A5001091174- Pancreatic and Hepatic Oncology Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Neuroendocrine Tumor Research Advances
- Global Cancer Incidence and Screening
- Esophageal Cancer Research and Treatment
- Antimicrobial Resistance in Staphylococcus
- Cutaneous Melanoma Detection and Management
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Microbial Inactivation Methods
- Streptococcal Infections and Treatments
- Cardiac tumors and thrombi
- Cell Adhesion Molecules Research
- Cancer survivorship and care
- Hospital Admissions and Outcomes
- Congenital Diaphragmatic Hernia Studies
- Lymphoma Diagnosis and Treatment
- Optical Coherence Tomography Applications
- Esophageal and GI Pathology
- Rabies epidemiology and control
- Lung Cancer Treatments and Mutations
- RNA modifications and cancer
- Pituitary Gland Disorders and Treatments
- Ferroptosis and cancer prognosis
- Wnt/β-catenin signaling in development and cancer
- Developmental Biology and Gene Regulation
University of Nevada, Las Vegas
2018-2025
University of Louisville
2011-2015
Ochsner Medical Center
2011
University of California, Berkeley
2005
University of Southern California
2003-2004
State Street (United States)
2003
Background: Feedback is acknowledged as a necessity for effective learning and performance improvement. However, it has been shown to have variable effects on subsequent performance. This study introduces the "Good, Better, How" (GBH) framework providing receiving feedback in surgical training. Methods: Surgery residents, fellows faculty at single institution completed pre- post-educational intervention surveys, attended GBH educational intervention, participated focus groups. Survey results...
Abstract Background Resection margin status has been shown to impact outcomes for pancreatic adenocarcinoma (PAC), yet it remains unknown whether is a reflection of tumor biology or surgical technique. Methods Two hundred eighty‐three consecutive patients with were identified in prospectively maintained database. Only R0 (n = 207) R1 76) tumors included. Each operative surgeon's first 50 cases excluded control technical inexperience. Univariable and multivariable analyses clinicopathologic...
The prognostic significance of lymphovascular invasion (LVI) in melanoma remains controversial. Clinicopathologic data from a prospective trial patients with were analyzed respect to LVI. Disease-free survival and overall (OS) evaluated by Kaplan-Meier (KM) analysis. Univariate multivariate analyses performed evaluate factors predictive tumor-positive sentinel nodes (SLN) survival. A total 2183 included this analysis; 171 (7.8%) had Median follow-up was 68 months. Factors associated LVI...
The outcome of necrotizing soft tissue infections (NSTI) remains unchanged despite advances in care. Reasons cited are changing patterns causative factors, delays diagnosis, and inadequate antibiotic coverage surgical treatment. To document outcomes NSTI after aggressive management to identify risk factors mortality prolonged hospital stay, we reviewed all our patients with admitted from January 2000 2002. Causative comorbid conditions, site NSTI, physiologic parameters, symptoms, diagnostic...
Abstract Both the Notch and TCR signaling pathways play an important role in T cell development, but links between these are largely unexplored. The adapter protein Numb is a well-characterized inhibitor of also contains phosphotyrosine binding domain, suggesting that could provide link pathways. We explored this possibility by investigating physical interactions among Notch, Numb, apparatus examining consequences mutation on development. found cocluster with at APC contact during Ag-driven...
Irreversible electroporation (IRE) is a promising cell membrane ablative modality for pancreatic cancer. There have been recent concerns regarding local recurrence and the potential use of IRE as debulking (partial ablation) modality. We hypothesize that incomplete ablation leads to early more aggressive biology. created first ever heterotopic murine model by inoculating BALB/c nude mice in hindlimb with subcutaneous injection Panc-1 cells, an immortalized human adenocarcinoma line. Tumors...
There has been conflicting evidence regarding negative effects of blood transfusion in oncology patients. This study was undertaken to determine any specific product after resection hepatic colorectal metastases (CRM). Retrospective review patients undergoing hepatectomy for CRM from 1995 2009 at a single institution performed. Specific attention paid the effect within 30 days operation on overall survival, disease-free survival (DFS), and complications. To mitigate bias introduced by...
Pancreatectomies for malignant and benign diseases are increasingly being performed worldwide. Recent studies, that have evaluated quality of life in pancreatectomy, reported conflicting outcomes.This study was undertaken to analyze the changes by patients with pancreatic cancer undergoing pancreatectomy.Post-hoc analysis a clinical trial examining safety intraoperative autotransfusion during oncologic resections.Perioperative (90-day) complications were graded prospectively using validated...
105 Background: For esophageal cancer patients with dysphagia, symptom relief and maintenance of nutrition remain significant barriers to completion neoadjuvant therapy (NAT). We hypothesized that stenting would allow for successful delivery planned NAT, improvement in quality life (QOL) nutrition. Methods: A multi-institution prospective phase II clinical trial examined dysphagia undergoing NAT. All had a self-expanding polymer stent (ES) placed at initiation Individual chemotherapy RT...
Hepatic mesenchymal hamartomas (HMH) are benign liver lesions that present as cystic, slow growing masses within the first few years of life. Few cases demonstrate placental abnormalities and abnormal levels alpha-fetoprotein (AFP). We report an unusual case a rapidly HMH with associated anomalies elevated AFP. A 2-month-old female born prematurely due to concerning findings presented prenatally-identified mass. Magnetic resonance imaging (MRI) showed marked increase in size mass over...
Abstract Introduction: Oxidative stress secondary to bile acid exposure has been associated with metaplastic degeneration of normal esophageal mucosa into Barrett's Esophagus cells and eventually Esophageal Adenocarcinoma. We have previously reported that the macromolecular response BE this is largely regulated by expression Manganese Superoxide Dismutase (MnSOD). As mitochondrion plays a vital role in MnSOD activation, purpose study was determine location activity within cell after...