect mutation on cell growth ribosomal humans, we employed BCS patient cells. The did not interfere with nucleolar localization. In lymphoblasts, cells accumulated G2/M, resulting reduced proliferation rates;...
The type II transmembrane serine protease Matriptase 1 (ST14) is commonly known as an oncogene, yet it also plays understudied role in suppressing carcinogenesis. This double face evident the embryonic epidermis of zebrafish loss-of-function mutants cognate inhibitor Hai1a (Spint1a). Mutant embryos display epidermal hyperplasia, but apical cell extrusions, during which extruding outer keratinocytes carry out entosis-like engulfment and entrainment underlying basal cells, constituting a...
Summary Several studies have revealed a correlation between chronic inflammation and NAD + metabolism but the precise mechanism involved is unknown. Here we report that genetic pharmacological inhibition of nicotinamide phosphoribosyltransferase (Nampt), rate-limiting enzyme in salvage pathway biosynthesis, reduced oxidative stress, inflammation, keratinocyte DNA damage, hyperproliferation cell death zebrafish models skin while all these effects were reversed by supplementation. Similarly,...
Abstract The extracellular matrix (ECM) architecture is composed of supramolecular fibrillar networks that define tissue specific cellular microenvironments. Hemicentins (Hmcn1 and Hmcn2) are ancient very large members (>600 kDa) the fibulin family, whose short known to guide proper morphology functional behavior specialized cell types predominantly in elastic tissues. However, distribution function within microenvironment connective tissues has remained largely unknown. Performing situ...
Abstract Evasion of cell death is a hallmark cancer, and consequently the induction common strategy in cancer treatment. However, molecular mechanisms regulating different types are poorly understood. We have formerly shown that epidermis hypomorphic zebrafish hai1a mutant embryos, pre-neoplastic transformations keratinocytes caused by unrestrained activity type II transmembrane serine protease Matriptase-1 heal spontaneously. This healing driven Matriptase-dependent increased sphingosine...
Aberrantly up-regulated activity of the type II transmembrane protease Matriptase-1 has been associated with development and progression a range epithelial-derived carcinomas, variety signaling pathways can mediate Matriptase-dependent tumorigenic events. During mammalian carcinogenesis, gain Matriptase often results from imbalanced ratios between its cognate inhibitor Hai1. Similarly, in zebrafish, unrestrained due to loss hai1a epidermal pre-neoplasms already during embryogenesis. Here,...