A5062362542- Influenza Virus Research Studies
- Vaccine Coverage and Hesitancy
- Bacterial Infections and Vaccines
- Patient Satisfaction in Healthcare
- Pneumonia and Respiratory Infections
- Pregnancy and preeclampsia studies
- Pregnancy and Medication Impact
- Infectious Encephalopathies and Encephalitis
- Hepatitis B Virus Studies
- Healthcare Policy and Management
- Urinary Tract Infections Management
- Assisted Reproductive Technology and Twin Pregnancy
- Reproductive System and Pregnancy
- Respiratory viral infections research
- Central Venous Catheters and Hemodialysis
- Pharmacovigilance and Adverse Drug Reactions
- Birth, Development, and Health
- Health Systems, Economic Evaluations, Quality of Life
- SARS-CoV-2 and COVID-19 Research
- Emergency and Acute Care Studies
- Healthcare cost, quality, practices
- Prostate Cancer Treatment and Research
- Bone health and treatments
- Cervical Cancer and HPV Research
- Fibromyalgia and Chronic Fatigue Syndrome Research
RTI Health Solutions
2018-2025
Harvard Pilgrim Health Care
2014-2020
Harvard University
2014-2020
Research Network (United States)
2018
National Institutes of Health
2018
HealthPartners
2018
Yale University
2018
Kaiser Permanente Center for Health Research
2018
Kaiser Permanente
2018
Marshfield Clinic
2018
Preamble1.1.Need for developing case definitions and guidelines data collection, analysis, presentation stillbirth as an adverse event following immunization during pregnancy One of the most common outcomes is death fetus.Fetal has a great number different ଝ Disclaimer: The findings, opinions assertions contained in this consensus document are those individual scientific professional members working group.They do not necessarily represent official positions each participant's...
Chronic pain has major clinical and social consequences. Few studies have examined any variation in the extent of impairment on quality life work productivity by site type chronic pain.The objective our study is to examine adverse impacts physical psychological health productivity.Our community-population was based a phone-interview adults with pain, residing Olmsted County, MN. groups were categorized into abdominal back joint multisite neuropathic or no pain. We used standardized...
BACKGROUND: Health care–associated infections (HAIs) are harmful and costly can result in substantial morbidity for hospitalized children; however, little is known about national trends HAIs neonatal pediatric populations. Our objective was to determine the incidence of among a large sample hospitals United States caring critically ill children from 2007 2012. METHODS: In this cohort study, we included NICUs PICUs located reporting data Centers Disease Control Prevention’s National...
The Postlicensure Rapid Immunization Safety Monitoring Program, the vaccination safety monitoring component of US Food and Drug Administration's Mini-Sentinel project, is currently largest cohort in general population for vaccine surveillance. We developed a study design selection framework to provide roadmap description methods that may be utilized evaluate potential associations between vaccines health outcomes interest Program other systems using administrative data. strengths weaknesses...
ABSTRACT Purpose We conducted weekly surveillance for pre‐specified adverse events following receipt of the 2012–2013 influenza vaccines in Vaccine Safety Datalink (VSD). Methods For each outcome, risk intervals (i.e., period after vaccination with a potentially increased risk) were defined on basis biologic plausibility and prior literature. Seizures inactivated vaccine (IIV) monitored children three age groups (6–23 months, 24–59 5–17 years) using self‐controlled interval design. also...
Article| March 01 2018 Infant Hospitalizations and Mortality After Maternal Vaccination Lakshmi Sukumaran, MD; MD aImmunization Safety Office, Centers for Disease Control Prevention, Atlanta, Georgia; Address correspondence to MD, MPH, Immunization 1600 Clifton Rd NE, MS D-26, GA 30333. E-mail: lsukumaran@cdc.gov Search other works by this author on: This Site PubMed Google Scholar Natalie L. McCarthy, MPH; MPH Elyse O. Kharbanda, bHealthPartners Institute, Minneapolis, Minnesota; Gabriela...
The changes in each year influenza vaccine antigenic components as well administration patterns may pose new risks of adverse events following immunization (AEs). To evaluate the safety vaccines annually administered to people ≥ 6 months, we conducted weekly post licensure surveillance for seven pre-specified receipt during 2013-2014 and 2014-2015 seasons Vaccine Safety Datalink (VSD).
Cladribine tablets are contraindicated during pregnancy; therefore, safety data on pregnancies exposed to this treatment limited. CLEAR collects and describes pregnancy outcomes in understudied population. To describe the main features of study design, including sources methodological approach, provide a status update. is non-interventional, multi-database, comparative cohort study. Four cohorts included: women with multiple sclerosis (MS) cladribine (maternal exposed); MS unexposed any...
A obesidade é uma doença crônica com etiologia multifatorial, vez que sua origem pode ser decorrente de fatores genéticos, ambientais, psicossociais e estilos vida. prevalência a importância das comorbidades associadas à fazem ela seja considerada mais alarmantes doenças nutricionais do mundo ocidental, tendo condição associada ao sofrimento, depressão comportamento esquiva social, os quais impactam negativamente vida dos indivíduos. O Sistema Único Saúde (SUS) possui um papel fundamental...
To evaluate the risk of spontaneous abortion after quadrivalent human papillomavirus (4vHPV) vaccination before and during pregnancy across seven integrated health systems within Vaccine Safety Datalink.Within a retrospective observational cohort, we compared risks for 4vHPV in three exposure windows: distal (16-22 weeks last menstrual period [LMP]), peripregnancy (within 6 LMP), (LMP through 19 gestation). Women 12-27 years age with between 2008 2014, continuous insurance enrollment 8...
Abstract Purpose To develop the infrastructure to conduct timely active surveillance for safety of influenza vaccines and other medical countermeasures in Sentinel System (formerly Mini‐Sentinel Pilot), a Food Drug Administration‐sponsored national system that typically relies on data are mature, settled, updated quarterly. Methods Three Data Partners provided their earliest available (“fresh”) cumulative claims vaccination health outcomes 3–4 times staggered basis during 2013–2014 season,...
BACKGROUND Policymakers may wish to align healthcare payment and quality of care while minimizing unintended consequences, particularly for safety net hospitals. OBJECTIVE To determine whether the 2008 Centers Medicare Medicaid Services Hospital-Acquired Conditions policy had a differential impact on targeted healthcare-associated infection rates in compared with non–safety DESIGN Interrupted time-series design. SETTING AND PARTICIPANTS Nonfederal acute hospitals that reported central...
BACKGROUND The 2008 Centers for Medicare & Medicaid Services hospital-acquired conditions policy limited additional payment deemed reasonably preventable. OBJECTIVE To examine whether this was associated with decreases in billing rates 2 targeted conditions, vascular catheter-associated infections (VCAI) and urinary tract (CAUTI). STUDY POPULATION Adult patients admitted to 569 acute care hospitals California, Massachusetts, or New York subject the policy. DESIGN We used an interrupted...
In the Post-Licensure Rapid Immunization Safety Monitoring Program, we examined risk of febrile seizures (FS) after trivalent inactivated influenza vaccine (TIV) and 13-valent pneumococcal conjugate (PCV13) during 2010-2011 season, adjusted for concomitant diphtheria tetanus acellular pertussis-containing vaccines (DTaP). Assuming children would receive both vaccines, whether same-day TIV PCV13 vaccination was associated with greater FS when compared separate-day vaccination.We used a...
Skeletal-related events (SREs) are common in men with bone metastases and have negative consequences for patients castration-resistant prostate cancer (CRPC), including pain, reduced quality of life, increased mortality. We estimated incidence rates first SREs a cohort CRPC the Surveillance, Epidemiology, End Results-Medicare database.We included aged ≥ 65 years diagnosis 2000-2011 if they had no prior malignancy (other than nonmelanoma skin cancer) surgical or medical castration subsequent...
Objective In 2008, the Centers for Medicare and Medicaid Services (CMS) stopped reimbursing hospital-acquired conditions (HACs) not present on admission (POA). We sought to understand why this policy did impact central line–associated bloodstream infection (CLABSI) catheter-associated urinary tract (CAUTI) trends. Design Retrospective cohort study. Setting Acute-care hospitals in United States. Participants Fee-for-service patients discharged January 1, 2007, through December 31, 2011....
Thymic involution is associated with age-related changes of the immune system. Utilizing our innovative technique transplantation a thymus as an isolated vascularized graft in MHC-inbred miniature swine, we have previously demonstrated that aged thymi are rejuvenated after into juvenile swine. Here studied role insulin-like growth factor (IGF) and forkhead-box protein-N1 (FOXN1) well bone marrow (BM) thymic rejuvenation involution. We examined by means histology flow cytometry. function was...
Abstract Purpose The self‐controlled risk interval design is commonly used to assess the association between an acute exposure and adverse event of interest, implicitly adjusting for fixed, non‐time‐varying covariates. Explicit adjustment needs be made time‐varying covariates, example, age in young children. It can performed via either a fixed or random adjustment. random‐adjustment approach provide valid point estimates but requires access individual‐level data unexposed baseline sample....