A5024050674- Antimicrobial Peptides and Activities
- Lipid Membrane Structure and Behavior
- Biochemical and Structural Characterization
- Analytical Chemistry and Chromatography
- Computational Drug Discovery Methods
- Immune Response and Inflammation
- Chemical Synthesis and Analysis
- Polydiacetylene-based materials and applications
- Analytical Methods in Pharmaceuticals
- Pediatric health and respiratory diseases
- Surfactants and Colloidal Systems
- Synthesis and Characterization of Heterocyclic Compounds
- Chemical Reaction Mechanisms
- Receptor Mechanisms and Signaling
- Synthesis and biological activity
- Forensic Toxicology and Drug Analysis
- RNA and protein synthesis mechanisms
- Spectroscopy and Quantum Chemical Studies
- Machine Learning in Bioinformatics
- Aquaculture disease management and microbiota
- 2D Materials and Applications
- Synthesis and Biological Evaluation
- Antibiotic Use and Resistance
- Click Chemistry and Applications
- Advanced Chemical Sensor Technologies
Gdańsk Medical University
2016-2025
Biomimetic chromatography is a powerful tool used in the pharmaceutical industry to characterize physicochemical properties of molecules during early drug discovery. Some studies have indicated that biomimetic may also be useful for evaluation toxicologically relevant molecules. In this study, we evaluated usefulness approach determining lipophilicity, affinity phospholipids, and bind plasma proteins selected organophosphate pesticides. Quantitative structure–retention relationship (QSRR)...
The increasingly widespread antimicrobial resistance forces the search for new substances capable of fighting infection. Antimicrobial peptides (AMPs) and their synthetic analogs form an extensive group compounds great structural diversity multifunctionality, different modes action, considerable market potential. Some AMPs, in addition to proven antibacterial, antifungal, antiviral activity, also demonstrate anti-inflammatory immunomodulatory capabilities; these are called innate defense...
To get a better insight into the antimicrobial potency of short cationic lipopeptides, 35 new entities were synthesized using solid phase peptide strategy. All newly obtained lipopeptides designed to be positively charged from +1 +4. This was achieved by introducing basic amino acid - lysine lipopeptide structure and had hydrophobic fatty chain attached. Lipopeptides subjected microbiological tests reference strains Gram-negative bacteria: Escherichia coli, Klebsiella pneumoniae, Proteus...
Recent investigations have shown serotonin's stimulatory effect on several types of cancers and carcinoid tumors. Nowadays there has been a significant increase in interest 5-HT7 5-HT5A receptors the context cancer treatment. The possible role 5-HT6R pathogenesis progression glioma remains an interesting relatively unexplored issue. We developed new group long-chain 2-aminoquinazoline sulfonamides as multifunctional serotonin receptor ligands, focused 5-HT6R. chosen was further evaluated for...
Alzheimer’s disease (AD) is a complex neurodegenerative disorder with an unclear etiology. Current treatments, primarily cholinesterase (ChE) inhibitors and N-methyl-D-aspartate receptor (NMDAR) antagonists, offer only symptomatic relief. Drugs targeting one pathological condition have generated limited efficacy. Thus, combining two or more therapeutic interventions into molecule believed to provide higher benefits for the treatment of AD. In this study, we designed, synthesized,...
The thermodynamic properties of micellization for dodecylphosphocholine (DPC), sodium dodecyl sulfate (SDS), and their mixtures were studied using isothermal titration calorimetry. NMR relaxation measurements used to explore molecular mobility the DPC-containing micelles, whereas diffusion taken determine micelle size. DPC/SDS mixed systems reveal a tendency form two kinds micelles in buffered solution at lower temperatures. An increase temperature as well transfer from unbuffered results...
Lipophilicity is a vital physicochemical parameter of molecule, which affects several biological processes such as absorption, tissue distribution, and pharmacokinetic properties. In this study, evaluation lipophilicities series novel fluoroquinolone-Safirinium dye hybrids using chromatographic computational methods presented. Fluoroquinolone-Safirinium have been synthesized new dual-acting hydrophilic antibacterial agents. Reversed phase thin-layer chromatography micellar electrokinetic...
Antimicrobial resistance is a steadily increasing problem and poses serious threat to global public health. Therefore, it highly necessary advance the development of novel antimicrobial compounds semen preservation strategies. The aim this study was evaluate low temperature, antibiotic-free procedure using Androstar Premium (ASP) extender (Minitüb) with lipopeptides. Firstly, seven lipopeptides in two concentrations (1 × minimum inhibitory concentration (MIC)/2 MIC) were tested on their...
1,3,5-triazine derivatives are useful compounds with potential applications in various branches of chemical industry, including pharmaceutical chemistry, cosmetic photochemistry, and organic chemistry. Due to the growing environmental requirements on conducting efficient, economical, safe syntheses, development new methods for synthesizing is highly desirable. In this publication, we present a protocol synthesis using sonochemical approach. as little 5 min, it possible obtain most...
Owing to their excellent antimicrobial activities with a relatively low cost of production, lipopeptides are being intensively investigated as potential alternatives popular antimicrobials. However, critical obstacle for application is high toxicity, hence lot attention has been paid designing new molecules optimal properties. In this study we synthesized the following lipopeptides: C16-KK-NH₂, C16-KεK-NH₂, C16-KKK-NH₂, C16-KRK-NH₂, C16-RR-NH₂, C16-RRR-NH₂, (C10)₂-KKKK-NH₂ and...
Mesostructured ordered silica-based materials are the promising candidates for local drug delivery systems in bone disease due to their uniform pore size and distribution, high surface area which affect excellent adsorption properties, good biocompatibility bioactivity, versatile functionalization so that properties can be controlled. Ordered mesoporous silica (MCM-41 type) was synthesized by a surfactant-assisted sol-gel process using tetraethoxysilane as precursor...
The formation of biofilms on biomaterials causes biofilm-associated infections. Available treatments often fail to fight the microorganisms in biofilm, creating serious risks for patient well-being and life. Due their significant antibiofilm activities, antimicrobial peptides are being intensively investigated this regard. A promising approach is a combination therapy that aims increase efficacy broaden spectrum antibiotics. main goal study was evaluate temporin short lipopeptides...
The lipophilicity of a molecule is well-recognized as crucial physicochemical factor that conditions the biological activity drug candidate. This study was aimed to evaluate isoxazolo[3,4-b]pyridine-3(1H)-ones and their N1-substituted derivatives, which demonstrated pronounced antifungal activities. Several methods, including reversed-phase thin layer chromatography (RP-TLC), reversed phase high-performance liquid (RP-HPLC), micellar electrokinetic (MEKC), were employed. Furthermore,...
The natural antimicrobial cationic peptide protegrin-1 displays a broad spectrum of activity and rapidly kills pathogens by interacting with their cell membrane. We investigated the structure-activity relationships three analogues: IB-367 (RGGLCYCRGRFCVCVGR-NH(2)), BM-1 (RGLCYCRGRFCVCVG-NH(2)) BM-2 (RGLCYRPRFVCVG-NH(2)). Our antifungal studies these peptides showed that was much more active than against Gram-positive bacteria fungi, whereas inactive. fourfold reduced haemolysis relative to...
Abstract I studied the possibility of using amino acid‐based surfactants as emulsifiers at same time preservatives. Fourteen lipopeptides were synthesized employing a solid phase peptide synthesis procedure. All compounds designed to be positively charged from +1 +4 and acylated with fatty acid chain—palmitic miristic. The surface activity obtained was tested semi‐automatic tensiometer calculate parameters describing behavior in air/water interface. Such CMC, tension CMC point ( σ ),...
In this study, we investigated the influence of molecular descriptors cationic lipopeptides on their antimicrobial activity and hemolytic properties. The quantitative structure–activity relationship structure–property models were constructed. antimicrobial, retention data used as dependent variable structural parameters independent ones. obtained results suggest that chromatographic indexes can be employed for prediction antibacterial present nonspecific interaction between erythrocytes...