A5040453440- SARS-CoV-2 and COVID-19 Research
- Gut microbiota and health
- Microtubule and mitosis dynamics
- Tryptophan and brain disorders
- Influenza Virus Research Studies
- SARS-CoV-2 detection and testing
- Cancer Research and Treatments
- Glycosylation and Glycoproteins Research
- Clostridium difficile and Clostridium perfringens research
- Cancer-related Molecular Pathways
- Computational Drug Discovery Methods
- Monoclonal and Polyclonal Antibodies Research
- COVID-19 Clinical Research Studies
- DNA Repair Mechanisms
Simcere Pharmaceutical (China)
2023-2025
Tsinghua University
2025
Hebei Medical University
2024
The persistent pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome 2 (SARS-CoV-2) and its variants accentuates the great demand for developing effective therapeutic agents. Here, we report development an orally bioavailable SARS-CoV-2 3C-like protease (3CL
ABSTRACT Simnotrelvir is an oral small-molecule antiviral agent targeting the 3C-like protease (3CL pro ) of SARS-CoV-2, proven effective against Delta variant with favorable pharmacokinetics and safety in preclinical study. In this study, we further evaluated efficacy simnotrelvir a range emerging Omicron variants, including BA.1, BA.4, BA.5, CH.1.1, XBB.1.5, XBB.1.16, EG.5, JN.1. vitro assays Vero E6 cells confirmed that exhibited robust activity across these comparable to Food Drug...
Epidemiological studies have revealed an inverse relationship between the incidence of Alzheimer’s disease (AD) and various cancers, including colorectal cancer (CRC). We aimed to determine whether CRC is reduced in AD-like mice gut microbiota confers resistance tumorigenesis through inducing inflammatory tolerance using 16S ribosomal RNA gene sequencing fecal transplantation (FMT). experienced a significantly decreased induced by azoxymethane–dextran sodium sulfate as evidenced suppressed...
Abstract Background: Although advances treatments have significantly improved the survival of patients with gastrointestinal cancer in recent decades, there is still an unmet medical need for more effective treatments. A promising strategy use bispecific antibodies that recruit T cells to kill by simultaneously binding CD3 on and tumor associated antigens. CD3-based cell engagers are highly potent therapeutic molecules cytotoxicity activities. But high CRS risk exhaustion has been observed...
Abstract The repair of DNA double strand break (DSB) is crucial for genome stability and cell survival. There are three main DSB pathways: homologous recombination (HR), non-homologous end joining (NHEJ) microhomology-mediated (MMEJ). HR a high-fidelity, error-free pathway, the dysfunction confers instability leads to tumorigenesis. deficiency especially prevalent in gynecologic tumors, sharing about 10% population all tumor patients. In situation deficiency, MMEJ, which polymerase theta...