A5048132931- Drug Solubulity and Delivery Systems
- Analytical Chemistry and Chromatography
- Analytical Methods in Pharmaceuticals
- Antimicrobial Peptides and Activities
- Pharmaceutical studies and practices
- Crystallization and Solubility Studies
- Material Dynamics and Properties
- Advanced Drug Delivery Systems
- Computational Drug Discovery Methods
- Bone Tissue Engineering Materials
- Mesoporous Materials and Catalysis
- Lipid Membrane Structure and Behavior
- Thermodynamic properties of mixtures
- Protein purification and stability
- Liquid Crystal Research Advancements
- Pharmacological Effects and Toxicity Studies
- Antibiotics Pharmacokinetics and Efficacy
- Biochemical and Structural Characterization
- Thermal and Kinetic Analysis
- Microencapsulation and Drying Processes
- Advanced Chemical Sensor Technologies
- Pharmacogenetics and Drug Metabolism
- Immune Response and Inflammation
- Aerogels and thermal insulation
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
Gdańsk Medical University
2016-2025
Biomimetic chromatography is a powerful tool used in the pharmaceutical industry to characterize physicochemical properties of molecules during early drug discovery. Some studies have indicated that biomimetic may also be useful for evaluation toxicologically relevant molecules. In this study, we evaluated usefulness approach determining lipophilicity, affinity phospholipids, and bind plasma proteins selected organophosphate pesticides. Quantitative structure–retention relationship (QSRR)...
Dielectric spectroscopy (DS) was used to investigate the relaxation dynamics of supercooled and glassy ibuprofen at various isobaric isothermal conditions (pressure up 1750 MPa). The ambient pressure data are in good agreement with that reported previously literature. Our high measurements revealed validity temperature−pressure superpositioning (TPS) for α-peak. We also found value fragility index decreases compression from m = 87 ± 2 atmospheric 72.5 3.5 (p 920 drop observed our experiment...
Glibenclamide (GCM) is an oral hypoglycemic agent of the sulfonylurea group used in treatment non-insulin-dependent diabetes. Crystalline GCM characterized by low bioavailability, which attributed to its poor dissolution properties. It prompted us prepare this drug amorphous form as a means enhance characteristics. Two different methods were convert crystalline into glassy form: quench-cooling melt and cryogenic milling. To monitor solid-state properties samples, X-ray powder diffraction...
Arbidol hydrochloride is an antiviral product widely used in Russia and China for the treatment of, among other diseases, influenza. In recent years, it has turned out to be highly effective against COVID-19. However, there little knowledge about its physicochemical properties behavior presence of various pharmaceutical excipients, which could useful development new preparations by increasing solubility bioavailability. For this reason, binary mixtures composed arbidol selected excipients...
This study for the first time investigates physicochemical properties of amorphous indapamide drug (IND), which is a known diuretic agent commonly used in treatment hypertension. The solid-state vitrified, cryomilled and ball-milled IND samples were analyzed using X-ray powder diffraction (XRD), mass spectrometry, nuclear magnetic resonance (NMR), infrared spectroscopy (FT-IR), differential scanning calorimetry (DSC) broadband dielectric (BDS). These analytical techniques enabled us (i) to...
The purpose of this paper is to examine the role molecular mobility in recrystallization process from amorphous state anticholesterol drug ezetimibe. Both dynamics and crystallization kinetics have been studied using various experimental techniques, such as broadband dielectric spectroscopy (BDS), differential scanning calorimetry (DSC), X-ray diffraction (XRD). Our investigations shown that ezetimibe easily recrystallizes disordered state, both below above its glass transition temperature...
To get a better insight into the antimicrobial potency of short cationic lipopeptides, 35 new entities were synthesized using solid phase peptide strategy. All newly obtained lipopeptides designed to be positively charged from +1 +4. This was achieved by introducing basic amino acid - lysine lipopeptide structure and had hydrophobic fatty chain attached. Lipopeptides subjected microbiological tests reference strains Gram-negative bacteria: Escherichia coli, Klebsiella pneumoniae, Proteus...
Acne vulgaris is one of the most common skin diseases, and its development closely linked to overgrowth bacterium Cutibacterium acnes. More than half strains this are resistant antibiotics, which has prompted scientists look for alternatives, such as antibacterial peptides, that can replace traditional drugs. Due antioxidant properties, ascorbic acid may be a promising ally in treatment acne. The aim our study was evaluate effect peptide (KWK)2-KWWW-NH2(P5) presence (AA) derivative...
In this paper the molecular dynamics of a common local-anesthetic drug, lidocaine hydrochloride (LD-HCl), and its water mixtures were investigated. By means broadband dielectric spectroscopy calorimetric measurements it was shown that even small addition causes significant effect on relaxation analyzed protic ionic liquid. Apart from two well-resolved relaxations (σ- γ-processes) β-mode, identified as JG-process, observed for anhydrous LD-HCl, new peak (υ) is visible in spectra aqueous drug....
To investigate the effect of cryogrinding on chemical stability diuretic agent furosemide and its mixtures with selected excipients.Furosemide was ground at liquid nitrogen temperature for 30, 60, 120 180 min. Mixtures furosemide-PVP furosemide-inulin (1:1) were milled under cryogenic conditions. Materials analyzed by XRD, UPLC, MS NMR.Upon increasing milling time, a significant build-up an unidentified impurity 1, probably main degradation product, noticed. Cogrinding PVP inulin worsened...
In this paper, a novel approach to determine stable concentration in API-polymer systems is presented. As model, binary amorphous mixtures flutamide (FL) drug with copolymer Kollidon VA64 (PVP/VA) have been used. It worthwhile note that finding an effective method achieve goal matter of great importance because physical stability the pharmaceuticals key issue investigated worldwide. Due fact molecular dynamics was found be crucial factor affecting disordered pharmaceuticals, we examined it...
Lipophilicity is a vital physicochemical parameter of molecule, which affects several biological processes such as absorption, tissue distribution, and pharmacokinetic properties. In this study, evaluation lipophilicities series novel fluoroquinolone-Safirinium dye hybrids using chromatographic computational methods presented. Fluoroquinolone-Safirinium have been synthesized new dual-acting hydrophilic antibacterial agents. Reversed phase thin-layer chromatography micellar electrokinetic...
The aim of this article is to examine the crystallization tendencies three chemically related amorphous anti-inflammatory agents, etoricoxib, celecoxib, and rofecoxib. Since molecular mobility considered as one factors affecting behavior a given material, broadband dielectric spectroscopy was used gain insight into dynamics selected active pharmaceutical ingredients. Interestingly, our experiments did not reveal any significant differences in their relaxation either supercooled liquid or...