Polysaccharides have key biological functions and can be harnessed for therapeutic roles, such as the anticoagulant heparin. Their complexity-e.g., >100 monosaccharides with variety in linkage branching structure-significantly complicates analysis compared to other biopolymers DNA proteins. More, improved, tools been called for, here we demonstrate that solid-state silicon nitride nanopore sensors tuned sensing conditions used reliably detect native polysaccharides enzymatic digestion...

Differences have been found in the cardiopulmonary responses to exercise between young male cigarette somkers and nonsmokers. The present study was undertaken an attempt determine cause of such differences. Since smokers carry a chronically elevated carboxyhemoglobin level (>4%), carbon monoxide inhaled by nonsmokers raise their range seen control group smokers. This maneuver caused development increased oxygen debt with reduced pulmonary diffusing capacity at rest. changes after...

Nanopores are a prominent enabling tool for single-molecule applications such as DNA sequencing, protein profiling, and glycomics, the construction of ionic circuit elements. Silicon nitride (SiNx) is leading scaffold these <100 nm-diameter nanofluidic ion-conducting channels, but frequently challenging surface chemistry remains an obstacle to their use. We functionalized more than 100 SiNx nanopores with different terminations-acidic (Si-R-OH, Si-R-CO2H), basic (Si-R-NH2), nonionizable...

To evaluate the effects of cigarette smoking on some circulatory and ventilatory responses to exercise, a group young male subjects, 18 smokers 14 nonsmokers, was studied. Exercise consisted standard 5-min bicycle ergometer test that achieved mean O 2 uptake 1.44 liters/ min in 5th exercise. There no difference between nonsmokers during subsequent maximal Pulmonary function studies performed two groups revealed normal results for each group. an oxygen debt accumulation among significantly...

A case of atrial parasystole is reported. The parasystolic rhythm was intermittent in character and began each time with an premature beat exhibiting a constant relation to the preceding sinus beat.

Exposure of 10 volunteers to 0.5% CO for 2.5 3.5 min resulted in COHb levels similar that heavy smokers: 3.95 +- 1.87% (SD) as calculated from alveolar air analyses. This a less efficient exercise (greater O/sub 2/ debt equal work) well some barely significant changes, including reduced inspiratory capacity, total lung and resting pulmonary diffusing capacity increased maximum breathing capacity. Same changes were seen smokers compared with nonsmokers.

We investigated the stability, ordering, and composition of mixed self-assembled monolayers (SAMs) on nanoporous gold surfaces formed by dealloying silver–gold leaf. characterized surface features using fast Fourier transform image analysis lead underpotential deposition to quantify changes associated with increased time. SAMs were prepared ferrocenyl alkylthiols alkanethiols. used cyclic voltammetry investigate stability found no differences in pore size. Cyclic investigations...

Abstract Our use of a commercially available monolithic surface enhanced Raman spectroscopy substrate based on metallized arrays nanopillars has been hindered by the structured and variable background spectrum found in as‐supplied substrates. We identify contamination—at minimum from shipping container—as root cause variability observed that our cleaning protocol could enhance spectral performance but also significantly degrade it some cases. These uniquely nanostructured substrates offer...

Background subtraction is a general problem in spectroscopy often addressed with application-specific techniques, or methods that introduce variety of implementation barriers such as having to specify peak-free regions the spectrum. An iterative dual-tree complex wavelet transform-based background method (DTCWT-IA) was recently developed for analysis ultrafast electron diffraction patterns. The designed require minimal user intervention, support streamlined many patterns overlapping peaks...

Drop-casting is frequently used to deliver a sample for surface-enhanced Raman spectroscopy (SERS) and can result in inhomogeneous distribution during solvent evaporation. While soaking provide better analyte homogeneity, it may require more than available. Failure optically analyte-rich substrate locations compromise measurement outcomes. We developed tested 3D printed SERS holders that provided spatial registry of the dried droplet center subsequent optical measurements. found deliberate...

N-Heterocyclic carbenes (NHCs) are an emerging alternative to thiols for the formation of stable self-assembled monolayers (SAMs) on gold. We examined several different species that have been used produce NHC-based gold, namely 1,3-diisopropyl-5-nitrobenzimidazolium iodide, hydrogen carbonate, bis(1,3-diisopropyl-5-nitrobenzimidazolium)gold(I) and 1,3-diisopropyl-5-nitrobenzimidazole-2-ylidene. Contrary expectation, solutions containing first two in tetrahydrofuran dichloromethane caused...

Meeting Abstracts1 May 1973Family Nurse Practitioners for Internists in Primary Care.Robert B. Chevalier, M.D., F.A.C.P., Shirley A. Ross, R.N., Beverly C. Flynn, Ph.D.Robert F.A.C.P.Search more papers by this author, R.N.Search Ph.D.Search authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-78-5-835_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe Family Practitioner Program...

Research Article| December 01 1977 The Physician's Role in Ethical Decisions Robert B. Chevalier Search for other works by this author on: This Site PubMed Google Scholar American Biology Teacher (1977) 39 (9): 542–544. https://doi.org/10.2307/4446081 Views Icon Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Twitter LinkedIn Tools Get Permissions Cite Citation Chevalier; Decisions. 1 1977; doi: Download citation file: Ris (Zotero) Reference Manager EasyBib...