A5009138844- Computational Drug Discovery Methods
- Analytical Chemistry and Chromatography
- Pharmacogenetics and Drug Metabolism
- Lipid Membrane Structure and Behavior
- Synthesis and biological activity
- Microfluidic and Capillary Electrophoresis Applications
- Antibiotics Pharmacokinetics and Efficacy
- Synthesis and Biological Evaluation
- Protein Interaction Studies and Fluorescence Analysis
- Protein purification and stability
- Granular flow and fluidized beds
- Plant biochemistry and biosynthesis
- Analytical Methods in Pharmaceuticals
- Natural product bioactivities and synthesis
- Chemical Synthesis and Analysis
- Antimicrobial Peptides and Activities
Gdańsk Medical University
2020-2023
Screening of physicochemical properties should be considered one the essential steps in drug discovery pipeline. Among available methods, biomimetic chromatography with an immobilized artificial membrane is a powerful tool for simulating interactions between molecule and biological membrane. This study developed quantitative structure-retention relationships model that would predict chromatographically determined affinity xenobiotics to phospholipids, expressed as chromatographic...
Naturally occurring molecules are excellent sources of lead compounds. A series oleanolic acid (OA) derivatives previously synthesized in our laboratory, which show promising antitumor activity, have been analyzed terms lipophilicity evaluation applying chromatographic and computational approaches. Retention data obtained on three reversed-phase liquid chromatography stationary phases (RP-HPLC) immobilized artificial membrane (IAM-HPLC) were compared with methods using chemometric tools such...
The development of screening methods for the estimation physicochemical, biological and pharmacokinetic properties new pharmaceutical agents at early stage drug discovery process is highly desirable. Due to inadequate many candidates are rejected during clinical trials. Among available methods, both chromatographic electrophoretic approaches have a well-established position. This work continuation our research focused on developing micellar electro-kinetic rapid assessment complex...
Sulfonamides are a classic group of chemotherapeutic drugs with broad spectrum pharmacological action, including anticancer activity. In this work, reversed-phase high-performance liquid chromatography and biomimetic were applied to characterize the lipophilicity sulfonamide derivatives proven activities against human colon cancer. Chromatographically determined parameters compared obtained logP, employing various computational approaches. Similarities dissimilarities between experimental...
The development of effective, nontoxic antifungal agents is one the most important challenges for medicinal chemistry. A series isoxazolo [3,4-b]pyridine-3(1H)-one derivatives previously synthesized in our laboratory demonstrated promising properties. main goal this study was to investigate their retention behavior a human serum proteins-high-performance liquid chromatography (HSA-HPLC) system and explore molecular mechanism HSA-isoxazolone interactions using quantitative structure–retention...
The emergence and spread of multiple drug-resistant bacteria strains caused the development new antibiotics to be one most important challenges medicinal chemistry. Despite many efforts, commercial availability peptide-based antimicrobials is still limited. presented study aims explain that immobilized artificial membrane chromatography can support characterization antimicrobial peptides. Consequently, chromatographic experiments three groups related peptide substances: (i) short cationic...
Improved wet granulation techniquesWet is one of the most frequently used processes in pharmaceutical industry to manufacture solid dosage forms.Wet helpful tableting active substances that are not susceptible compression.Despite many years using this method production drugs, prefers use high-shear and fluid bed granulation.Fluidized can be very difficult.Problems related with apparatus, properties processed material, process parameters transfer a larger scale.The undesirable variations...
Sulfonamides are a classic group of chemotherapeutic drugs with broad spectrum pharmacological action also included anticancer activity. In this work, RP-HPLC and IAM-HPLC were applied to characterize the lipophilicity sulfonamide derivatives proven ac-tivities against human colon cancer. Chromatographic determined parameters have been compared logP obtained employing various computational approaches. Similarities dissimilarities between experimental studied using principal component...