A5100648846- Psychosocial Factors Impacting Youth
- Metabolism, Diabetes, and Cancer
- Alzheimer's disease research and treatments
- Education and Learning Interventions
- Diet and metabolism studies
- Neuroscience and Neuropharmacology Research
- Consumer Perception and Purchasing Behavior
- Mitochondrial Function and Pathology
- Air Quality and Health Impacts
- Diverse Approaches in Healthcare and Education Studies
- Pancreatic function and diabetes
- Tryptophan and brain disorders
- Metabolomics and Mass Spectrometry Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Statistical Methods and Bayesian Inference
- Statistical Methods and Applications
- Natural Antidiabetic Agents Studies
- Neurogenesis and neuroplasticity mechanisms
- Diverse Topics in Contemporary Research
- Educational Systems and Policies
- Adipokines, Inflammation, and Metabolic Diseases
- Olfactory and Sensory Function Studies
- Apelin-related biomedical research
- Ginseng Biological Effects and Applications
- Amyotrophic Lateral Sclerosis Research
Yonsei University
2015-2025
Kangwon National University
2024
University of Cambridge
2020-2023
National Institute of Environmental Research
2022
Wellcome/MRC Cambridge Stem Cell Institute
2020
Institute of Behavioral Sciences
2016
Keimyung University
2010
National Veterinary Research and Quarantine Service
2010
Abstract Metformin, a primary anti-diabetic medication, has been anticipated to provide benefits for Alzheimer’s disease (AD), also known as “type 3 diabetes”. Nevertheless, some studies have demonstrated that metformin may trigger AD pathology and even elevate risk in humans. Despite this, limited research elucidated the behavioral outcomes of treatment, which would hold significant translational value. Thus, we aimed perform thorough on prolonged administration mice: We administered (300...
Abstract Metformin reduces insulin resistance, which constitutes a pathophysiological connection of diabetes with Alzheimer’s disease (AD), but the evidence metformin on AD development was still insufficient and conflicting. We investigated risk in patients newly diagnosed type 2 DM treated metformin. This retrospective, observational, nested case–control study included obtained from Korean National Health Insurance Service cohort (2002–2017). Among 70,499 dementia-free patients, 1675 cases...
Particulate matter (PM) exposure is related to an increased risk of sporadic Alzheimer's disease (AD), the pathogenesis which explained by chronic neurometabolic disturbance. Therefore, PM-induced alterations in neurometabolism might herald AD. We aimed identify brain region-specific changes metabolic pathways associated with ultrafine particle (UFP) and determine whether such are linked susceptibility constructed UFP chambers generated pyrolysis method, produces no toxic oxidized...
Discovery of biomarkers in peripheral blood is a crucial step toward the early diagnosis and repetitive monitoring treatment response for Alzheimer's disease (AD). Metabolomics promising technology that can identify unbiased biomarkers. To ex
Reliable and reproducible assessment of animal learning behavior is a central aim basic translational neuroscience research. Recent developments in automated operant chamber technology have led to the possibility universal standard protocols, addition increased potential, reliability accuracy. However, impact regional national differences supplies available reinforcers this system on behavioural performance inter-laboratory variability an unknown at present uncontrolled variable. Therefore,...
Abstract Objective Plasma clusterin, a promising biomarker of Alzheimer disease (AD), has been associated with diabetes mellitus (DM). However, clusterin not investigated considering relationship both DM and AD. In this study, we aimed to investigate the individual interactive relationships plasma levels diseases. Design Cross-sectional observation study. Methods We classified participants by severity cognitive (normal cognition, mild impairment [MCI], AD) metabolic (healthy control,...
<b><i>Objective:</i></b> Donepezil, a widely prescribed drug for Alzheimer's disease (AD), is now considered to have multimodal actions beyond cholinesterase inhibition. We aimed see whether donepezil enhances mitochondrial biogenesis and relevant signaling pathways since dysfunction key feature of the hypometabolic AD brain. <b><i>Methods:</i></b> As metabolic gauge, AMP-activated protein kinase (AMPK) was investigated as tentative mediator...
Particulate matter (PM), released into the air by a variety of natural and human activities, is key indicator pollution. Although PM known as extensive health hazard to affect illness, few studies have specifically investigated effects PM10 exposure on schizophrenic development. In present study, we aimed investigate impact MK-801, N-methyl-D-aspartate (NMDA) receptor antagonist, induced schizophrenia-like behaviors in C57BL/6 mouse. Preadolescent mice were exposed 3.2 mg/m3 concentration...
Conventional methods for organotypic hippocampal tissue slice culture (OHSC) have shown several disadvantages or limitations regarding age of animals used, duration and difficulty using neurodegenerative models. Therefore, we tried to establish OHSC from old 3xTg-Alzheimer's disease (AD) mice longer period (over 4 weeks) validate utility this system as a valid platform translational neuroscience AD. was performed with 3xTg-AD (12-14 months), wild type months) young (2-4 serum-free medium...
Abstract Background Blood adiponectin and leptin are adipokines that emerged as potential biomarkers for predicting Alzheimer’s disease (AD) owing to their strong connection with obesity. Although obesity affects the relation between beta-amyloid (Aβ) aggregation cognitive decline, longitudinal interactive effect of Aβ on cognition brain structures in humans remains unexplored. Hence, we investigated whether plasma levels associated future decline cortical thinning across conditions (Aβ [+]...
Reduced glucose metabolism has been implicated as a pathophysiology of depressive disorder. Normalization such impaired neurometabolism related to the therapeutic actions antidepressant medication. However, molecular mechanism underlying neurometabolic antidepressants not fully understood. Given that AMP-activated protein kinase (AMPK) is master switch for energy homeostasis, we aimed determine whether selective serotonin reuptake inhibitor paroxetine enhances by activating AMPK in...
Abstract Perseveration and apathy are two of the most common behavioural psychological symptoms dementia (BPSDs) in amyotrophic lateral sclerosis–frontotemporal (ALS–FTD). Availability a validated behaviourally characterised animal model is crucial for translational research into BPSD FTD context. We evaluated male TDP-43 Q331K mouse, an ALS–FTD with human-equivalent mutation (TDP-43 ) knocked endogenous Tardbp gene. utilised panel tasks delivered using rodent touchscreen apparatus,...