A5101432028- Plant Molecular Biology Research
- Plant Stress Responses and Tolerance
- Plant Gene Expression Analysis
- Photosynthetic Processes and Mechanisms
- Bee Products Chemical Analysis
- Plant nutrient uptake and metabolism
- Dermatology and Skin Diseases
- Sirtuins and Resveratrol in Medicine
- Light effects on plants
- Autophagy in Disease and Therapy
- Plant Reproductive Biology
- Skin Protection and Aging
- Tea Polyphenols and Effects
- Antimicrobial Peptides and Activities
- Heme Oxygenase-1 and Carbon Monoxide
- Phytochemicals and Antioxidant Activities
- Plant tissue culture and regeneration
- RNA and protein synthesis mechanisms
- Biotin and Related Studies
- Tryptophan and brain disorders
- Sphingolipid Metabolism and Signaling
- bioluminescence and chemiluminescence research
- Traditional Chinese Medicine Analysis
- Plant responses to water stress
- Natural product bioactivities and synthesis
Konkuk University
2018-2025
Gyeongsang National University
2018-2020
Komipharm International (South Korea)
2019
Chungnam National University
2015-2018
Switching from repressed to active status in chromatin regulation is part of the critical responses that plants deploy survive an ever-changing environment. We previously reported HOS15, a WD40-repeat protein, involved histone deacetylation and cold tolerance Arabidopsis However, it remained unknown how HOS15 regulates responsive genes affect tolerance. Here, we show interacts with deacetylase 2C (HD2C) both proteins together associate promoters cold-responsive COR genes, COR15A COR47 Cold...
DddA-derived cytosine base editors (DdCBEs) and transcription activator-like effector (TALE)-linked deaminases (TALEDs) catalyze targeted editing of mitochondrial DNA (mtDNA) in eukaryotic cells, a method useful for modeling genetic disorders developing novel therapeutic modalities. Here, we report that A-to-G-editing TALEDs but not C-to-T-editing DdCBEs induce tens thousands transcriptome-wide off-target edits human cells. To avoid these unwanted RNA edits, engineered the substrate-binding...
Drought is one of the most critical environmental stresses limiting plant growth and crop productivity. The synthesis signaling abscisic acid (ABA), a key phytohormone in drought stress response, under photoperiodic control. GIGANTEA (GI), regulator photoperiod-dependent flowering circadian rhythm, also involved pathways for various abiotic stresses. In this study, we isolated ENHANCED EM LEVEL (EEL)/basic Leu zipper 12, transcription factor ABA signal responses, as GI interactor Arabidopsis...
Drought stress adversely affects plant growth and development significantly reduces crop productivity yields. The phytohormone abscisic acid (ABA) rapidly accumulates in response to drought mediates the expression of stress-responsive genes that help survive dehydration. protein POWERDRESS (PWR), which interacts with HISTONE DEACETYLASE 9 (HDA9), has been identified as a critical component regulating development, flowering time, floral determinacy, leaf senescence. However, role function PWR...
Ultraviolet (UV) irradiation is a relevant environment factor to induce cellular senescence and photoaging. Both autophagy- silent information regulator T1 (SIRT1)-dependent pathways are critical processes of not only maintaining normal functions, but also protecting in skin exposed UV irradiation. In the present studies, we investigated whether modulation autophagy induction using novel synthetic SIRT1 activator, heptasodium hexacarboxymethyl dipeptide-12 (named as Aquatide), suppresses UVB...
Cold stress is a major environmental that severely affects plant growth and crop productivity. Arabidopsis (Arabidopsis thaliana) HIGH EXPRESSION OF OSMOTICALLY RESPONSIVE GENE15 (HOS15) substrate receptor of the CULLIN4-based CLR4 ubiquitin E3 ligase complex, which epigenetically regulates cold tolerance by degrading HISTONE DEACETYLASE2C (HD2C) to switch from repressive permissive chromatin structure in response stress. In this study, we characterized HOS15-binding protein, POWERDRESS...
Abstract The plant hormone abscisic acid (ABA) is an important regulator of growth and development plays a crucial role in both biotic abiotic stress responses. ABA modulates flowering time, but the precise molecular mechanism remains poorly understood. Here we report that INSENSITIVE 2 (ABI2) only phosphatase from ABA-signaling core positively regulates transition to Arabidopsis. Loss-of-function abi2-2 mutant shows significantly delayed under long day short conditions. Expression floral...
The circadian clock in plants is crucial for regulating stress responses, including cold tolerance. Cold induces the expression of C-REPEAT BINDING FACTOR (CBF) transcription factors, which activate COLD-REGULATED (COR) genes to mitigate cold-induced damage. Previously, we identified that HIGH EXPRESSION OF OSMOTICALLY RESPONSIVE GENE15 (HOS15)-HISTONE DEACETYLASE 2C (HD2C) complex regulates tolerance by modulating histone deacetylation on COR genes. Our research reports oscillator GIGNATEA...
Abstract The precise timing of flowering in adverse environments is critical for plants to secure reproductive success. We report a mechanism Arabidopsis (Arabidopsis thaliana) controlling the time by which S-acylation-dependent nuclear import protein SALT OVERLY SENSITIVE3/CALCINEURIN B-LIKE4 (SOS3/CBL4), Ca2+-signaling intermediary plant response salinity, results selective stabilization regulator GIGANTEA inside nucleus under salt stress, while degradation cytosol releases kinase SOS2...
Significance Immune responses protect organisms against biotic challenges but can also produce deleterious effects, such as inflammation and necrosis. This growth-defense trade-off necessitates fine control of immune responses, including the activation defense gene expression. The transcriptional coactivator NPR1 is a key regulatory hub in plant cells. Surprisingly, full NPR1-activated genes requires proteasome-mediated degradation induced by CUL3-based E3 ubiquitin ligase complex. Our work...
Multiple endogenous and environmental signals regulate the intricate highly complex processes driving leaf senescence in plants. A number of genes have been identified a variety plant species, including Arabidopsis, which influence senescence. Previously, we shown that HOS15 is multifunctional protein regulates several physiological processes, growth development under adverse conditions. has also reported to form chromatin remodeling with PWR HDA9 structure numerous genes. However, unlike...
Background: Pentasodium tetracarboxymethyl palmitoyl dipeptide-12 (PTPD-12), a newly-synthesized peptide, enhances the autophagy activity, ultimately managing inflammation.Objective: To determine effect of new moisturizer containing PTPD-12 as treatment mild-to-moderate atopic dermatitis (AD).Methods: In this double-blind, randomized, placebo-controlled trial, 43 patients with AD were randomly assigned to either or control groups. Evaluations performed at baseline, week 2, and 4, including...
Pollution-induced skin damage results in oxidative stress; cellular toxicity; inflammation; and, ultimately, premature aging. Previous studies suggest that the activation of autophagy can protect oxidation-induced and aging-like changes skin. In order to develop new anti-pollution ingredients, this study screened various kinds natural extracts measure their efficacy cultured dermal fibroblast. The stimulation flux by selected was further confirmed both expression proteins associated with...
Cold stress is a major environmental constraint that restrains plant growth and productivity. To cope with cold stress, plants must be able to perceive signal regulate the expression of cold-regulated (COR) genes. In our recent study, we showed Arabidopsis HIGH EXPRESSION OF OSMOTICALLY RESPONSIVE GENE 15 (HOS15) acts as substrate receptor for CULLIN4-based ubiquitin E3 ligase complex promote cold-induced histone deacetylase 2 C (HD2C) degradation allows activation COR Additionally, found...
The plant hormone, abscisic acid (ABA), is not only important for promoting abiotic stress responses but also plays a versatile and crucial role in immunity. pathogen infection-induced dynamic accumulation of ABA mediates the degradation non-expresser PR genes 1 (NPR1) through CUL3NPR3NPR4 proteasome pathway. However, functional significance NPR1 by other E3 ligases response to remains unclear. Here, we report that induced transcriptionally npr1-1 mutation results insensitivity during seed...
Arabidopsis HOS15/PWR/HDA9 repressor complex, which is similar to the TBL1/NcoR1/HDAC complex in animals, plays a well-known role epigenetic regulation. PWR and HDA9 have been reported interact with each other modulate flowering time by repressing AGL19 expression, whereas HOS15 HDA9, together photoperiodic evening regulate through repression of GI transcription. However, core as functional unit regulation yet be explored. In this study, we that loss-of-function hos15-2/pwr/hda9 triple...
Summary Background Recently, potential roles of autophagy in skin homeostasis received many interests. But, little has been reported for the antiaging effects activator. Objective With newly synthesized activator, heptasodium hexacarboxymethyl dipeptide‐12 (Aquatide™) vitro and clinical efficacy topical activator as an cosmeceutical ingredient was evaluated. Methods Antioxidant effect Aquatide™ evaluated by radical scavenging assay. In assessed measuring cytotoxicity hydrogen peroxide...
Based on the potential beneficial effects of growth hormone releasing peptide (GHRP)-6 muscle functions, a newly synthesized GHRP-6-biotin conjugate was tested cultured myoblast cells. Increased expression myogenic marker proteins observed in conjugate-treated Additionally, increased levels insulin-like factor-1 and collagen type I were observed. Furthermore, cells showed metabolic activity, as indicated by concentrations energy metabolites, such ATP lactate, enzymatic activity lactate...
ABSTRACT The precise timing of flowering in adverse environments is critical for plants to secure reproductive success. We report a novel mechanism controlling the time by which palmitoylation-dependent nuclear import protein SOS3/CBL4, Ca 2+ -signaling intermediary plant response salinity, results selective stabilization regulator GIGANTEA inside nucleus under salt stress, while degradation cytosol releases kinase SOS2 achieve tolerance. S -acylation SOS3 was its localization and promotion...