A5017787663- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Asymmetric Synthesis and Catalysis
- Carbohydrate Chemistry and Synthesis
- Synthesis and Biological Evaluation
- Chemical Reaction Mechanisms
- Essential Oils and Antimicrobial Activity
- Crystallography and molecular interactions
- Coordination Chemistry and Organometallics
- Synthetic Organic Chemistry Methods
- Trypanosoma species research and implications
- Asymmetric Hydrogenation and Catalysis
- Chemical Synthesis and Reactions
- Plant Toxicity and Pharmacological Properties
- Natural product bioactivities and synthesis
- Pharmacological Effects of Natural Compounds
- Fungal Plant Pathogen Control
- Toxin Mechanisms and Immunotoxins
- Synthesis and biological activity
- Natural Antidiabetic Agents Studies
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Organophosphorus compounds synthesis
- Heavy Metals in Plants
- Organometallic Complex Synthesis and Catalysis
- Research on Leishmaniasis Studies
Instituto Politécnico Nacional
2010-2024
Tecnológico Nacional de México
2022
Universidad Autónoma del Estado de Morelos
2011
Center for Research and Advanced Studies of the National Polytechnic Institute
2006
The Burkholderia cepacia complex (Bcc) comprises a group of 24 species, many which are opportunistic pathogens immunocompromised patients and also widely distributed in agricultural soils. Several Bcc strains synthesize strain-specific antagonistic compounds. In this study, the broad killing activity B. cenocepacia TAtl-371, strain isolated from tomato rhizosphere, was characterized. This exhibits remarkable antagonism against bacteria, yeast fungi including other strains,...
A series of 2-benzylsulfanyl benzothiazole (BTA) derivatives were synthesized and fully characterized in vitro tested against two strains T. cruzi (NINOA INC-5), exhibiting good activities at low concentrations.
Abstract Uncatalyzed one‐pot, three‐component reactions of aldehydes, chiral α‐methylamines, and dimethyl phosphite under solvent‐free conditions were used for the diastereoselective synthesis α‐amino phosphonates. The proceeded with extremely high efficiency mild gave good yields diastereoselectivities (70:30 to 93:7 dr ). This approach could be useful large‐scale several
The new macrocycle 9 (>70% yield from hydroxythiol 10) was treated with several nucleophilic reagents (RMgX, RLi, and LiAlH4) affording carbinols 12a−j (80−96% yield, >99:1 dr). Oxidative hydrolysis of 12a,c,e, followed by LiAlH4 reduction the resulting mixture, gave 16a,c,e in >95% ee,16c being a key precursor for preparation fungicide 17. absolute configuration 12j (Nu = H) established single-crystal X-ray diffraction analyses chemical correlation.
The genus Crotalaria comprises about 600 species that are distributed throughout the tropics and subtropical regions of world; they antagonistic to nematodes in sustainable crop production systems, have also shown antimicrobial capacity. Chipilín (C. longirostrata), which belongs this genus, is a wild plant grows state Chiapas (Mexico) traditionally used as food. Its leaves medicinal properties hypnotics narcotics; however, has received little research attention date. In experimental part...
Chalcones are organic structures that occur naturally in flavonoids and isoflavonoids from diverse vegetables fruits. Their properties have promising applications medicinal chemistry as antiparasitic agents against malaria, leishmaniasis, Chagas disease. Parasitic diseases, a global health challenge, affect thousands of people around the world. The lack access to affordable treatments causes many deaths, especially developing countries. disease, neglected infection whose etiological agent is...
The Weinreb amides 2a,b were prepared from the α,α-dimethoxyacetic acids 1c,d. A number of representative nucleophilic additions (RMgX and RLi) on 2 afforded α-ketoacetals 3a–j in 70–99% yield. These compounds represent a versatile arrangement functional groups significant synthetic value, as demonstrated synthesis (±)-salbutamol.
Extracts of Hibiscus sabdariffa L. (commonly called Rosselle or "Jamaica flower" in Mexico) have been shown to antibiotic and antivirulence properties several bacteria. Here, an organic extract H. is inhibit motility Salmonella enterica serovars Typhi Typhimurium. The compound responsible for this effect was purified found be the hibiscus acid. When tested, also inhibited reduced secretion both flagellin type III effectors. Purified acid not toxic tissue-cultured eukaryotic cells, it able...
Infections caused by micro-organisms of the genus Candida are becoming a growing health problem worldwide. These fungi opportunistic commensals that can produce infections-clinically known as candidiasis-in immunocompromised individuals. The indiscriminate use different anti-fungal treatments has triggered resistance species to currently used therapies. In this sense, propolis been shown have potent antimicrobial properties and thus be an approach for inhibition species. Therefore, work aims...
A phytochemical and antibacterial study of Trixisangustifolia, a species endemic to Mexico, was performed allowing the isolation six flavones. The minimal inhibitory concentration (MIC) hexanic extract, against Mycobacterium tuberculosis H37Rv 25 μg/mL. extract caused significant inhibition intracellular mycobacterial growth at 12.5 biodirected assay hexane enabled detection an active fraction (AF) M. (MIC = μg/mL), major flavone 1 (pebrellin) with no antimycobacterial activity > 200 μg/mL)....
The aim of the present study was to evaluate hypoglycemic potential Trixis angustifolia in alloxan-induced diabetic mice. An intragastric adminis-tration aqueous extract (50, 100 and 200 mg/kg) prepared from aerial parts T. evaluated. treatment with at mg/kg produced a significant lowered (30.5%) blood glucose levels mice after 15 days daily oral administration. In addition, induced decrease serum total cholesterol, low density lipoprotein whereas increased high-density level. Additionally,...
Plant cuticles have attracted attention because they can be used to produce hydrophobic films as models for novel biopolymers. Usually, are obtained from agroresidual waste. To find new renewable natural sources design green and commercially available bioplastics, fruits of S. aculeatissimum myriacanthum were analyzed. These not human or animal consumption, mainly the fruit is composed seeds. Fruit peels object enzymatic chemical methods get thick cutins in good yields (approximately 77% dry...
“Gordolobo”(Gnaphalium sp) is a Mexican medicinal plant understudied for the treatment of diabetes; therefore, aim was to evaluate chloroformic extract G sp. (CEG) in alloxan-induced diabetic rats. Sesquiterpene lactones, polyphenolic compounds, triterpenes and steroids, apigenin, lauric myristic acid were identified CEG by phytochemical, HPLC GC-MS analysis; antioxidant capacity evaluated FRAP, DPPH ABTS, inhibited formation free radicals. There no lethality or toxicity at doses 2000 mg/kg....
Pseudo-C2-symmetric dodecaheterocyclic structures, which possess two acyl/aroyl groups disposed on either a cis- or trans-relative configuration, were prepared from the naturally occurring (-)-(1R)-myrtenal. Addition of Grignard reagents (RMgX) to diastereoisomeric mixture these compounds unexpectedly showed that nucleophilic additions prochiral carbonyl centers gave same stereochemical result in both cis/trans diastereoisomers, making unnecessary separation this mixture. Noticeably,...