A5074764833- Dermatology and Skin Diseases
- Advancements in Transdermal Drug Delivery
- Sphingolipid Metabolism and Signaling
- Contact Dermatitis and Allergies
- Polysaccharides and Plant Cell Walls
- Allergic Rhinitis and Sensitization
- Skin Protection and Aging
- Cannabis and Cannabinoid Research
- Transgenic Plants and Applications
- Neuroendocrine regulation and behavior
- Crystallization and Solubility Studies
- Surfactants and Colloidal Systems
- Stress Responses and Cortisol
- Lipid Membrane Structure and Behavior
- Cellular transport and secretion
- Endoplasmic Reticulum Stress and Disease
- Tea Polyphenols and Effects
- Toxin Mechanisms and Immunotoxins
- Pesticide and Herbicide Environmental Studies
- Erythrocyte Function and Pathophysiology
- Circadian rhythm and melatonin
- Polysaccharides Composition and Applications
- Tryptophan and brain disorders
- Sirtuins and Resveratrol in Medicine
- Autophagy in Disease and Therapy
NeoPhotonics (United States)
2011-2017
Komipharm International (South Korea)
2007-2011
Korea Research Institute of Bioscience and Biotechnology
2005-2008
Yonsei University
2007
Ultraviolet (UV) irradiation is a relevant environment factor to induce cellular senescence and photoaging. Both autophagy- silent information regulator T1 (SIRT1)-dependent pathways are critical processes of not only maintaining normal functions, but also protecting in skin exposed UV irradiation. In the present studies, we investigated whether modulation autophagy induction using novel synthetic SIRT1 activator, heptasodium hexacarboxymethyl dipeptide-12 (named as Aquatide), suppresses UVB...
Several studies have been performed to evaluate the efficacy of dietary n-3 fatty acid for patients with renal dysfunction. While about 40% 80% end-stage disease (ESRD) complain pruritus and xerosis, there are few reports on effects topical these symptoms.In order investigate possible beneficial acid, oils extracted from chia (Salvia hispanica) seed were formulated into products, which measured.Five healthy volunteers having xerotic symptoms 5 caused by either ESRD or diabetes involved in...
Although several agents have been identified to provide therapeutic benefits in Huntington Disease (HD), the number of conventionally used treatments remains limited and only symptomatic. Thus, it is plausible that need identify new targets for development alternative more effective becoming increasingly urgent. Recently, sphingosine-1-phosphate axis has reported be a valid potential novel molecular target therapy HD. Modulation aberrant metabolism S1P HD proved exert neuroprotective action...
Atopic dermatitis (AD) is a chronic inflammatory skin disease that commonly begins in childhood. K6PC-9p (N-(Ethyl dihydrogenphosphate)-2-hexyl-3-oxo-decanamide) synthetic ceramide derivative of PC-9S (N-Ethanol-2-mirystyl-3-oxo-staramide), which was known to be effective atopic patients. In this study, we examined the effect topical application on inflammation and AD-like lesions mouse models. dose-dependently inhibited phorbol ester-induced increase ear thickness BALB/c mice. Moreover,...
The management of sensitive skin, which affects over 60% the general population, has been a long-standing challenge for both patients and clinicians. Because defective epidermal permeability barrier is one clinical features barrier-enhancing products could be an optimal regimen skin. In present study, we evaluated efficacy safety two products, i.e., Atopalm ® Multi-Lamellar Emulsion (MLE) Cream Physiogel Intensive 60 with aged 22–40 years old, were randomly assigned to group treated MLE...
Autism, a childhood behavioral disorder, belongs to large suite of diseases, collectively referred as autism spectrum disorders (ASD). Though multifactorial in etiology, approximately 10% ASD are associated with atopic dermatitis (AD). Moreover, prevalence increases further AD severity worsens, though these share no common causative mutations. We assessed here the link between two standard, valproic acid mouse model ASD. In prior studies, there was evidence skin involvement, but we...
Ceramide is an important constituent of stratum corneum lipids, which act as both physical barriers and signal modulators. We synthesized several ceramide derivatives investigated their effects on keratinocyte differentiation. RT-PCR Western blotting showed that the novel synthetic K6PC-4 (N-ethanol-2-hexyl-3-hydroxy-decanamide), K6PC-5, (N-ethanol-3-oxo-2-tetradecyl/hexadecyl-octadecanamide/eicosanamide)and K6PC-9 [N-(1,3-dihydroxypropyl)-2-hexyl-3-oxo-decanamide] markedly increased keratin...
Sphingosine-1-phosphate (S1P), which is formed by phosphorylation of sphingosine through a process catalysed kinase (SK), multifunctional mediator variety cellular responses including proliferation, differentiation, motility, and survival. K6PC-5, was recently synthesized as novel SK activator, expected to increase S1P levels. Indeed studies have already demonstrated that K6PC-5 exhibits anti-aging effects on intrinsic aged murine skin increasing fibroblasts, collagen synthesis, dermal...
Recently, cannabis, or its major constituent cannabidiol (CBD), has emerged as an attractive cosmetic ingredient. Initiated a basic investigation of the physiological roles cannabinoid receptors and their endogenous ligands, endocannabinoids’ diverse potential benefits have been proposed for using receptor modulating compounds in skin health. Improvement barrier functions, alleviating inflammatory responses, relief itching sensations are some commonly expected therapeutic benefits, which...
Recently, we reported on the anti-ageing effects of K6PC-5. This compound induced keratinocyte differentiation and fibroblast proliferation by increasing sphingosine-1 phosphate synthesis. We performed this study to confirm new synthetic products (the K6EAA series) derived from K6PC-5 through an amino group induction. Cellular responses such as differentiation, calcium mobilization were investigated using cultured human keratinocytes fibroblasts. Also, measured expressions collagen mRNA...
Ceramides, a class of sphingolipids containing backbone sphingoid base, are the most important and effective structural component for formation epidermal permeability barrier. While ceramides comprise approximately 50% lipid content by mass, is substantially decreased in certain inflammatory skin diseases, such as atopic dermatitis (AD), causing improper barrier function. It widely accepted that endocannabinoid system (ECS) can modulate number biological responses central nerve system, prior...
Background: Topical steroid treatment induces diverse local Wand systemic adverse effects.Several approaches have been tried to reduce the steroid-induced effects.Simultaneous application of physiological lipid mixture is also suggested.Objective: Novel vehicles for topical glucocorticoids formulation were evaluated efficacy reducing side-effects and drug delivery properties desonide, a low potency steroid.Methods: Transcutaneous permeation skin residual amount desonide measured using Franz...
GPR119 is a novel cannabinoid receptor that primarily expressed in the pancreas and gastrointestinal tract has beneficial effects on glucose homeostasis exerted through stimulation of GLP-1 secretion, as demonstrated rodent brain. also important anti-inflammatory chronic inflammatory diseases, including type 1 2 diabetes, asthma, psoriasis, neurodegenerative disorders. Recently, there been increasing interest effect gut microbiota both However, few studies have examined how microbes affect...
Sphingosine kinase (SPHK) has a central role to control cell death and proliferation, which is suggested as sphingolipid rheostat by regulating the levels between ceramide sphingosine 1-phosphate (S1P). Therefore, physiological regulators of SPHK will be good candidate develop new targeted drug. For this purpose, series synthetic pseudoceramides were tested assay either cell-based or cell-free system. K10PC-5 strongly inhibited SPHK, while K6PC-5 activated in Specifically, under co-treatment...